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Evidence for modification of lamin B by a product of mevalonic acid.
Open accessAbstract
Previous work from this laboratory has shown that a derivative of mevalonic acid is post-translationally incorporated into a number of specific proteins in Swiss 3T3 cells. Neither the nature of the modification nor the identities of the modified proteins have been determined to date. Here we describe results concerning modified proteins of approximately 67 kDa from HeLa cells and Chinese hamster ovary cells. We show that these proteins are specific to the nucleus and remain associated with a Triton/salt-insoluble nuclear fraction. Furthermore, immunological studies demonstrate that one of the modified proteins comigrates on two-dimensional gels with lamin B, a structural protein associated with the nuclear envelope. Using antibodies directed against lamin B in an immunoprecipitation experiment, we further show that this mevalonic acid-modified protein specifically coprecipitates with lamin B. These results support the hypothesis that lamin B is modified by a derivative of mevalonic acid.
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Citations
Cited by
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Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394
The discovery and development of HMG-CoA reductase inhibitors.
Endo, A. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41379-3 · Cited by 847
Targeting protein prenylation for cancer therapy
Berndt, N., Hamilton, A. D., & Sebti, S. M. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3151 · Cited by 614
Prenyl proteins in eukaryotic cells: a new type of membrane anchor
Glomset, J. A., Gelb, M. H., & Farnsworth, C. C. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90213-u · Cited by 466
Self-citationPROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS
Schafer, W. R., & Rine, J. (1992) · Annual Review of Genetics · doi:10.1146/annurev.ge.26.120192.001233 · Cited by 377
Metadata
- Authors
- Wolda, S. L., & Glomset, J. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1988-05
- Volume
- 263
- Issue
- 13
- Pages
- 5997-6000
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1564406238
- Cited by
- 252
- References
- 0
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wolda, S. L., & Glomset, J. A. (1988). Evidence for modification of lamin B by a product of mevalonic acid. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)68736-8
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