Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6
Open accessAbstract
Autism spectrum disorders (ASDs) have been associated with brain inflammation as indicated by microglia activation, as well as brain expression and increased plasma levels of interleukin-6 (IL-6) and tumor necrosis factor (TNF). Here we report that serum levels of IL-6 and TNF were elevated (61.95±94.76 pg ml−1 and 313.8±444.3 pg ml−1, respectively) in the same cohort of patients with elevated serum levels of corticotropin-releasing hormone (CRH) and neurotensin (NT), while IL-9, IL-31 and IL-33 were not different from controls. The elevated CRH and NT levels did not change after treatment with a luteolin-containing dietary formulation. However, the mean serum IL-6 and TNF levels decreased significantly (P=0.036 and P=0.015, respectively) at the end of the treatment period (26 weeks) as compared with levels at the beginning; these decreases were strongly associated with children whose behavior improved the most after luteolin formulation treatment. Our results indicate that there are distinct subgroups of children within the ASDs that may be identifiable through serum levels of IL-6 and TNF and that these cytokines may constitute distinct prognostic markers for at least the beneficial effect of luteolin formulation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several pre-clinical and clinical studies found increased levels of inflammatory markers in the systemic circulation of ASD individuals when compared to neurotypical controls, such as increased IL-1B and heightened systemic TNF-alpha.
“Several pre-clinical and clinical studies found increased levels of inflammatory markers in the systemic circulation of ASD individuals when compared to neurotypical controls, such as increased IL-1B [107, 108] and heightened systemic TNF-alpha [108–110].”
From Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders (2022) · cites this paper as [110]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882 · see citing works
Self-citationNeuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · see citing works
Identification and Evaluation of Children With Autism Spectrum Disorders
Johnson, C. P., Myers, S. M., & and the Council on Children With Disabilities (2007) · Pediatrics · doi:10.1542/peds.2007-2361 · Cited by 2,011 · see citing works
Epidemiology of Pervasive Developmental Disorders
Fombonne, E. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e31819e7203 · Cited by 1,971 · see citing works
Advances in autism genetics: on the threshold of a new neurobiology
Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866 · see citing works
The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami
Carraway, R. E., & Leeman, S. E. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43429-7 · Cited by 1,543 · see citing works
Immune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483 · see citing works
Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.164 · Cited by 1,356 · see citing works
Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
Hollman, P. C. H., de Vries, J., van Leeuwen, S., Mengelers, M. J. B., & Katan, M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1276 · Cited by 956 · see citing works
Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.08.003 · Cited by 940 · see citing works
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.136 · Cited by 913 · see citing works
Harwood, M., Danielewska-Nikiel, B., Borzelleca, J. F., Flamm, G., Williams, G. M., & Lines, T. C. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.05.015 · Cited by 890 · see citing works
Buie, T., Campbell, D. B., Fuchs, G. J., Furuta, G. T., Levy, J., VandeWater, J., Whitaker, A. H., Atkins, D., Bauman, M. L., Beaudet, A. L., et al. (2010) · Pediatrics · doi:10.1542/peds.2009-1878c · Cited by 872 · see citing works
Elevated immune response in the brain of autistic patients
Li, X., Chauhan, A., Sheikh, A. M., Patil, S., Chauhan, V., Li, X.-M., Ji, L., Brown, T., & Malik, M. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.12.002 · Cited by 786 · see citing works
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
Jang, S., Liu, X., Yepes, M., Shepherd, K. R., Miller, G. W., Liu, Y., Wilson, W. D., Xiao, G., Blanchi, B., Sun, Y. E., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913572107 · Cited by 689 · see citing works
Absorption, metabolism and health effects of dietary flavonoids in man
Hollman, P., & Katan, M. (1997) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(97)88045-6 · Cited by 609 · see citing works
