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Complete selective absence of protamine P2 in humans
Open accessAbstract
Male sterility due to abnormal sperm morphology or motion has been widely reported, although relatively little has been published on the sperm nuclear protein abnormalities. We report the first cases worldwide of infertile patients having a complete selective absence of protamine P2 in the sperm nucleus. This provides a selective phenotype that will aid understanding of the mechanisms of synthesis, processing, or function of the P2 protamines. In addition, it is of marked immediate relevance to medicine as it allows the diagnosis of this type of human male sterility and the opportunity to understand the basis of this defect.
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Citations
Cited by
Protamines and male infertility
Oliva, R. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml009 · Cited by 802
Self-citationSperm chromatin damage impairs human fertility
Spanò, M., Bonde, J. P., Hjøllund, H. I., Kolstad, H. A., Cordelli, E., & Leter, G. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00462-8 · Cited by 719
Roest, H. P., van Klaveren, J., de Wit, J., van Gurp, C. G., Koken, M. H. M., Vermey, M., van Roijen, J. H., Hoogerbrugge, J. W., Vreeburg, J. T. M., Baarends, W. M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80154-3 · Cited by 396
Altered protamine expression and diminished spermatogenesis: what is the link?
Carrell, D. T., Emery, B. R., & Hammoud, S. (2007) · Human Reproduction Update · doi:10.1093/humupd/dml057 · Cited by 386
Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice
Yu, Y. E., Zhang, Y., Unni, E., Shirley, C. R., Deng, J. M., Russell, L. D., Weil, M. M., Behringer, R. R., & Meistrich, M. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4683 · Cited by 323
Metadata
- Authors
- de Yebra, L., Ballescà, J. L., Vanrell, J. A., Bassas, L., & Oliva, R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1993-05
- Volume
- 268
- Issue
- 14
- Pages
- 10553-10557
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1583208437
- Cited by
- 188
- References
- 0
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- de Yebra, L., Ballescà, J. L., Vanrell, J. A., Bassas, L., & Oliva, R. (1993). Complete selective absence of protamine P2 in humans. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)82234-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
