Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H)

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704 · see citing works

Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study

Hertog, M. G. L., Feskens, E. J. M., Kromhout, D., Hertog, M. G. L., Hollman, P. C. H., Hertog, M. G. L., & Katan, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92876-u · Cited by 4,336 · see citing works

Flavonoids: a review of probable mechanisms of action and potential applications

Nijveldt, R. J., van Nood, E., van Hoorn, D. E. C., Boelens, P. G., van Norren, K., & van Leeuwen, P. A. M. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.4.418 · Cited by 3,074 · see citing works

Endothelial Function and Dysfunction: Testing and Clinical Relevance

Deanfield, J. E., Halcox, J. P., & Rabelink, T. J. (2007) · Circulation · doi:10.1161/circulationaha.106.652859 · Cited by 2,710 · see citing works

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

Hausenloy, D. J., & Yellon, D. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62874 · Cited by 2,357 · see citing works

The Original Michaelis Constant: Translation of the 1913 Michaelis-Menten Paper

Johnson, K., & Goody, R. (2011) · Biochemistry · doi:10.1021/bi201284u · Cited by 1,377 · see citing works

Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies

Williamson, G., & Manach, C. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.243s · Cited by 1,340 · see citing works

Dietary Flavonoids, Antioxidant Vitamins, and Incidence of Stroke: The Zutphen Study

Keli, S., Hertog, M. G., Feskens, E., & Kromhout, D. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440060059007 · Cited by 914 · see citing works

Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome.

Hadi, H. A. R., Carr, C. S., & Suwaidi, J. M. S. A. (2005) · PubMed Central · Cited by 807 · see citing works

Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study

Keli, S. O. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.156.6.637 · Cited by 781 · see citing works

The role of oxidants and free radicals in reperfusion injury

Zweier, J. L., & Talukder, M. F. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.02.025 · Cited by 739 · see citing works

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

Zweier, J. L., Kuppusamy, P., & Lutty, G. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.4046 · Cited by 601 · see citing works

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

Chen, C.-A., Wang, T.-Y., Varadharaj, S., Reyes, L. A., Hemann, C., Talukder, M. A. H., Chen, Y.-R., Druhan, L. J., & Zweier, J. L. (2010) · Nature · doi:10.1038/nature09599 · Cited by 594 · see citing works

Polyphenols and cardiovascular disease: effects on endothelial and platelet function

Vita, J. A. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.292s · Cited by 495 · see citing works

Paradoxical Influence of Calcium Ions on the Permeability of the Cell Membranes of the Isolated Rat Heart

Zimmerman, A. N. E., & Hülsmann, W. C. (1966) · Nature · doi:10.1038/211646a0 · Cited by 479 · see citing works

Flavonoid-Rich Dark Chocolate Improves Endothelial Function and Increases Plasma Epicatechin Concentrations in Healthy Adults

Engler, M. B., Engler, M. M., Chen, C. Y., Malloy, M. J., Browne, A., Chiu, E. Y., Kwak, H., Milbury, P. E., Paul, S. M., Blumberg, J. B., et al. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719361 · Cited by 465 · see citing works

The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake

Bailey, S., & Ayling, J. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902072106 · Cited by 421 · see citing works

Measurement and characterization of postischemic free radical generation in the isolated perfused heart

Zweier, J. L., Kuppusamy, P., Williams, R., Rayburn, B. K., Smith, D., Weisfeldt, M. L., & Flaherty, J. T. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47240-2 · Cited by 383 · see citing works

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38

Escande, C., Nin, V., Price, N. L., Capellini, V., Gomes, A. P., Barbosa, M. T., O’Neil, L., White, T. A., Sinclair, D. A., & Chini, E. N. (2013) · Diabetes · doi:10.2337/db12-1139 · Cited by 332 · see citing works

Properties of 3-Deoxyanthocyanins from Sorghum

Awika, J. M., Rooney, L. W., & Waniska, R. D. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049653f · Cited by 327 · see citing works

Antihypertensive effects of the flavonoid quercetin

Pérez‐Vizcaíno, F., Duarte, J., Jiménez, R., Santos‐Buelga, C., & Osuna, A. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70008-8 · Cited by 317 · see citing works

Occurrence of oxidative stress during reperfusion of the human heart.

