The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator
Open accessAbstract
The binding of urokinase-type plasminogen activators (u-PA) to receptors on various cell types has been proposed to be an important feature of many cellular processes requiring extracellular proteolysis. We have investigated the effect of single-chain u-PA binding to the monocyte-like cell line U937 on plasminogen activation. A 16-fold acceleration of the activation of plasminogen was observed at optimal concentrations of single-chain u-PA. This potentiation was abolished by the addition of either 6-aminohexanoic acid or the amino-terminal fragment of u-PA, thus demonstrating the requirement for specific binding of both single-chain u-PA and plasminogen to the cells. The mechanism of the enhancement of plasmin generation appears to be due primarily to an increase in the rate of feedback activation of single-chain u-PA to the more active two-chain u-PA by cell-bound plasmin, initially generated by single-chain u-PA. This increased activity of the plasminogen activation system in the presence of U937 cells provides a mechanism whereby u-PAs may exert their influence in a variety of cell-associated proteolytic events.
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Cites
Plasminogen Activators, Tissue Degradation, and Cancer
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Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)
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On the Regulation and Control of Fibrinolysis: Edward Kowalski Memorial Lecture
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A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.
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Plasminogen activator in early embryogenesis: Enzyme production by trophoblast and parietal endoderm
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Appella, E., Robinson, E. A., Ullrich, S. J., Stoppelli, M. P., Corti, A., Cassani, G., & Blasi, F. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61211-6 · Cited by 475
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Plasminogen activation and regulation of pericellular proteolysis
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Cited by
Behrendt, N., Rønne, E., Ploug, M., Petri, T., Løber, D., Nielsen, L. S., Schleuning, W. D., Blasi, F., Appella, E., & Danø, K. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39348-2 · Cited by 274
Matrix metalloproteinases and cellular fibrinolytic activity
Lijnen, H. R. (2002) · Biochemistry (Moscow) · doi:10.1023/a:1013908332232 · Cited by 167
Metrangolo, V., Ploug, M., & Engelholm, L. H. (2021) · Cancers · doi:10.3390/cancers13215376 · Cited by 44
Metadata
- Authors
- Ellis, V, Scully, M. F., & Kakkar, V. V.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1989-02
- Volume
- 264
- Issue
- 4
- Pages
- 2185-2188
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1581591459
- Cited by
- 332
- References
- 15
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ellis, V, Scully, M. F., & Kakkar, V. V. (1989). Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)94159-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
