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The Inhibition of Mitochondrial Peroxidation by Ubiquinone and Ubiquinol
Open accessAbstract
Ubiquinol-6 (reduced coenzyme Q6) was more effective than ubiquinone-6 and almost as effective as α-tocopherol in reducing the stable free radical diphenyl-p-picrylhydrazyl. The antioxidant activity of ubiquinol-6 was measured at low oxygen concentrations with an oxygen electrode. Ubiquinol-6 was found to be as efficient as α-tocopherol as an inhibitor of the heme-catalyzed peroxidation of arachidonic acid emulsions. Ubiquinol-6 was oxidized to ubiquinone-6 by free radical products of the heme-catalyzed decomposition of cumene hydroperoxide. α-Tocopherol did not inhibit this reaction. Light was used to catalyze the peroxidation of mitochondrial lipids at low concentrations of oxygen. This peroxidation was inhibited by the addition of ubiquinol-6 or α-tocopherol to the mitochondria. Light-induced mitochondrial peroxidation was inhibited by ubiquinol-6 produced from exogenous ubiquinone-6 by the electron transport-linked oxidation of β-hydroxybutyrate. Ubiquinols may function as antioxidants in the mitochondrion. This could explain why ubiquinones and related compounds have been found effective in the relief of certain vitamin E deficiency syndromes in some species.
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Cited by
Biochemical, physiological and medical aspects of ubiquinone function
Ernster, L., & Dallner, G. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00028-3 · Cited by 1,227
YAMAGUCHI, T., TAKAMURA, H., MATOBA, T., & TERAO, J. (1998) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.62.1201 · Cited by 1,107
Metabolism and function of coenzyme Q
Turunen, M., Olsson, J., & Dallner, G. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2003.11.012 · Cited by 1,026
Burton, G. W., Joyce, A., & Ingold, K. U. (1983) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(83)90145-5 · Cited by 802
Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.
Frei, B., Kim, M. C., & Ames, B. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4879 · Cited by 620
Metadata
- Authors
- Mellors, A., & Tappel, A. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1966-10
- Volume
- 241
- Issue
- 19
- Pages
- 4353-4356
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1923689855
- Cited by
- 430
- References
- 0
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Mellors, A., & Tappel, A. L. (1966). The Inhibition of Mitochondrial Peroxidation by Ubiquinone and Ubiquinol. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)99728-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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