Ferrari, R., Alfieri, O., Curello, S., Ceconi, C., Cargnoni, A., Marzollo, P., Pardini, A., Caradonna, E., & Visioli, O. (1990) · Circulation · doi:10.1161/01.cir.81.1.201 · Cited by 295 · see citing works

THE NON-COMPETITIVE INHIBITION OF BRAIN HEXOKINASE BY GLUCOSE-6-PHOSPHATE AND RELATED COMPOUNDS

Crane, R. K., & Sols, A. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65385-2 · Cited by 276 · see citing works

Chronic Dietary Intake of Plant-Derived Anthocyanins Protects the Rat Heart against Ischemia-Reperfusion Injury3

Toufektsian, M.-C., de Lorgeril, M., Nagy, N., Salen, P., Donati, M. B., Giordano, L., Mock, H., Peterek, S., Matros, A., Petroni, K., et al. (2008) · Journal of Nutrition · doi:10.1093/jn/138.4.747 · Cited by 251 · see citing works

Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) as Messengers for Calcium Mobilization

Lee, H. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.349464 · Cited by 196 · see citing works

Myocardial ischemia results in tetrahydrobiopterin (BH ₄ ) oxidation with impaired endothelial function ameliorated by BH ₄

Dumitrescu, C., Biondi, R., Xia, Y., Cardounel, A. J., Druhan, L. J., Ambrosio, G., & Zweier, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702986104 · Cited by 192 · see citing works

Epigallocatechin, a Green Tea Polyphenol, Attenuates Myocardial Ischemia Reperfusion Injury in Rats

Aneja, R. K., Hake, P. W., Burroughs, T. J., Denenberg, A. G., Wong, H. R., & Zingarelli, B. (2004) · Molecular Medicine · doi:10.2119/2004-00032.aneja · Cited by 182 · see citing works

Resveratrol protects myocardial ischemia–reperfusion injury through both NO-dependent and NO-independent mechanisms

Hung, L., Su, M., & Chen, J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.12.016 · Cited by 178 · see citing works

Dietary Flavones and Flavonoles Are Inhibitors of Poly(ADP-ribose)polymerase-1 in Pulmonary Epithelial Cells ,

Geraets, L., Moonen, H. J. J., Brauers, K. J. J., Wouters, E. F. �., Bast, A., & Hageman, G. J. (2007) · Journal of Nutrition · doi:10.1093/jn/137.10.2190 · Cited by 175 · see citing works

Systemic and Vascular Oxidation Limits the Efficacy of Oral Tetrahydrobiopterin Treatment in Patients With Coronary Artery Disease

Cunnington, C., Van Assche, T., Shirodaria, C., Kylintireas, I., Lindsay, A. C., Lee, J. M., Antoniades, C., Margaritis, M., Lee, R., Cerrato, R., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.038919 · Cited by 166 · see citing works

Myocardial Postischemic Injury Is Reduced by PolyADPribose Polymerase-1 Gene Disruption

Pieper, A. A., Walles, T., Wei, G., Clements, E. E., Verma, A. M., Snyder, S. H., & Zweier, J. L. (2000) · Molecular Medicine · doi:10.1007/bf03401936 · Cited by 156 · see citing works

High-Performance Liquid Chromatography Analysis of Oxidized and Reduced Pyridine Dinucleotides in Specific Brain Regions

Klaidman, L. K., Leung, A. C., & Adams, J. D., Jr. (1995) · Analytical Biochemistry · doi:10.1006/abio.1995.1356 · Cited by 147 · see citing works

Discovery, synthesis, and biological evaluation of thiazoloquin(az)olin(on)es as potent CD38 inhibitors

Haffner, C. D., Becherer, J. D., Boros, E. E., Cadilla, R., Carpenter, T., Cowan, D., Deaton, D. N., Guo, Y., Harrington, W., Henke, B. R., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm502009h · Cited by 137 · see citing works

Characterization of the Mechanism and Magnitude of Cytoglobin-mediated Nitrite Reduction and Nitric Oxide Generation under Anaerobic Conditions

Li, H., Hemann, C., Abdelghany, T. M., El-Mahdy, M. A., & Zweier, J. L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.342378 · Cited by 132 · see citing works

Hypoxia and Reoxygenation Induce Endothelial Nitric Oxide Synthase Uncoupling in Endothelial Cells through Tetrahydrobiopterin Depletion and S-Glutathionylation

De Pascali, F., Hemann, C., Samons, K., Chen, C.-A., & Zweier, J. L. (2014) · Biochemistry · doi:10.1021/bi500076r · Cited by 131 · see citing works

Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes

Chang, W., Shao, Z., Yin, J., Mehendale, S. R., Wang, C., Qin, Y., Li, J., Chen, W., Chien, C., Becker, L. B., et al. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.03.037 · Cited by 109 · see citing works

