THE NON-COMPETITIVE INHIBITION OF BRAIN HEXOKINASE BY GLUCOSE-6-PHOSPHATE AND RELATED COMPOUNDS
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FDG is a radioactive glucose 2-DG analog that does not enter the glycolytic or Krebs cycle metabolic pathways in the brain.
“18 F-fluoro-2-deoxyglucose (2-DG) (also known as FDG) is a radioactive glucose 2-DG analog that does not enter the glycolytic or Krebs cycle metabolic pathways in the brain (124, 397, 504, 552).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [124]
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Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076 · see citing works
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H)
Boslett, J., Hemann, C., Zhao, Y. J., Lee, H.-C., & Zweier, J. L. (2017) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.239459 · Cited by 69 · see citing works
- Authors
- Crane, R. K., & Sols, A.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Crane, Robert K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1954-10
- Volume
- 210
- Issue
- 2
- Pages
- 597-606
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W13653301
- Cited by
- 276
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 4 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Biblioteca Digital (Real Academia Nacional de Medicina) (submittedVersion, public-domain)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Keywords
- hexokinase, non-competitive inhibition, glucose-6-phosphate, brain, enzyme inhibition, glucose metabolism
- MeSH terms
- Brain, Hexokinase, Hexosephosphates, Humans, Neurochemistry, Phosphotransferases, Glucose-6-Phosphate
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