The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami
Open accessAbstract
Abstract A hypotensive peptide, designated neurotensin, has been discovered and isolated in pure form from acid-acetone extracts of bovine hypothalami by column chromatography and paper electrophoresis. The results of amino acid analyses of material recovered after paper electrophoresis at pH 3.5, 6.5, and 8.9 and chromatographic analyses of the dansylated material indicate that the peptide isolated by this procedure is homogenous. Its amino acid composition and apparent molecular weight estimated by chromatography on Sephadex G-25 indicate that neurotensin is a tridecapeptide composed of Lys, Arg2, Asx, Glx2, Pro2, Ileu, Leu2, Tyr2. Neurotensin lacks a free NH2-terminus; however, it possesses a free COOH terminus which can be acted upon by carboxypeptidase A. Neurotensin induces hypotension in the rat and can stimulate the contraction of guinea pig ileum and rat uterus; however, it produces relaxation of the rat duodenum. These pharmacological properties classify it as a kinin, yet its chemical composition distinguishes it from any known peptide.
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Cites
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THE OXIDATION OF RIBONUCLEASE WITH PERFORMIC ACID
Hirs, C. H. W. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65721-7 · Cited by 1,857
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Hartley, B. S. (1970) · Biochemical Journal · doi:10.1042/bj1190805f · Cited by 1,225
Electrophoretic Mobilities of Peptides on Paper and their Use in the Determination of Amide Groups
OFFORD, R. E. (1966) · Nature · doi:10.1038/211591a0 · Cited by 1,006
Chang, M. M., & Leeman, S. E. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62860-1 · Cited by 696
Self-citationTechniques in protein chemistry
Pataki, G. (1967) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)86077-5 · Cited by 660
Study of the Dansylation Reaction of Amino Acids, Peptides and Proteins
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Schally, A. V., Arimura, A., & Kastin, A. J. (1973) · Science · doi:10.1126/science.179.4071.341 · Cited by 572
The oestrous cycle in the rat and its associated phenomena
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[52] Sequential degradation plus dansylation
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Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Neuromodulation of neuronal circuits: back to the future
Marder, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.010 · Cited by 904
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Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?
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Metadata
- Authors
- Carraway, R., & Leeman, S. E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1973-10
- Volume
- 248
- Issue
- 19
- Pages
- 6854-6861
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1607957872
- Cited by
- 1,537
- References
- 16
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Carraway, R., & Leeman, S. E. (1973). The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)43429-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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