Multiple NADPH-producing pathways control glutathione (GSH) content in retina

Winkler, B. S., Desantis, N. M., & Solomon, F. (1986) · Experimental Eye Research · doi:10.1016/s0014-4835(86)80013-6 · Cited by 106 · see citing works

Flavonoids as inhibitors of human CD38

Kellenberger, E., Kuhn, I., Schuber, F. J., & Muller‐Steffner, H. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.05.022 · Cited by 104 · see citing works

Role of NADPH Oxidase in Endothelial Ischemia/Reperfusion Injury in Humans

Loukogeorgakis, S., van den Berg, J. M., Sofat, R., Nitsch, D., Charakida, M., Haiyee, B., de Groot, E., MacAllister, R. J., Kuijpers, T. W., & Deanfield, J. E. (2010) · Circulation · doi:10.1161/circulationaha.108.814731 · Cited by 104 · see citing works

Tea, flavonoids, and cardiovascular health: endothelial protection

Grassi, D., Desideri, G., Giosia, P. D., Feo, M. D., Fellini, E., Cheli, P., Ferri, L., & Ferri, C. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.058313 · Cited by 101 · see citing works

Short- and long-term effects of (−)-epicatechin on myocardial ischemia-reperfusion injury

Yamazaki, K. G., Romero‐Perez, D., Barraza-Hidalgo, M., Cruz, M., Rivas, M., Cortez‐Gomez, B., Ceballos, G. M., & Villarreal, F. J. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00413.2008 · Cited by 98 · see citing works

Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion‐induced injury

Scarabelli, T. M., Mariotto, S., Abdel‐Azeim, S., Shoji, K., Darra, E., Stephanou, A., Chen-Scarabelli, C. A., Maréchal, J., Knight, R. A., Ciampa, A. R., et al. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.12.037 · Cited by 96 · see citing works

EFFECTS OF TEA AND TEA FLAVONOIDS ON ENDOTHELIAL FUNCTION AND BLOOD PRESSURE: A BRIEF REVIEW

Hodgson, J. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04450.x · Cited by 84 · see citing works

Cyanidin-3- O -β-glucopyranoside Protects Myocardium and Erythrocytes from Oxygen Radical-mediated Damages

Amorini, A. M., Lazzarino, G., Galvano, F., Fazzina, G., Tavazzi, B., & Galvano, G. (2003) · Free Radical Research · doi:10.1080/1071576021000055253 · Cited by 75 · see citing works

Poly(ADP-ribose) polymerase activation in the reperfused myocardium

Szabo, G. B. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.09.029 · Cited by 75 · see citing works

Superoxide Induces Endothelial Nitric-oxide Synthase Protein Thiyl Radical Formation, a Novel Mechanism Regulating eNOS Function and Coupling

Chen, C., Lin, C.-H., Druhan, L. J., Wang, T.-Y., Chen, Y.-R., & Zweier, J. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.240127 · Cited by 74 · see citing works

Inhibition of glioma progression by a newly discovered CD38 inhibitor

Blacher, E., Baruch, B. B., Levy, A., Geva, N., Green, K. D., Garneau‐Tsodikova, S., Fridman, M., & Stein, R. (2014) · International Journal of Cancer · doi:10.1002/ijc.29095 · Cited by 69 · see citing works

Conformational preferences of 1,4,7-trithiacyclononane: a molecular mechanics and density functional theory study

Jagannadh, B., Reddy, S. S., & Thangavelu, R. P. (2004) · Journal of Molecular Modeling · doi:10.1007/s00894-003-0166-5 · Cited by 69 · see citing works

Natural and glucosyl flavonoids inhibit poly(ADP-ribose) polymerase activity and induce synthetic lethality in BRCA mutant cells

Maëda, J., Roybal, E. J., Brents, C. A., Uesaka, M., Aizawa, Y., & Kato, T. A. (2013) · Oncology Reports · doi:10.3892/or.2013.2902 · Cited by 65 · see citing works

Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart

Reyes, L. A., Boslett, J. J., Varadharaj, S., Pascali, F. D., Hemann, C. F., Druhan, L. J., Ambrosio, G., El‐Mahdy, M. A., & Zweier, J. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505556112 · Cited by 65 · see citing works

[29] Large-scale production of human CD38 in yeast by fermentation

Munshi, C. B., Fryxell, K., Lee, H. C., & Branton, W. D. (1997) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(97)80123-1 · Cited by 64 · see citing works

Dietary polyphenol quercetin protects rat hearts during reperfusion: enhanced antioxidant capacity with chronic treatment.

