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The Mode of Action of Vitamin K
Open accessAbstract
Abstract An unusual tryptic peptide isolated from the protein, prothrombin, has recently been shown to contain at least a portion of the vitamin K-dependent region of this protein (Nelsestuen, G. L., and Suttie, J. W. (1973) Proc. Nat. Acad. Sci. U. S. A. 70, 3366–3370). A modified glutamylserine dipeptide has been isolated from proteolytic digests of this vitamin K-dependent peptide and has been characterized. It has been unambiguously demonstrated that the glutamic acid of the glutamylserine has been substituted by carboxylation of the γ carbon atom so that the dipeptide structure is: [see PDF for equation] Presumably, the incorporation of the second γ-carboxyl group is dependent on vitamin K.
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Cited by
Pharmacology and Management of the Vitamin K Antagonists
Ansell, J., Hirsh, J., Hylek, E., Jacobson, A., Crowther, M., & Palareti, G. (2008) · Chest · doi:10.1378/chest.08-0670 · Cited by 2,118
New trends in encapsulation of liposoluble vitamins
Gonnet, M., Lethuaut, L., & Boury, F. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.01.037 · Cited by 334
Osteocalcin: Isolation, characterization, and detection
Gundberg, C. M., Hauschka, P. V., Lian, J. B., & Gallop, P. M. (1984) · Methods in Enzymology · doi:10.1016/0076-6879(84)07036-1 · Cited by 332
A new carboxylation reaction. The vitamin K-dependent incorporation of H-14-CO3- into prothrombin.
Esmon, C. T., Sadowski, J. A., & Suttie, J. W. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41365-3 · Cited by 271
Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources
Song, L., & Zhang, S. (2023) · Biomolecules · doi:10.3390/biom13111600 · Cited by 58
Metadata
- Authors
- Nelsestuen, G. L., Zytkovicz, T. H., & Howard, J. B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1974-10
- Volume
- 249
- Issue
- 19
- Pages
- 6347-6350
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1782728159
- Cited by
- 528
- References
- 0
- FWCI
- 32.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nelsestuen, G. L., Zytkovicz, T. H., & Howard, J. B. (1974). The Mode of Action of Vitamin K. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)42259-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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