The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors.
Open accessAbstract
Bacterial motility and gene expression are controlled by a family of phosphorylated response regulators whose activities are modulated by an associated family of protein-histidine kinases. In chemotaxis there are two response regulators, CheY and CheB, that receive phosphoryl groups from the histidine kinase, CheA. Here we show that the response regulators catalyze their own phosphorylation in that both CheY and CheB can be phosphorylated in the complete absence of any auxiliary protein. Both CheY and CheB use the N-phosphoryl group in phosphoramidate (NH2PO3(2-)) as a phospho-donor. This enzymatic activity probably reflects the general ability of response regulators to accept phosphoryl groups from phosphohistidines in their associated kinases. It provides a general method for the study of activated response regulators in the absence of kinase proteins. CheY can also use intermediary metabolites such as acetyl phosphate and carbamoyl phosphate as phospho-donors. These reactions may provide a mechanism to modulate cell behavior in response to altered metabolic states.
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Citations
Cites
Protein phosphorylation and regulation of adaptive responses in bacteria
Stock, J., Ninfa, A. J., & Stock, A. (1989) · Microbiological Reviews · doi:10.1128/mmbr.53.4.450-490.1989 · Cited by 1,707
Self-citationNinfa, A. J., & Magasanik, B. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.16.5909 · Cited by 559
Phosphorylation of three proteins in the signaling pathway of bacterial chemotaxis
Hess, J. F., Oosawa, K., Kaplan, N., & Simon, M. I. (1988) · Cell · doi:10.1016/0092-8674(88)90489-8 · Cited by 549
SIGNAL TRANSDUCTION PATHWAYS INVOLVING PROTEIN PHOSPHORYLATION IN PROKARYOTES
Bourret, R. B., Borkovich, K. A., & Simon, M. I. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.002153 · Cited by 495
Three-dimensional structure of CheY, the response regulator of bacterial chemotaxis
Stock, A. M., Mottonen, J. M., Stock, J. B., & Schutt, C. E. (1989) · Nature · doi:10.1038/337745a0 · Cited by 354
Self-citationHistidine phosphorylation and phosphoryl group transfer in bacterial chemotaxis
Hess, J. F., Bourret, R. B., & Simon, M. I. (1988) · Nature · doi:10.1038/336139a0 · Cited by 310
Identification of the site of phosphorylation of the chemotaxis response regulator protein, CheY
Sanders, D. A., Gillece-Castro, B. L., Stock, A. M., Burlingame, A. L., & Koshland, D. E. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88250-7 · Cited by 300
Self-citationNinfa, A. J., Ninfa, E. G., Lupas, A. N., Stock, A., Magasanik, B., & Stock, J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5492 · Cited by 216
Self-citationLupas, A., & Stock, J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71497-x · Cited by 194
Self-citationRole of glnB and glnD gene products in regulation of the glnALG operon of Escherichia coli
Bueno, R., Pahel, G., & Magasanik, B. (1985) · Journal of Bacteriology · doi:10.1128/jb.164.2.816-822.1985 · Cited by 184
Cited by
Wolfe, A. J. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.1.12-50.2005 · Cited by 1,233
Histidine kinases and response regulator proteins in two-component signaling systems
West, A. H., & Stock, A. M. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01852-7 · Cited by 933
Self-citationSignal transduction schemes of bacteria
Parkinson, J. S. (1993) · Cell · doi:10.1016/0092-8674(93)90267-t · Cited by 772
Stimulus Perception in Bacterial Signal-Transducing Histidine Kinases
Mascher, T., Helmann, J. D., & Unden, G. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00020-06 · Cited by 721
Ryjenkov, D. A., Tarutina, M., Moskvin, O. V., & Gomelsky, M. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.5.1792-1798.2005 · Cited by 579
Metadata
- Authors
- Lukat, G. S., McCleary, W. R., Stock, A. M., & Stock, J. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-01-15
- Volume
- 89
- Issue
- 2
- Pages
- 718-722
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2079852902
- Cited by
- 481
- References
- 22
- FWCI
- 16.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Lukat, G. S., McCleary, W. R., Stock, A. M., & Stock, J. B. (1992). Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.2.718
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