Hagberg, H., Gressèns, P., & Mallard, C. E. (2011) · Annals of Neurology · doi:10.1002/ana.22620 · Cited by 519 · see citing works
Mast Cells, Mastocytosis, and Related Disorders
Theoharides, T. C., Valent, P., & Akin, C. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1409760 · Cited by 518 · see citing works
Self-citationGupta, S., Ellis, S. E., Ashar, F. N., Moes, A., Bader, J. S., Zhan, J., West, A. B., & Arking, D. E. (2014) · Nature Communications · doi:10.1038/ncomms6748 · Cited by 504 · see citing works
Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis
Masi, A., Quintana, D. S., Glozier, N., Lloyd, A. R., Hickie, I. B., & Guastella, A. J. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.59 · Cited by 467 · see citing works
Environmental toxicants and autism spectrum disorders: a systematic review
Rossignol, D. A., Genuis, S. J., & Frye, R. E. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.4 · Cited by 458 · see citing works
Theoharides, T. C., Singh, L. K., Boucher, W. S., Pang, X., Létourneau, R., Webster, E., & Chrousos, G. P. (1998) · Endocrinology · doi:10.1210/endo.139.1.5660 · Cited by 447 · see citing works
Self-citationGurney, J. G., McPheeters, M. L., & Davis, M. M. (2006) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.160.8.825 · Cited by 411 · see citing works
Immune transcriptome alterations in the temporal cortex of subjects with autism
Garbett, K., Ebert, P. J., Mitchell, A., Lintas, C., Manzi, B., Mirnics, K., & Persico, A. M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.01.012 · Cited by 375 · see citing works
Jang, S., Kelley, K. W., & Johnson, R. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802865105 · Cited by 365 · see citing works
Griffin, G. K., Newton, G., Tarrio, M. L., Bu, D.-X., Maganto-Garcia, E., Azcutia, V., Alcaide, P., Grabie, N., Luscinskas, F. W., Croce, K. J., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200385 · Cited by 364 · see citing works
Herbert, M. R. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328336a01f · Cited by 356 · see citing works
Modeling an autism risk factor in mice leads to permanent immune dysregulation
Hsiao, E. Y., McBride, S. W., Chow, J., Mazmanian, S. K., & Patterson, P. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202556109 · Cited by 340 · see citing works
Kempuraj, D., Madhappan, B., Christodoulou, S., Boucher, W. S., Cao, J., Papadopoulou, N., Cetrulo, C. L., & Theoharides, T. C. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706246 · Cited by 336 · see citing works
Self-citationJäger, A. K., & Saaby, L. (2011) · Molecules · doi:10.3390/molecules16021471 · Cited by 333 · see citing works
Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells
Park, H.-H., Lee, S., Son, H., Park, S.-B., Kim, M.-S., Choi, E., Singh, T. S. K., Ha, J., Lee, M., Kim, J., et al. (2008) · Archives of Pharmacal Research · doi:10.1007/s12272-001-2110-5 · Cited by 329 · see citing works
How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis
Deth, R., Muratore, C., Benzecry, J., Power-Charnitsky, V.-A., & Waly, M. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2007.09.010 · Cited by 325 · see citing works
Elevation of Tumor Necrosis Factor-Alpha in Cerebrospinal Fluid of Autistic Children
Chez, M. G., Dowling, T., Patel, P. B., Khanna, P., & Kominsky, M. (2007) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2007.01.012 · Cited by 317 · see citing works
Kimata, M., Shichijo, Miura, M., Serizawa, Inagaki, & Nagaĭ (2000) · PubMed · doi:10.1046/j.1365-2222.2000.00768.x · Cited by 314 · see citing works
Cerebrospinal Fluid and Serum Markers of Inflammation in Autism
Zimmerman, A. W., Jyonouchi, H., Comi, A. M., Connors, S. L., Milstien, S., Varsou, A., & Heyes, M. P. (2005) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2005.03.014 · Cited by 300 · see citing works
Altered T cell responses in children with autism
Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I. N., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.09.002 · Cited by 281 · see citing works
An infection-based model of neurodevelopmental damage
Hornig, M., Weißenböck, H., Horscroft, N., & Lipkin, W. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12102 · Cited by 265 · see citing works
Mast cells enhance T cell activation: Importance of mast cell-derived TNF
Nakae, S., Suto, H., Kakurai, M., Sedgwick, J. D., Tsai, M. M., & Galli, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501912102 · Cited by 254 · see citing works
Mast cells, glia and neuroinflammation: partners in crime?