İkizler, M., Erkasap, N., Dernek, S., Kural, T., & Kaygısız, Z. (2007) · PubMed · Cited by 63 · see citing works

Protective effects of EGCg or GCg, a green tea catechin epimer, against postischemic myocardial dysfunction in guinea-pig hearts

Hirai, M., Hotta, Y., Ishikawa, N., Wakida, Y., Fukuzawa, Y., Isobe, F., Nakano, A., Chiba, T., & Kawamura, N. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.11.032 · Cited by 61 · see citing works

2′-Phospho-Cyclic ADP-ribose, a Calcium-mobilizing Agent Derived from NADP

Vu, C. Q., Lu, P., Chen, C., & Jacobson, M. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.4747 · Cited by 58 · see citing works

Water content and its intracellular distribution in intact and saline perfused rat hearts revisited

Aliev, M. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00474-6 · Cited by 55 · see citing works

Discovery of 4-amino-8-quinoline carboxamides as novel, submicromolar inhibitors of NAD-hydrolyzing enzyme CD38

Becherer, J. D., Boros, E. E., Carpenter, T. Y., Cowan, D. J., Deaton, D. N., Haffner, C. D., Jeune, M. R., Kaldor, I. W., Poole, J. C., Preugschat, F., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00992 · Cited by 55 · see citing works

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation

Gul, R., Park, D., Shawl, A. I., Im, S.-Y., Nam, T., Lee, S. H., Ko, J.-K., Jang, K. Y., Kim, D., & Kim, U. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149125 · Cited by 49 · see citing works

Myocardial Ischemic Preconditioning in Rodents Is Dependent on Poly (ADP-Ribose) Synthetase

Liaudet, L., Yang, Z., Affar, E. B., & Szabó, C. (2001) · Molecular Medicine · doi:10.1007/bf03402187 · Cited by 48 · see citing works

Genetic Selection inEscherichia colifor Active Human Immunodeficiency Virus Reverse Transcriptase Mutants

Kim, B. (1997) · Methods · doi:10.1006/meth.1997.0485 · Cited by 37 · see citing works

Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability

Gao, L., Pung, Y. F., Zhang, J., Chen, P., Wang, T., Li, M., Meza, M. A., Toro, L., & Cai, H. “. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00007.2009 · Cited by 33 · see citing works

Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase

Wang, S., Zhu, W., Wang, X., Li, J., Zhang, K., Zhang, L., Zhao, Y. J., Lee, H., & Zhang, L. (2014) · Molecules · doi:10.3390/molecules191015754 · Cited by 32 · see citing works

Protective Pleiotropic Effect of Flavonoids on NAD+Levels in Endothelial Cells Exposed to High Glucose

Boesten, D. M. P. H. J., von Ungern‐Sternberg, S. N. I., den Hartog, G. J. M., & Bast, A. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/894597 · Cited by 26 · see citing works

Effects of different fractions of a red wine non-alcoholic extract on ischemia-reperfusion injury

Fantinelli, J. C., Schinella, G. R., Cingolani, H. E., & Mosca, S. M. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.10.044 · Cited by 26 · see citing works

CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template

Moreau, C., Liu, Q., Graeff, R. M., Wagner, G. K., THOMAS, M. P., Swarbrick, J. M., Shuto, S., Lee, H. C., Hao, Q., & Potter, B. V. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066247 · Cited by 25 · see citing works

Endothelial dysfunction does not require loss of endothelial nitric oxide synthase

Giraldez, R. R., Panda, A., & Zweier, J. L. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.6.h2020 · Cited by 19 · see citing works

[Protective effects of the flavonoids osajin and pomiferin on heart ischemia-reperfusion].

Nečas, J., Bartošíková, L., Florian, T., Klusáková, J., Suchý, V., Naggar, E. M. B. E., Janoštíková, E., Bartošík, T., & Lisková, M. (2006) · PubMed · Cited by 10 · see citing works

NAD+ metabolism and its roles in cellular processes during ageing

Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617 · see citing works

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Rajman, L., Chwalek, K., & Sinclair, D. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.011 · Cited by 865 · see citing works

Nitric oxide signalling in cardiovascular health and disease

Farah, C., Michel, L. Y. M., & Balligand, J.-L. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.224 · Cited by 779 · see citing works

NAD+ homeostasis in health and disease

Katsyuba, E., Romani, M., Hofer, D., & Auwerx, J. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0161-5 · Cited by 627 · see citing works

Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases

Kane, A. E., & Sinclair, D. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312498 · Cited by 490 · see citing works

