Cited by 199Ion Transport and Channel RegulationATP Synthase and ATPases ResearchElectromagnetic Fields and Biological Effects

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Activation of Na+ and K+ pumping modes of (Na, K)-ATPase by an oscillating electric field

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Liu, D S, Astumian, R D, Tsong, T Y·1990·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(19)39108-2

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Abstract

Serpersu and Tsong (Sepersu, E. H., and Tsong, T. Y. (1983) J. Membr. Biol. 74, 191-201; (1984) J. Biol. Chem. 259, 7155-7162) reported activation of a K+ pumping mode of (Na,K)-ATPase by an oscillating electric field (20 V/cm, 1.0 kHz). Their attempts to activate Na+ pumping at the same frequency were unsuccessful. We report here activation of a Na+ pumping mode with an oscillating electric field of the same strength as used previously (20 V/cm) but at a much higher frequency (1.0 MHz). At 3.5 degrees C and the optimal amplitude and frequency, the field-induced, ouabain-sensitive (0.2 mM ouabain incubated for 30 min) Rb+ influx ranged between 10 and 20 amol/red blood cell/h, and the corresponding Na+ efflux ranged between 15 and 30 amol/red blood cell/h, varying with the source of the erythrocytes. No Rb+ efflux nor Na+ influx was stimulated by the applied field in the frequency range 1 Hz to 10 MHz. These results indicate that only those transport modes that require ATP splitting under the physiological condition were affected by the applied electric fields, although the field-stimulated Rb+ influx and Na+ efflux did not depend on the cellular ATP concentration in the range 5 to 800 microM. Computer simulation of a four-state enzyme electroconformationally coupled to an alternating electric field (Tsong, T. Y., and Astumian, R. D. (1986) Bioelectrochem. Bioenerg. 15, 457-476; Tsong, T. Y. (1990) Annu. Rev. Biophys. Biophys. Chem. 19, 83-106) reproduced the main features of the above results.

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Tsong, T. Y. (1990) · Journal of Electroanalytical Chemistry · doi:10.1016/0022-0728(90)87529-s · Cited by 24
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Tsong, T. Y. (1992) · Elsevier eBooks · doi:10.1016/b978-0-08-091727-6.50007-1 · Cited by 24
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“The rigid requirements for such clock-like coupling have recently been challenged by experiments of Tsong and colleagues (Liu et al. 1990; Xie et al. 1994) on Na,KATPase.”
BackgroundMethod
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Amiali, M., & Ngadi, M. O. (2012) · Elsevier eBooks · doi:10.1533/9780857095756.2.407 · Cited by 22
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Ion channel enzyme in an oscillating electric field
Markin, V., Liu, D., Gimsa, J., Strobel, R. S., Rosenberg, M. D., & Tsong, T. Y. (1992) · The Journal of Membrane Biology · doi:10.1007/bf00231912 · Cited by 22
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“In the preceding investigations, an electroconformational coupling (ECC) model for membrane transport was developed which could transduce the energy of an oscillating electrical field into the concentration gradient of a ligand (1-12).”
Background
Electroconformational coupling for ion transport in an oscillating electric field: rectification versus active pumping
Markin, V. S., & Tsong, T. Y. (1991) · Journal of Electroanalytical Chemistry · doi:10.1016/0022-0728(91)85600-t · Cited by 21
On the nonlinear dielectric properties of biological systems
Woodward, A. M., & Kell, D. B. (1990) · Journal of Electroanalytical Chemistry · doi:10.1016/0022-0728(90)87511-h · Cited by 20
Effect of externally applied electrostatic fields on the surface topography of ceramide-enriched domains in mixed monolayers with sphingomyelin
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Electrowetting of Weak Polyelectrolyte-Coated Surfaces
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Awasthi, K., Nakabayashi, T., & Ohta, N. (2016) · ACS Omega · doi:10.1021/acsomega.6b00090 · Cited by 16
Interaction of low level modulated RF radiation with Na+–K+-ATPase
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Authors: Liu, D. S., Astumian, R. D., & Tsong, T. Y.
Affiliations: University of Minnesota (US)
ORCID: Astumian, R D
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1990-05
Volume: 265
Issue: 13
Pages: 7260-7267
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(19)39108-2
OpenAlex: W1608844245
Cited by: 199
References: 43
Citations by year: 2026: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 10 · 2015: 2 · 2012: 4
FWCI: 5.84
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 11130 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
Keywords: Na+/K+-ATPase, oscillating electric field, Na+ efflux, erythrocytes, ouabain sensitivity, ATP hydrolysis, erythrocyte membrane
MeSH terms: Sodium-Potassium-Exchanging ATPase, Adenosine Triphosphate, Biological Transport, Active, Electric Stimulation, Erythrocytes, Humans, Kinetics, Mathematics, Models, Theoretical, Ouabain, Potassium, Rubidium, Sodium, Spectrometry, Fluorescence

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Activation of Na+ and K+ pumping modes of (Na, K)-ATPase by an oscillating electric field

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