Skaper, S. D., Facci, L., & Giusti, P. (2013) · Immunology · doi:10.1111/imm.12170 · Cited by 251 · see citing works
Taliou, A., Zintzaras, E., Lykouras, L., & Francis, K. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.04.006 · Cited by 235 · see citing works
Self-citationInflammatory Cytokines: Potential Biomarkers of Immunologic Dysfunction in Autism Spectrum Disorders
Xu, N., Li, X., & Zhong, Y. (2015) · Mediators of Inflammation · doi:10.1155/2015/531518 · Cited by 223 · see citing works
Metabolism of Flavonoids in Human: A Comprehensive Review
Chen, Z., Zheng, S., Li, L., & Jiang, H. (2014) · Current Drug Metabolism · doi:10.2174/138920021501140218125020 · Cited by 217 · see citing works
Sharma, V., Mishra, M., Ghosh, S., Tewari, R., Basu, A., Seth, P., & Sen, E. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.01.016 · Cited by 202 · see citing works
Elevated serum levels of interleukin-17A in children with autism
AL-Ayadhi, L. Y., & Mostafa, G. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-158 · Cited by 193 · see citing works
Gilmore, J. H., Jarskog, L. F., & Vadlamudi, S. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.10.008 · Cited by 177 · see citing works
Dirscherl, K., Karlstetter, M., Ebert, S., Kraus, D., Hlawatsch, J., Walczak, Y., Moehle, C., Fuchshofer, R., & Langmann, T. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-3 · Cited by 175 · see citing works
Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice
Jang, S., Dilger, R. N., & Johnson, R. W. (2010) · Journal of Nutrition · doi:10.3945/jn.110.123273 · Cited by 154 · see citing works
Evaluation for Safety of Antioxidant Chemopreventive Agents
Kawanishi, S., Oikawa, S., & Murata, M. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1728 · Cited by 152 · see citing works
TNF Trafficking to Human Mast Cell Granules: Mature Chain-Dependent Endocytosis
Olszewski, M. B., Groot, A. J., Dastych, J., & Knol, E. F. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5701 · Cited by 151 · see citing works
Chen, H.-Q., Jin, Z., Wang, X., Xu, X., Deng, L., & Zhao, J.-W. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.10.046 · Cited by 150 · see citing works
Zhang, B., Alysandratos, K., Angelidou, A., Asadi, S., Sismanopoulos, N., Delivanis, D.-A., Weng, Z., Miniati, A., Vasiadi, M., Katsarou‐Katsari, A., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.02.005 · Cited by 142 · see citing works
Self-citationDonelan, J., Boucher, W. S., Papadopoulou, N., Lytinas, M., Papaliodis, D., Dobner, P. R., & Theoharides, T. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602210103 · Cited by 142 · see citing works
Self-citationThe novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells
Weng, Z., Patel, A., Panagiotidou, S., & Theoharides, T. C. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.10.032 · Cited by 141 · see citing works
Self-citationMast cells promote Th1 and Th17 responses by modulating dendritic cell maturation and function
Dudeck, A., Suender, C. A., Kostka, S. L., von Stebut, E., & Maurer, M. (2011) · European Journal of Immunology · doi:10.1002/eji.201040994 · Cited by 140 · see citing works
Mast cells, brain inflammation and autism
Theoharides, T. C., Stewart, J. M., Panagiotidou, S., & Melamed, I. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.086 · Cited by 138 · see citing works
Self-citationThe role of neurotensin in physiologic and pathologic processes
Mustain, W. C., Rychahou, P. G., & Evers, B. M. (2011) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283419052 · Cited by 136 · see citing works
Mast cell activation and autism
Theoharides, T. C., Angelidou, A., Alysandratos, K.-D., Zhang, B., Asadi, S., Francis, K., Toniato, E., & Kalogeromitros, D. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.017 · Cited by 125 · see citing works