Role of NAD+ in regulating cellular and metabolic signaling pathways

Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K. A., Haris, M., Reddy, R. D., Patay, Z. J., Baur, J. A., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101195 · Cited by 394 · see citing works

The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases

Hogan, K. A., Chini, C. C. S., & Chini, E. N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01187 · Cited by 337 · see citing works

The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging

Chini, E. N., Chini, C. C. S., Espindola Netto, J. M., de Oliveira, G. C., & van Schooten, W. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.02.001 · Cited by 227 · see citing works

Modulating NAD+ metabolism, from bench to bedside

Katsyuba, E., & Auwerx, J. H. (2017) · The EMBO Journal · doi:10.15252/embj.201797135 · Cited by 224 · see citing works

Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism

Hong, W., Mo, F., Zhang, Z., Huang, M., & Wei, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00246 · Cited by 179 · see citing works

Effects of Anthocyanins on Vascular Health

Mozos, I. M., Flangea, C., Vlad, D. C., Gug, C., Mozos, C., Stoian, D. L., Luca, C. T., Horbańczuk, J. O., Horbańczuk, O. K., & Atanasov, A. G. (2021) · Biomolecules · doi:10.3390/biom11060811 · Cited by 110 · see citing works

Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe?

Koju, N., Qin, Z., & Sheng, R. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00838-7 · Cited by 95 · see citing works

Chronic cigarette smoke exposure triggers a vicious cycle of leukocyte and endothelial-mediated oxidant stress that results in vascular dysfunction

Elmahdy, M., Abdelghany, T. M., Hemann, C. F., Ewees, M. G., Mahgoup, E. M., Eid, M. S., Shalaan, M. T., Alzarie, Y. A., & Zweier, J. L. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00657.2019 · Cited by 67 · see citing works

Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia-reoxygenation triggering NAD(P)H depletion

Boslett, J., Hemann, C., Christofi, F. L., & Zweier, J. L. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2017 · Cited by 65 · see citing works

The balance between NAD+ biosynthesis and consumption in ageing

Strømland, Ø., Diab, J., Ferrario, E., Sverkeli, L. J., & Ziegler, M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111569 · Cited by 63 · see citing works

Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan

Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2023) · Nutrients · doi:10.3390/nu15020445 · Cited by 60 · see citing works

Research Progress on Absorption, Metabolism, and Biological Activities of Anthocyanins in Berries: A Review

Xue, H., Sang, Y., Gao, Y., Zeng, Y., Liao, J., & Tan, J. (2022) · Antioxidants · doi:10.3390/antiox12010003 · Cited by 58 · see citing works

Inhibition of CD38 enzymatic activity enhances CAR-T cell immune-therapeutic efficacy by repressing glycolytic metabolism

Huang, Y., Shao, M., Teng, X., Si, X., Wu, L., Jiang, P., Liu, L., Cai, B., Wang, X., Han, Y., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101400 · Cited by 58 · see citing works

Flavonoids in myocardial ischemia-reperfusion injury: Therapeutic effects and mechanisms

Jia, J.-Y., Zang, E., Lv, L., Li, Q., Zhang, C., Xia, Y., Zhang, L. J., Dang, L.-S., & Li, M. (2020) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2020.09.002 · Cited by 50 · see citing works

Inhibition of CD38 with the Thiazoloquin(az)olin(on)e 78c Protects the Heart against Postischemic Injury

Boslett, J., Reddy, N., Alzarie, Y. A., & Zweier, J. L. (2019) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.254557 · Cited by 43 · see citing works

Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides

Boslett, J. J., Helal, M., Chini, E. N., & Zweier, J. L. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.02.015 · Cited by 39 · see citing works

Recent development of carrier materials in anthocyanins encapsulation applications: A comprehensive literature review

Fu, Z., Ju, H., Xu, G.-S., Wu, Y., Xiao, C., & Li, H. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.138104 · Cited by 34 · see citing works

CD38: A Potential Therapeutic Target in Cardiovascular Disease

Zuo, W., Liu, N., Zeng, Y., Liu, Y., Li, B., Wu, K., Xiao, Y., & Liu, Q. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07007-8 · Cited by 34 · see citing works

Targeting CD38 in Neoplasms and Non-Cancer Diseases

Szlasa, W., Czarny, J., Sauer, N. J., Rakoczy, K., Szymańska, N., Stecko, J., Kołodziej, M., Kaźmierczak, M., & Barg, E. (2022) · Cancers · doi:10.3390/cancers14174169 · Cited by 34 · see citing works

NAD+ Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death

Xu, W., Li, L., & Zhang, L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00901 · Cited by 33 · see citing works

