The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Studies on the Formation of Transfer Ribonucleic Acid-Ribosome Complexes
Open accessAbstract
Abstract Peptide bond formation from aminoacyl transfer RNA and ammonium chloride-washed ribosomes can occur extensively in the absence of supernatant enzymes. More than 50% of the 14C-phenylalanine-tRNA can be converted into oligophenylalanine-tRNA. Although diphenylalanine is the major product, the oligophenylalanine formed consisted of 73, 16, and 9.7% of di-, tri-, and tetraphenylalanine, respectively. Oligophenylalanine synthesis in the absence of supernatant factors (peptide bond synthesis) and amino acid polymerization into long polypeptides in the presence of supernatant (protein synthesis) differ in magnesium and temperature optima and other characteristics. Guanosine triphosphate is not required for the former as it is for the latter; the sulfhydryl inhibitor p-chloromercuribenzenesulfonate has little effect on the former while completely abolishing the latter. In addition, an absolute requirement for ammonium or potassium ions was shown for peptide bond synthesis itself. The results suggest that peptide bond synthesis from aminoacyl-tRNA is a property of ribosomes and is not mediated by supernatant protein factors.
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Citations
Cites
Catalysis of peptide bond formation by 50 s ribosomal subunits from Escherichia coli
Monro, R. E. (1967) · Journal of Molecular Biology · doi:10.1016/0022-2836(67)90271-9 · Cited by 276
Cited by
The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
Cech, T. R., & Steitz, J. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.008 · Cited by 2,524
Gavrilova, L. P., Kostiashkina, O. E., Koteliansky, V. E., Rutkevitch, N. M., & Spirin, A. S. (1976) · Journal of Molecular Biology · doi:10.1016/0022-2836(76)90243-6 · Cited by 258
Root of the Tree: The Significance, Evolution, and Origins of the Ribosome
Bowman, J. C., Petrov, A. S., Frenkel-Pinter, M., Penev, P. I., & Williams, L. D. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00742 · Cited by 197
Evolution of Protein Synthesis from an RNA World
Noller, H. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003681 · Cited by 155
Camprubí, E., de Leeuw, J. W., House, C. H., Raulin, F., Russell, M. J., Spang, A., Tirumalai, M. R., & Westall, F. (2019) · Space Science Reviews · doi:10.1007/s11214-019-0624-8 · Cited by 84
“…decoding the message from the mRNA to make the peptide (Brock et al. 1998; Ramakrishnan 2002), it was shown (as early as in 1964) that peptide synthesis initiation and subsequent steps in translation could also happen without these proteins (Nirenberg and Leder 1964; Pestka 1968; Lill et al. 1986).”
Background
Metadata
- Authors
- Pestka, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1968-05
- Volume
- 243
- Issue
- 10
- Pages
- 2810-2820
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1596738829
- Cited by
- 171
- References
- 1
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pestka, S. (1968). Studies on the Formation of Transfer Ribonucleic Acid-Ribosome Complexes. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)93445-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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