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THE RELATIONSHIP OF EPINEPHRINE AND GLUCAGON TO LIVER PHOSPHORYLASE
Open accessAbstract
Evidence has been presented which showed that the enzymatic inactivation of liver phosphorylase was accompanied by t,he removal of phosphate from the enzyme (1, 2). It was reasoned that the conversion of dephosphophosphorylase (inactive LP)’ to the active enzyme should involve the addition of phosphate to the molecule. Therefore, the reactivation process was studied in liver slices with P32-orthophosphate to detect entrance of phosphate into the enzyme and also in liver extracts with purified dephospho-LP as substrate. It was found that P32-orthophosphate was rapidly incorporated into phosphorylase in liver slices and this incorporation was greatly increased under the influence of epinephrine and glucagon. Furthermore, a soluble liver enzyme2 capable of converting dephospho-LP to LP in the presence of ATP and magnesium ions was found and purified.
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Cited by
Hutson, N. J., Brumley, F. T., Assimacopoulos, F. D., Harper, S. C., & Exton, J. H. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33147-2 · Cited by 348
STUDIES ON THE MECHANISM OF ACTION OF THE ADRENOCORTICOTROPIC HORMONE
Haynes, R. C., & Berthet, L. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64914-2 · Cited by 332
Effect of glucagon on the metabolism of adipose tissue
Hagen, J. H. (1961) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64236-x · Cited by 212
Biochemical and Clinical Aspects of Glycogen Storage Diseases
Ellingwood, S. S., & Cheng, A. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0120 · Cited by 118
Some aspects of the glucagon problem
Berthet, J. (1959) · The American Journal of Medicine · doi:10.1016/0002-9343(59)90229-3 · Cited by 27
Metadata
- Authors
- Sutherland, E. W., & Wosilait, W. D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1956-01
- Volume
- 218
- Issue
- 1
- Pages
- 459-468
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W31601866
- Cited by
- 370
- References
- 0
- FWCI
- 10.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: THE RELATIONSHIP OF EPINEPHRINE AND GLUCAGON TO LIVER PHOSPHORYLASE. https://app.cochat.ai/papers/10.1016/s0021-9258(18)65909-5
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- Sutherland, E. W., & Wosilait, W. D. (1956). THE RELATIONSHIP OF EPINEPHRINE AND GLUCAGON TO LIVER PHOSPHORYLASE. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)65909-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
