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Nucleotide sequence of the structural genes for an anion pump. The plasmid-encoded arsenical resistance operon.
Open accessAbstract
The structural genes for the arsenical pump of the conjugative R-factor R773 contained on a HindIII fragment of 4.3 kilobase pairs were cloned into bacteriophage M13. A series of ordered deletions was created using Bal31 digestion, and the nucleotide sequence of the operon determined. Three open reading frames for genes arsA, arsB, and arsC were found. The arsA gene encodes a hydrophilic protein of 63,169 Da with two potential adenylate-binding sites. The arsB gene encodes a potentially membrane protein of 45,577 Da. The arsC gene encodes a 15,811-Da hydrophilic protein. The arsA and arsC gene products correspond to cytosolic proteins previously identified from minicell experiments. Isolated ArsA protein was shown to bind to dye-agarose columns which act as affinity resins for nucleotide-binding proteins. A model is proposed in which these gene products form an anion translocating ATPase for extrusion of arsenite and arsenate from resistant cells.
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Cited by
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Classification and evolution of P-loop GTPases and related ATPases
Leipe, D. D., Wolf, Y. I., Koonin, E. V., & Aravind, L. (2002) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.5378 · Cited by 1,148
Arsenic in the environment: Biology and Chemistry
Bhattacharya, P., Welch, A. H., Stollenwerk, K. G., McLaughlin, M. J., Bundschuh, J., & Panaullah, G. (2007) · Science of The Total Environment · doi:10.1016/j.scitotenv.2007.02.037 · Cited by 625
Bacterial tellurite resistance
Taylor, D. E. (1999) · Trends in Microbiology · doi:10.1016/s0966-842x(99)01454-7 · Cited by 365
Resistance to arsenic compounds in microorganisms
Cervantes, C. (1994) · FEMS Microbiology Reviews · doi:10.1016/0168-6445(94)90069-8 · Cited by 331
Metadata
- Authors
- Chen, C. M., Misra, T. K., Silver, S., & Rosen, B. P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1986-11
- Volume
- 261
- Issue
- 32
- Pages
- 15030-15038
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1492501257
- Cited by
- 327
- References
- 0
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Nucleotide sequence of the structural genes for an anion pump. The plasmid-encoded arsenical resistance operon. https://app.cochat.ai/papers/10.1016/s0021-9258(18)66824-3
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- Chen, C. M., Misra, T. K., Silver, S., & Rosen, B. P. (1986). Nucleotide sequence of the structural genes for an anion pump. The plasmid-encoded arsenical resistance operon. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)66824-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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