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GLYCOGEN FORMATION IN THE LIVER FROM d- AND l-LACTIC ACID
Open accessAbstract
The question as to whether or not the liver is able to form glycogen from lactic acid is of importance for the relation between the carbohydrate metabolism of the muscles and that of the liver. It is known that the process glycogen * lactic acid occurs in the muscles, while the process glycogen e glucose occurs in the liver. Glucose derived from liver glycogen is convertible into muscle glycogen; it is, however, not definitely known whether lactic acid derived from muscle glycogen is convertible into liver glycogen. If this should prove to be the case, the glucose molecule would be capable of a complete cycle in the body; it could in turn be liver glycogen, blood sugar, muscle glycogen, blood lactic acid, and again liver glycogen. If, on the other hand, the liver is unable to form glycogen (or glucose) from lactic acid, this cycle would be interrupted as soon as the glucose molecule was deposited as muscle glycogen.
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Citations
Cited by
Lactate Metabolism in Human Lung Tumors
Faubert, B., Li, K. Y., Cai, L., Hensley, C. T., Kim, J., Zacharias, L. G., Yang, C., Do, Q. N., Doucette, S., Burguete, D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.019 · Cited by 1,343
Carbohydrate metabolism in lactic acid bacteria
Kandler, O. (1983) · Antonie van Leeuwenhoek · doi:10.1007/bf00399499 · Cited by 901
Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K
Courtnay, R., Ngo, D. C., Malik, N., Ververis, K., Tortorella, S. M., & Karagiannis, T. C. (2015) · Molecular Biology Reports · doi:10.1007/s11033-015-3858-x · Cited by 567
Newgard, C. B., Hirsch, L. J., Foster, D. W., & McGarry, J. D. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82025-0 · Cited by 314
Lactate disappearance and glycogen synthesis in human muscle after maximal exercise.
Hermansen, L., & Vaage, O. (1977) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1977.233.5.e422 · Cited by 205
Metadata
- Authors
- Cori, C. F., & Cori, G. T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1929-02
- Volume
- 81
- Issue
- 2
- Pages
- 389-403
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1792813549
- Cited by
- 264
- References
- 0
- FWCI
- 18.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: GLYCOGEN FORMATION IN THE LIVER FROM d- AND l-LACTIC ACID. https://app.cochat.ai/papers/10.1016/s0021-9258(18)83822-4
- The paper
- Cori, C. F., & Cori, G. T. (1929). GLYCOGEN FORMATION IN THE LIVER FROM d- AND l-LACTIC ACID. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)83822-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
