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Isolation and characterization of a manganese-containing superoxide dismutase from yeast.
Open accessAbstract
The cyanide-insensitive superoxide dismutase of yeast has been shown to be localized in the mitochondrial matrix. This enzyme has been isolated in good yield from bakers' yeast. Its molecular weight is 96,000. It is a tetramer, being composed of four subunits of equal size. Exposure to sodium dodecyl sulfate at 100 degrees caused dissociation into dimers, while similar treatment but in the presence of 2-mercaptoethanol caused complete dissociation into monomers. This enzyme contains 1 atom of manganese per subunit and its absorption in the visible suggests Mn(III) in the resting enzyme. Ascorbate caused partial bleaching, presumably by reduction to Mn(II). The amino acid composition was determined. This enzyme has activity comparable to that of other previously reported superoxide dismutases and like the chicken mitochondrial and the bacterial enzymes, its rate of reaction with O2 falls as the pH is raised above 7.8. Crystals of high quality were easily prepared.
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Citations
Cites
Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels
Beauchamp, C., & Fridovich, I. (1971) · Analytical Biochemistry · doi:10.1016/0003-2697(71)90370-8 · Cited by 12,892
Self-citationWeisiger, R. A., & Fridovich, I. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43969-0 · Cited by 895
Self-citation
Cited by
Superoxide radical and superoxide dismutases
Fridovich, I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000525 · Cited by 3,455
Self-citationFridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329
Manganese Superoxide Dismutase: Guardian of the Powerhouse
Holley, A. K., Bakthavatchalu, V., Velez-Roman, J. M., & St. Clair, D. K. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12107114 · Cited by 358
Antioxidant enzymes in the digestive gland of the common mussel Mytilus edulis
Livingstone, D. R., Lips, F., Martinez, P. G., & Pipe, R. K. (1992) · Marine Biology · doi:10.1007/bf00702471 · Cited by 342
Culotta, V. C., & Daly, M. J. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5093 · Cited by 167
Metadata
- Authors
- Ravindranath, S. D., & Fridovich, I.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1975-08
- Volume
- 250
- Issue
- 15
- Pages
- 6107-6112
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1498131095
- Cited by
- 182
- References
- 2
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ravindranath, S. D., & Fridovich, I. (1975). Isolation and characterization of a manganese-containing superoxide dismutase from yeast. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)41165-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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