Implications of NAD + boosters in translational medicine

Kang, B. E., Choi, J., Stein, S., & Ryu, D. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13334 · Cited by 32 · see citing works

NAD+ and Vascular Dysfunction: From Mechanisms to Therapeutic Opportunities

Abdellatif, M., Bugger, H., Kroemer, G., & Sedej, S. (2022) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2022.11.2.111 · Cited by 26 · see citing works

Sirtuins, a key regulator of ageing and age-related neurodegenerative diseases

Bhatt, V., & Tiwari, A. K. (2022) · International Journal of Neuroscience · doi:10.1080/00207454.2022.2057849 · Cited by 26 · see citing works

Jobelyn® ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-κB signaling pathway

Umukoro, S., Oghwere, E. E., Ben‐Azu, B., Owoeye, O., Ajayi, A. M., Omorogbe, O., & Okubena, O. (2018) · Pathophysiology · doi:10.1016/j.pathophys.2018.10.002 · Cited by 22 · see citing works

Orally Bioavailable Enzymatic Inhibitor of CD38, MK-0159, Protects against Ischemia/Reperfusion Injury in the Murine Heart

Lagu, B. R., Wu, X., Kulkarni, S. S., Paul, R., Becherer, J. D., Olson, L., Ravani, S., Chatzianastasiou, A., Papapetropoulos, A., & Andrzejewski, S. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00688 · Cited by 22 · see citing works

The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research

Kitada, M., Araki, S., & Koya, D. (2023) · Cells · doi:10.3390/cells12040595 · Cited by 21 · see citing works

Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective

Fan, Y., Zhao, H., Lu, L., & Wu, W. (2025) · Nutrients · doi:10.3390/nu17111855 · Cited by 19 · see citing works

Effects of Apocynin, a NADPH Oxidase Inhibitor, in the Protection of the Heart from Ischemia/Reperfusion Injury

Mohammad, A., Babiker, F. A., & Al‐Bader, M. (2023) · Pharmaceuticals · doi:10.3390/ph16040492 · Cited by 12 · see citing works

17β-Estradiol Promotes Apoptosis in Airway Smooth Muscle Cells Through CD38/SIRT1/p53 Pathway

Liu, Y., Guo, Y., Huang, W., Deng, K., Qian, Y., & Xin, H. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00770 · Cited by 12 · see citing works

Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights

Jain, A., Casanova, D., Padilla, A. V., Paniagua-Bojorges, A., Kotla, S., Ko, K. A., Samanthapudi, V. S. K., Chau, K. M., Nguyen, M. T., Wen, J. J., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1212174 · Cited by 11 · see citing works

Promising drug discovery strategies for sirtuin modulators: what lessons have we learnt?

Garg, G., Singh, A. K., Singh, S., & Rizvi, S. I. (2021) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2021.1915980 · Cited by 11 · see citing works

Characterizing CD38 Expression and Enzymatic Activity in the Brain of Spontaneously Hypertensive Stroke-Prone Rats

Hannawi, Y., Ewees, M. G., Moore, J. T., & Zweier, J. L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.881708 · Cited by 11 · see citing works

Adult patient diagnosed with NADSYN1 associated congenital NAD deficiency and analysis of NAD levels to be published in: European Journal of Medical Genetics

Erbs, E., Brasen, C. L., Lund, A. M., & Rasmussen, M. B. (2023) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2023.104698 · Cited by 11 · see citing works

Health properties of bioactive food compounds-loaded micro and nano-encapsulation systems: A review

Rashwan, A. K., Younis, H. A., Karim, N., Taha, E. M. A., Mozafari, M. R., Tawfeuk, H. Z., & Chen, W. (2022) · SVU-International Journal of Agricultural Sciences · doi:10.21608/svuijas.2022.134530.1208 · Cited by 10 · see citing works

Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications

Banerjee, P., Olmsted‐Davis, E. A., Deswal, A. M., Nguyen, M. T. H., Koutroumpakis, E., Palaskas, N., Lin, S. H., Kotla, S., Reyes‐Gibby, C. C., Yeung, S. J., et al. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.13 · Cited by 10 · see citing works

The Search for Drugs Derived from Natural Products for Toxoplasma gondii Infection Treatment in the Last 20 Years - A Systematic Review

Marques-Santos, F., Faria, R. X., & Amendoeira, M. R. R. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266299409240606062235 · Cited by 9 · see citing works

Rational Design and Identification of Small‐Molecule Allosteric Inhibitors of CD38

