The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Full-length sequence of the cDNA for human erythroid beta-spectrin.
Open accessAbstract
Spectrin is the major molecular consituent of the red cell membrane skeleton. We have isolated overlapping human erythroid beta-spectrin cDNA clones and determined 6773 base pairs of contiguous nucleotide sequence. This includes the entire coding sequence of beta-spectrin. The sequence translates into a 2137 amino acid, 246-kDa peptide. beta-Spectrin is found to consist of three distinct domains. Domain I, at the N terminus, is a 272-amino acid region lacking resemblance to the spectrin repetitive motif. Sequences in this region exhibit striking sequence homology, at both nucleotide and amino acid levels, to the N-terminal "actin-binding" domains of alpha-actinin and dystrophin. Between residues 51 and 270 there is 55% amino acid identity to human dystrophin, with only four single amino acid gaps in alignment. Domain II consists of 17 spectrin repeats. Several sequence variations are observed in typical repeat structure. Homology to alpha-actinin extends beyond domain I into the N-terminal portion of domain II. Domain III, 52 amino acid residues at the C terminus, does not adhere to the spectrin repeat motif. Combining knowledge of spectrin primary structure with previously reported functional studies, it is possible to make several inferences regarding structure/function relationships within the beta-spectrin molecule.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dystrophin: the protein product of the Duchenne muscular dystrophy locus
Hoffman, E. P., Brown, R. H., & Kunkel, L. M. (1987) · Cell · doi:10.1016/0092-8674(87)90579-4 · Cited by 4,693
Cited by
Spectrin and Ankyrin-Based Pathways: Metazoan Inventions for Integrating Cells Into Tissues
Bennett, V., & Baines, A. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1353 · Cited by 930
Hartwig, J. H., & Kwiatkowski, D. J. (1991) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(91)90170-4 · Cited by 287
Berghs, S., Aggujaro, D., Dirkx, R., Maksimova, E., Stabach, P., Hermel, J.-M., Zhang, J.-P., Philbrick, W., Slepnev, V., Ort, T., et al. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.5.985 · Cited by 275
A Novel Brain-Specific Isoform of β Spectrin: Isolation and Its Interaction with Munc13
Sakaguchi, G., Orita, S., Naito, A., Maeda, M., Igarashi, H., Sasaki, T., & Takai, Y. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9067 · Cited by 58
Effects of dextran on the self-association of human spectrin
Lindner, R., & Ralston, G. (1995) · Biophysical Chemistry · doi:10.1016/0301-4622(95)00063-4 · Cited by 46
Metadata
- Authors
- Winkelmann, J. C., Chang, J. G., Tse, W. T., Scarpa, A. L., Marchesi, V. T., & Forget, B. G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1990-07
- Volume
- 265
- Issue
- 20
- Pages
- 11827-11832
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1489771083
- Cited by
- 234
- References
- 1
- FWCI
- 16.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Full-length sequence of the cDNA for human erythroid beta-spectrin. https://app.cochat.ai/papers/10.1016/s0021-9258(19)38473-x
- The paper
- Winkelmann, J. C., Chang, J. G., Tse, W. T., Scarpa, A. L., Marchesi, V. T., & Forget, B. G. (1990). Full-length sequence of the cDNA for human erythroid beta-spectrin. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)38473-x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
