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Phosphorylation of an N-terminal Regulatory Domain Activates the CheB Methylesterase in Bacterial Chemotaxis
Open accessAbstract
Two types of reversible protein modification reactions have been identified in bacterial chemotaxis, methylation of membrane receptor-transducer proteins at glutamate side chains and phosphorylation of cytoplasmic signal transduction proteins at histidine and aspartate side chains. CheB is a bifunctional enzyme that is involved in both these modification processes. Its C-terminal domain is a methylesterase that catalyzes the hydrolysis of gamma-carboxyl glutamyl methyl esters in the cytoplasmic domain of chemoreceptor proteins. Its N-terminal domain is a phosphatase that catalyzes the hydrolysis of phospho-CheA, the central response regulator of bacterial chemotaxis. Phospho-CheB, produced as an intermediate in the phosphatase reaction, has dramatically increased methylesterase activity. The interplay between the methylesterase and phosphatase activities of CheB may provide a crucial link between adaptation and excitation in stimulus-response coupling.
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Cited by
Signal transduction schemes of bacteria
Parkinson, J. S. (1993) · Cell · doi:10.1016/0092-8674(93)90267-t · Cited by 772
HOMEOSTATIC CONTROL OF NEURAL ACTIVITY: From Phenomenology to Molecular Design
Davis, G. W. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135751 · Cited by 543
Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors.
Lukat, G. S., McCleary, W. R., Stock, A. M., & Stock, J. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.2.718 · Cited by 481
Self-citationArmitage, J. P. (1999) · Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60168-x · Cited by 271
Metadata
- Authors
- Lupas, A., & Stock, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1989-10
- Volume
- 264
- Issue
- 29
- Pages
- 17337-17342
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1556270322
- Cited by
- 194
- References
- 0
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Phosphorylation of an N-terminal Regulatory Domain Activates the CheB Methylesterase in Bacterial Chemotaxis. https://app.cochat.ai/papers/10.1016/s0021-9258(18)71497-x
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- Lupas, A., & Stock, J. (1989). Phosphorylation of an N-terminal Regulatory Domain Activates the CheB Methylesterase in Bacterial Chemotaxis. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)71497-x
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