Yang, L., Li, T., Li, S., Wu, Y., Shi, X., Jin, H., Liu, Z., Zhao, Y. J., Zhang, L., Lee, H. C., et al. (2019) · ChemBioChem · doi:10.1002/cbic.201900169 · Cited by 9 · see citing works

Targeting CD38 to alleviate brain endothelial cell dysfunction and cognitive impairment in vascular dementia

Yu, M., Qi, Z., Zhang, J., Zhang, Z., Chen, J., Yan, T., & Chen, Z. (2025) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2025.05.013 · Cited by 7 · see citing works

NAD+ glycohydrolases-CD38 as a therapeutic target in aging: physiological roles, molecular mechanisms, and future opportunities in anti-aging research

Sun, J.-Y., Wang, Z., Xu, W., & Zhao, J. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117050 · Cited by 7 · see citing works

Metabolomics studies of allelopathy: a review

Barrales-Cureño, H. J., Herrera-Cabrera, B. E., Montoya, J. M., López-Valdez, L. G., Salgado‐Garciglia, R., Ocaño‐Higuera, V. M., Sánchez-Herrera, L. M., Lucho-Constantino, G. G., & Zaragoza-Martínez, F. (2022) · Revista Colombiana de Ciencias Químico Farmacéuticas · doi:10.15446/rcciquifa.v51n1.102693 · Cited by 7 · see citing works

The role of CD38 in ischemia reperfusion injury in cardiopulmonary bypass and thoracic transplantation: a narrative review

Gouchoe, D. A., Vijayakumar, A., Aly, A. H., Cui, E. Y., Essandoh, M. K., Gumina, R. J., Black, S. M., & Whitson, B. A. (2023) · Journal of Thoracic Disease · doi:10.21037/jtd-23-725 · Cited by 6 · see citing works

NAD+ enhancers as therapeutic agents in the cardiorenal axis

Marin-Blazquez, M., Rovira, J., Ramírez-Bajo, M. J., Perez, R. Z., & Rabadán-Ros, R. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01903-4 · Cited by 6 · see citing works

An Evidence-based Systematic Review of Pleiotropic Potential Health Benefits of Sorghum bicolor Supplement: A Polyphenol-rich Derivative of the Leaf Sheaths of Sorghum Plant

Adebesin, A., Omogbiya, A. I., Oluwole, O. G., Okubena, O., Asomadu, R. O., Afolabi, M., Makanjuola, S., Ajonuma, L. C., Dosunmu, A. O., Otitoloju, O., et al. (2024) · Journal of Natural Remedies · doi:10.18311/jnr/2024/33171 · Cited by 5 · see citing works

Potential dietary geroprotectors and their impact on key mechanisms of aging

Moskalev, A., & Veselova, O. M. (2025) · Biogerontology · doi:10.1007/s10522-025-10355-3 · Cited by 4 · see citing works

Aging and anti-aging strategies: A review of past and future therapeutics

Wei, Y., Xiong, B., Song, Z., Zhong, S., Zheng, N., Zhang, A., Chen, Y., & Sun, H. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118340 · Cited by 4 · see citing works

A dual approach to flavonoid toxicity assessment: Bridging computational and experimental paradigms

Das, M., Kityania, S., Nath, P., Nath, R., Herqash, R. N., Shahat, A. A., Nath, D., & Talukdar, A. D. (2025) · Computational Toxicology · doi:10.1016/j.comtox.2025.100355 · Cited by 3 · see citing works

Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting EffectsPreprint

Okubena, O., Adebesin, A., Omogbiya, A. I., Oluwole, O., Asomadu, R. O., Afolabi, M., Makanjuola, S., Ajonuma, L. C., Dosunmu, A. O., Otitoloju, O., et al. (2022) · Preprints.org · doi:10.20944/preprints202208.0011.v1 · Cited by 2 · see citing works

CD38 connects the heart and brain

Tao, Y., Duan, J., Huang, K., Wang, R., Feng, Q., Yang, C., Zhang, X., & Yang, L. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03597-9 · Cited by 2 · see citing works

NAD + in fatty liver disease: mechanistic insights and associated targets

Guo, Y.-X., Wang, Y., Wu, S., Wang, Y., & Liu, X. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-025-10106-7 · Cited by 3 · see citing works

Pharmacological Approaches for Modulating Sirtuins

Kane, A. E., & Sinclair, D. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813499-3.00006-x · Cited by 2 · see citing works

Nicotinamide Adenine Dinucleotide and Aging

Jiang, Z., Luo, L., Qin, Y., Huang, Y., & Yan, S. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_28 · Cited by 1 · see citing works

