The DOI matches its Crossref record.
Binding of single-chain prourokinase to the urokinase receptor of human U937 cells.
Open accessAbstract
The single-chain form of human urokinase plasminogen activator (uPA) is the major form of the enzyme found in cells, tissues, and extracellular fluids. The protein, called pro-uPA, has high (Kd = 0.5 nM) affinity for the specific uPA receptor of U937 human monocyte-like cells. Its conversion to two-chain uPA by plasmin does not appreciably change the binding parameters. In addition, conversion of pro-uPA to uPA occurs with receptor-bound pro-uPA and does not lead to dissociation from the membrane. These data show that secreted pro-uPA can find its way to the specific surface receptor without previous conversion to the two-chain form and that, once bound, can be activated by plasmin.
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Cited by
Cell-Associated Plasminogen Activation: Regulation and Physiological Functions
Saksela, O., & Rifkin, D. B. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.000521 · Cited by 818
Estreicher, A., Mühlhauser, J., Carpentier, J. L., Orci, L., & Vassalli, J. D. (1990) · The Journal of cell biology · doi:10.1083/jcb.111.2.783 · Cited by 469
Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator
Ellis, V, Scully, M. F., & Kakkar, V. V. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94159-1 · Cited by 332
Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes
Nykjar, A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2610 · Cited by 309
Behrendt, N., Rønne, E., Ploug, M., Petri, T., Løber, D., Nielsen, L. S., Schleuning, W. D., Blasi, F., Appella, E., & Danø, K. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39348-2 · Cited by 274
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Metadata
- Authors
- Cubellis, M. V., Nolli, M. L., Cassani, G., & Blasi, F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1986-12
- Volume
- 261
- Issue
- 34
- Pages
- 15819-15822
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1584486859
- Cited by
- 187
- References
- 0
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cubellis, M. V., Nolli, M. L., Cassani, G., & Blasi, F. (1986). Binding of single-chain prourokinase to the urokinase receptor of human U937 cells. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)66635-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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