The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway?
Open accessAbstract
To quantify the extent to which exogenous glucose is used directly or indirectly for hepatic glycogen synthesis, fasted rats were given [U-14C,3-3H] glucose intragastrically, intravenously, or as a component of a solid diet eaten ad libitum. In all cases liver glycogen was deposited at high linear rates over a 3-h period. Portal vein glucose levels seldom exceeded 8 mM. At a time when the specific activities of 3H and 14C in circulating glucose were identical with those in the administered material their values in newly synthesized glycogen were reduced by 72-88% and 50-65%, respectively. An intragastric load of unlabeled glucose sufficient to suppress completely hepatic glucose output greatly stimulated the incorporation of intravenously infused [14C]bicarbonate, [14C]lactate, [14C]alanine, and [14C] glutamine into liver glycogen. Using an improved assay the ability of liver homogenates to phosphorylate glucose at concentrations of 5-10 mM was found to be far short of what would be needed if glucose were used directly to support hepatic glycogen synthesis in vivo. These data support the notion that in the rat a major fraction of liver glycogen deposited in response to exogenous carbohydrate is formed by a pathway involving glucose leads to C3 unit leads to glycogen, although the site of the initial steps in the sequence is not yet known. The limited capacity of the liver to utilize intact glucose for glycogen synthesis might reside in its limited capacity to phosphorylate the sugar at physiological concentrations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Control of Glycogen Metabolism in the Liver
Hers, H. G. (1976) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.45.070176.001123 · Cited by 448
Chan, T. M., & Exton, J. H. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90014-2 · Cited by 413
Effects of Diet and Insulin on Glucose-Adenosine Triphosphate Phosphotransferases of Rat Liver
Sharma, C., Manjeshwar, R., & Weinhouse, S. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51797-x · Cited by 315
DeFronzo, R. A., Ferrannini, E., Hendler, R., Wahren, J., & Felig, P. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.10.5173 · Cited by 296
GLYCOGEN FORMATION IN THE LIVER FROM d- AND l-LACTIC ACID
Cori, C. F., & Cori, G. T. (1929) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83822-4 · Cited by 264
McGarry, J. D., Meier, J. M., & Foster, D. W. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44471-2 · Cited by 246
Self-citationMcGarry, J. D., Stark, M. J., & Foster, D. W. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34394-6 · Cited by 187
Self-citationGlycogen synthesis by rat hepatocytes
Katz, J., Golden, S., & Wals, P. A. (1979) · Biochemical Journal · doi:10.1042/bj1800389 · Cited by 180
THE MECHANISM OF REGULATION OF THE BLOOD SUGAR BY THE LIVER
Soskin, S., Essex, H. E., Herrick, J. F., & Mann, F. C. (1938) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1938.124.2.558 · Cited by 172
Stimulation of hepatic glycogen synthesis by amino acids.
Katz, J. J., Golden, S., & Wals, P. A. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.10.3433 · Cited by 144
Cited by
Metabolic zonation of the liver: Regulation and implications for liver function
Gebhardt, R. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90055-5 · Cited by 607
The disposal of an oral glucose load in patients with non-insulin-dependent diabetes
Ferrannini, E., Simonson, D. C., Katz, L. D., Reichard, G., Bevilacqua, S., Barrett, E. J., Olsson, M., & DeFronzo, R. A. (1988) · Metabolism · doi:10.1016/0026-0495(88)90033-9 · Cited by 305
Regulation of hepatic glucose metabolism in humans
DeFronzo, R. A., & Ferrannini, E. (1987) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610030204 · Cited by 167
Ravussin, E., Acheson, K. J., Vernet, O., Danforth, E., & Jéquier, E. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112083 · Cited by 151
Toxicity of Natural Deep Eutectic Solvent Betaine:Glycerol in Rats
Benlebna, M., Ruesgas-Ramón, M., Bonafos, B., Fouret, G., Casas, F., Coudray, C., Durand, E., Cruz Figueroa-Espinoza, M., & Feillet-Coudray, C. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b01746 · Cited by 90
Metadata
- Authors
- Newgard, C. B., Hirsch, L. J., Foster, D. W., & McGarry, J. D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1983-07
- Volume
- 258
- Issue
- 13
- Pages
- 8046-8052
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1606168019
- Cited by
- 314
- References
- 25
- FWCI
- 22.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway? https://app.cochat.ai/papers/10.1016/s0021-9258(20)82025-0
- The paper
- Newgard, C. B., Hirsch, L. J., Foster, D. W., & McGarry, J. D. (1983). Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway? Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(20)82025-0
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