Flavonoid-mediated modulation of Tau protein: Implications for targeted therapeutics and clinical relevance in Tau-related disorders

Hedna, R., Relave, E. T., Robin, M., Kovacic, H., & Breuzard, G. (2025) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2025.100309 · Cited by 1 · see citing works

烟酰胺腺嘌呤二核苷酸（NAD+）合成代谢及其调控机体衰老研究进展

Li, Y., Tian, X., Luo, J., Bao, T., & Wu, X. (2024) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0004

Sirtuin signaling in hematologic malignancies

Denu, R. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822467-0.00012-7

The Role of NAD+ in Rejuvenating Human Body

Kiosk, B., & Biswas, S. (2020) · Biotechnology Kiosk · doi:10.37756/bk.20.2.12.1

Sorghum Phenolic Compounds: Revisiting the Therapeutic Aspects and Processing Opportunities

Santana, Á. L., Peterson, J., Siliveru, K., & Smolensky, D. (2024) · Reference series in phytochemistry · doi:10.1007/978-3-031-30037-0_14-1

Coenzyme II and Heart Disease

Koju, N., Zhou, M., & Sheng, R. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_37

Sorghum Phenolic Compounds: Revisiting the Therapeutic Aspects and Processing Opportunities

Santana, Á. L., Peterson, J., Siliveru, K., & Smolensky, D. (2025) · Reference series in phytochemistry · doi:10.1007/978-3-031-51158-5_14

Standardized Tamarindus indica and Colocasia esculenta leaves extracts alleviate obesity in high fat, high sucrose and letrozole-induced obese rats

Anis, S., Elsharkawy, E. R., Ishtiaq, S., Kamran, S. H., Sarfaraz, S. A., Azhar, I., Youssef, F. S., & Ashour, M. L. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.106824

Exploring the impact of anthocyanins in berries on cardiovascular health

Waheed, W., Ikhlaq, H., Latif, S., Tahir, A., Ashraf, S., & Sahni, O. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33935-6.00017-5

Large-Scale Plasma Proteomics and Genetic Integration Uncover Novel Biological Pathways in Male Pattern Baldness

Pan, L., Li, C., Moog, P., Knoedler, S. A., Kükrek, H., Dornseifer, U., Machens, H.-G., & Jiang, J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27042052

Repositioning of niacin in atherosclerotic cardiovascular disease

Li, W., Bai, Z., Li, C., Lu, S., Wang, Y., Huang, D., Zhang, H., Yuan, J., Zhen, X., & Liu, Y. (2026) · PharmaNutrition · doi:10.1016/j.phanu.2026.100506

Network pharmacology-guided investigation of the anti-angiogenic mechanisms of Spatholobus suberectus Dunn stem in rheumatoid arthritis

Qingsong, L. I., Yang, L. I. U., Zhengxin, Z. H. O. U., HUANG, Y., 邓龙文, & Yaohui, Y. E. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.122474

BindingDB Entry 50017291: Orally Bioavailable Enzymatic Inhibitor of CD38,

BindingDB (2023) · UC San Diego · doi:10.7270/q2gb2848

Abstract 20167: The CD38 Inhibitor Luteolinidin Ameliorates Ischemia/reperfusion Injury Through Preservation of NADP(H) and NAD(H)

Boslett, J. J., Pascali, F. D., Hemann, C. F., & Zweier, J. L. (2014) · Circulation

Luteolinidin, a naturally occurring flavonoid, decreases ischemia/reperfusion injury through inhibition of CD38 and preservation of NADPH and BH 4 (547.14)

Boslett, J. J., Pascali, F. D., Hemann, C. F., & Zweier, J. L. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.547.14

Inhibition of CD38 with the Thiazoloquin(az)olin(on)e 78c Protects the Heart against Postischemic Injury

Boslett, J., Reddy, N., Alzarie, Y. A., & Zweier, J. L. (2019) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.254557 · Cited by 43 · see citing works

Post‐ischemic Cardiac Protection by NADPH Supplementation or CD38 Inhibition is Dependent on Endothelial Nitric Oxide Synthase (eNOS)

Boslett, J. J., & Zweier, J. L. (2017) · The FASEB Journal · doi:10.1096/fasebj.31.1_supplement.846.4

Abstract 19525: Knockout of CD38 Preserves Endothelial Function in the Postischemic Heart through Reduced Nicotinamide Adenine Dinucleotide Phosphate Salvage

Boslett, J. J., Chini, E. N., & Zweier, J. L. (2014) · Circulation · doi:10.1161/circ.130.suppl_2.19525