The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Glucagon gene expression in vertebrate brain.
Open accessAbstract
An increasing number of regulatory peptide genes are known to be transcribed in neuroendocrine cells of the intestine and neurons of the central and peripheral nervous system. The discovery of the expression of peptide hormone genes in the nervous system has led to the suggestion that these peptides may function as neurotransmitters, neuromodulators, and releasing or inhibiting factors in different regions of the brain. Glucagon and the glucagon-like peptides are derived from proglucagon in the pancreatic islets and intestine. A role for these peptides in the central nervous system has been proposed, but evidence for the biosynthesis of proglucagon in brain has been lacking. We now report that the glucagon gene is expressed in the brainstem and hypothalamus and that a glucagon mRNA transcript identical to that produced in pancreas and intestine gives rise to proglucagon-related peptides in the brain.
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Cites
Mojsov, S., Heinrich, G., Wilson, I. B., Ravazzola, M., Orci, L., & Habener, J. F. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67324-7 · Cited by 724
Exon duplication and divergence in the human preproglucagon gene
Bell, G. I., Sanchez-Pescador, R., Laybourn, P. J., & Najarian, R. C. (1983) · Nature · doi:10.1038/304368a0 · Cited by 593
Cited by
Biology of Incretins: GLP-1 and GIP
Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639
Self-citationThe Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371
Glucagon-like peptide 1 (GLP-1)
Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868
Self-citationThe role of incretins in glucose homeostasis and diabetes treatment
Kim, W., & Egan, J. M. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000604 · Cited by 824
IMI – Report on Experimental Models of Emmetropization and Myopia
Troilo, D., Smith, E. L., Nickla, D. L., Ashby, R., Tkatchenko, A. V., Ostrin, L. A., Gawne, T. J., Pardue, M. T., Summers, J. A., Kee, C.-S., et al. (2019) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.18-25967 · Cited by 487
Metadata
- Authors
- Drucker, D. J., & Asa, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1988-09
- Volume
- 263
- Issue
- 27
- Pages
- 13475-13478
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1543470256
- Cited by
- 264
- References
- 2
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Drucker, D. J., & Asa, S. (1988). Glucagon gene expression in vertebrate brain. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)68261-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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