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Cited by 58Phytochemicals and Antioxidant ActivitiesGenetics, Aging, and Longevity in Model OrganismsAntioxidants, Aging, Portulaca oleracea

Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources

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Song, Lili, Zhang, Shicui·2023·Biomolecules
DOI 10.3390/biom13111600PMC PMC10669485
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Abstract

Aging is a natural and inescapable phenomenon characterized by a progressive deterioration of physiological functions, leading to increased vulnerability to chronic diseases and death. With economic and medical development, the elderly population is gradually increasing, which poses a great burden to society, the economy and the medical field. Thus, healthy aging has now become a common aspiration among people over the world. Accumulating evidence indicates that substances that can mediate the deteriorated physiological processes are highly likely to have the potential to prolong lifespan and improve aging-associated diseases. Foods from natural sources are full of bioactive compounds, such as polysaccharides, polyphenols, carotenoids, sterols, terpenoids and vitamins. These bioactive compounds and their derivatives have been shown to be able to delay aging and/or improve aging-associated diseases, thereby prolonging lifespan, via regulation of various physiological processes. Here, we summarize the current understanding of the anti-aging activities of the compounds, polysaccharides, polyphenols, carotenoids, sterols, terpenoids and vitamins from natural food sources, and their modes of action in delaying aging and improving aging-associated diseases. This will certainly provide a reference for further research on the anti-aging effects of bioactive compounds from natural food sources.

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  • PDRN activates the ERK and PI3K/AKT signaling pathways, thereby suppressing MITF.

    “Mechanistically, PDRN activates the ERK and phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathways, thereby suppressing microphthalmia-associated transcription factor (MITF), a master regulator of melanocyte function [102,103].”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [102]

    Section 2.6 (Vitamins; page unavailable) reports that PVN, a formula containing PDRN, vitamin C, and niacinamide, decreased MITF expression in UV-B-radiated animal skin. It does not attribute that effect to PDRN alone or say that PDRN activates ERK and PI3K/AKT to suppress MITF. (LLM, conf=0.86)

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Sorted by citations

Authors
Song, L., & Zhang, S.
Affiliations
  • Hebei North University (CN)
  • Kashi University (CN)
Corresponding author
Zhang, Shicui
ORCID
Venue
Biomolecules
Publisher
MDPI AG
Published
2023-10-31
Volume
13
Issue
11
Pages
1600
ISSN
2218-273X (ISSN-L)
DOI
10.3390/biom13111600
PMC
PMC10669485
OpenAlex
W4388041798
Cited by
58
References
14
Citations by year
2026: 12 · 2025: 33 · 2024: 13
FWCI
1.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomolecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • The Science and Technology Research Project of Hebei Higher Education Institutions (QN2023099, 022023184)
  • Initiative Research Fund of Kashi University (QN2023099, 022023184)
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords
anti-aging effects, healthy aging, bioactive compounds, natural food sources, polysaccharides, polyphenols, carotenoids, sterols, terpenoids, vitamins, age-related diseases, lifespan extension, mechanism of action
MeSH terms
Aged, Aging, Carotenoids, Humans, Polysaccharides, Sterols, Terpenes, Vitamins, Polyphenols

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