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Activation of Na+ and K+ pumping modes of (Na, K)-ATPase by an oscillating electric field
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Serpersu and Tsong (Sepersu, E. H., and Tsong, T. Y. (1983) J. Membr. Biol. 74, 191-201; (1984) J. Biol. Chem. 259, 7155-7162) reported activation of a K+ pumping mode of (Na,K)-ATPase by an oscillating electric field (20 V/cm, 1.0 kHz). Their attempts to activate Na+ pumping at the same frequency were unsuccessful. We report here activation of a Na+ pumping mode with an oscillating electric field of the same strength as used previously (20 V/cm) but at a much higher frequency (1.0 MHz). At 3.5 degrees C and the optimal amplitude and frequency, the field-induced, ouabain-sensitive (0.2 mM ouabain incubated for 30 min) Rb+ influx ranged between 10 and 20 amol/red blood cell/h, and the corresponding Na+ efflux ranged between 15 and 30 amol/red blood cell/h, varying with the source of the erythrocytes. No Rb+ efflux nor Na+ influx was stimulated by the applied field in the frequency range 1 Hz to 10 MHz. These results indicate that only those transport modes that require ATP splitting under the physiological condition were affected by the applied electric fields, although the field-stimulated Rb+ influx and Na+ efflux did not depend on the cellular ATP concentration in the range 5 to 800 microM. Computer simulation of a four-state enzyme electroconformationally coupled to an alternating electric field (Tsong, T. Y., and Astumian, R. D. (1986) Bioelectrochem. Bioenerg. 15, 457-476; Tsong, T. Y. (1990) Annu. Rev. Biophys. Biophys. Chem. 19, 83-106) reproduced the main features of the above results.
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“Moreover, neither K+ efflux nor Na+ influx was stimulated by the applied field in the frequency range from 1 Hz to 10 MHz.”
From An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields (2016) · cites this paper as [80]
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Metadata
- Authors
- Liu, D. S., Astumian, R. D., & Tsong, T. Y.
- Affiliations
- University of Minnesota (US)
- ORCID
- Astumian, R D
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1990-05
- Volume
- 265
- Issue
- 13
- Pages
- 7260-7267
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1608844245
- Cited by
- 199
- References
- 43
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 10 · 2015: 2 · 2012: 4
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Keywords
- Na+/K+-ATPase, oscillating electric field, Na+ efflux, erythrocytes, ouabain sensitivity, ATP hydrolysis, erythrocyte membrane
- MeSH terms
- Sodium-Potassium-Exchanging ATPase, Adenosine Triphosphate, Biological Transport, Active, Electric Stimulation, Erythrocytes, Humans, Kinetics, Mathematics, Models, Theoretical, Ouabain, Potassium, Rubidium, Sodium, Spectrometry, Fluorescence
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