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Adenosine Triphosphate Conservation in Metabolic Regulation
Open accessAbstract
Abstract The citrate cleavage enzyme (EC 4.1.3.8) of rat liver is inhibited by adenosine diphosphate, which appears to compete with adenosine triphosphate. This effect may ensure that fatty acids are produced only when the ATP level is high. The of the adenylate system, defined as (ATP + ½ ADP)/(AMP + ADP + ATP), is proposed as a fundamental metabolic control parameter. Enzymes that utilize ATP and are inhibited by ADP or AMP will yield steep curves of velocity as a function of energy charge (resembling the steep curves of velocity as a function of substrate concentration that are characteristic of many regulatory enzymes) even in the absence of multiple sites and cooperative binding.
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Cited by
Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F., & Viollet, B. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40671 · Cited by 1,181
Metabolic control of autophagy
Galluzzi, L., Pietrocola, F., Levine, B., & Kroemer, G. (2014) · Cell · doi:10.1016/j.cell.2014.11.006 · Cited by 855
Control of antibiotic biosynthesis
Martin, J. F., & Demain, A. L. (1980) · Microbiological Reviews · doi:10.1128/mmbr.44.2.230-251.1980 · Cited by 560
The role of fatty acid β-oxidation in lymphangiogenesis
Wong, B. W., Wang, X., Zecchin, A., Thienpont, B., Cornelissen, I., Kalucka, J., García-Caballero, M., Missiaen, R., Huang, H., Brüning, U., et al. (2017) · Nature · doi:10.1038/nature21028 · Cited by 336
Inositol pyrophosphates: between signalling and metabolism
Wilson, M. S. C., Livermore, T. M., & Saiardi, A. (2013) · Biochemical Journal · doi:10.1042/bj20130118 · Cited by 256
Metadata
- Authors
- Atkinson, D. E., & Walton, G. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1967-07
- Volume
- 242
- Issue
- 13
- Pages
- 3239-3241
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1587804137
- Cited by
- 903
- References
- 0
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