Self-citationMcPartland, J. C., & Volkmar, F. R. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00023-1 · Cited by 117 · see citing works
Parker-Athill, E. C., Luo, D., Bailey, A. R., Giunta, B. N., Tian, J., Shytle, R. D., Murphy, T. K., Légrádi, G., & Tan, J. R. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.08.012 · Cited by 111 · see citing works
Kempuraj, D., Tagen, M., Iliopoulou, B. P., Clemons, A., Vasiadi, M., Boucher, W. S., House, M. D., Wolfberg, A., & Theoharides, T. C. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.356 · Cited by 109 · see citing works
Self-citation7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome
Johnson, R. A., Lam, M. S. Y., Punzo, A. M., Li, H., Lin, B. R., Ye, K., Mitchell, G. S., & Chang, Q. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01361.2011 · Cited by 108 · see citing works
Neuro-Inflammation, Blood-Brain Barrier, Seizures and Autism
Theoharides, T. C., & Zhang, B. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-168 · Cited by 108 · see citing works
Self-citationHuang, M. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00340-7 · Cited by 96 · see citing works
Verbal ability, social stress, and anxiety in children with Autistic Disorder
Lanni, K. E., Schupp, C. W., Simon, D. M., & Corbett, B. A. (2011) · Autism · doi:10.1177/1362361311425916 · Cited by 92 · see citing works
Luteolin inhibits cytokine expression in endotoxin/cytokine-stimulated microglia
Kao, T.-K., Ou, Y., Lin, S., Pan, H.-C., Song, P.-J., Raung, S., Lai, C.-Y., Liao, S., Lu, H., & Chen, C. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.01.011 · Cited by 86 · see citing works
Autism Spectrum Disorders and Mastocytosis
Theoharides, T. C. (2009) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200902200401 · Cited by 79 · see citing works
Self-citationThe role of IL-17-secreting mast cells in inflammatory joint disease
Kenna, T., & Brown, M. A. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.205 · Cited by 76 · see citing works
Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder
Napolioni, V., Ober-Reynolds, B., Szelinger, S., Corneveaux, J. J., Pawlowski, T., Ober-Reynolds, S., Kirwan, J., Persico, A. M., Melmed, R. D., Craig, D. W., et al. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-38 · Cited by 76 · see citing works
Neurotensin is increased in serum of young children with autistic disorder
Angelidou, A., Francis, K., Vasiadi, M., Alysandratos, K., Zhang, B., Theoharides, A., Lykouras, L., Sideri, K., Kalogeromitros, D. C., & Theoharides, T. C. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-48 · Cited by 73 · see citing works
Self-citationFranco, J. L., Posser, T., Missau, F. C., Pizzolatti, M. G., Santos, A. R. S., Souza, D. O., Aschner, M., da Rocha, J. B. T., Dafré, A. L., & Farina, M. (2010) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2010.07.003 · Cited by 72 · see citing works
Luteolin inhibits mast cell-mediated allergic inflammation.
Kritas, S. K., Saggini, A., Varvara, G., Murmura, G., Caraffa, A., Antinolfi, P., Toniato, E., Pantalone, A., Neri, G., Frydas, S., et al. (2013) · PubMed · Cited by 65 · see citing works
Self-citationIs a Subtype of Autism an Allergy of the Brain?
Theoharides, T. C. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.04.009 · Cited by 65 · see citing works
Self-citationAngelidou, A., Alysandratos, K., Asadi, S., Zhang, B., Francis, K., Vasiadi, M., Kalogeromitros, D. C., & Theoharides, T. C. (2011) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1171-z · Cited by 64 · see citing works
Self-citationTsilioni, I., Dodman, N. H., Petra, A. I., Taliou, A., Francis, K., Moon-Fanelli, A. A., Shuster, L., & Theoharides, T. C. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.106 · Cited by 63 · see citing works
Self-citationLuteolin inhibits mast cell-mediated allergic inflammation
Kritas, S. K., Saggini, A., Varvara, G., et al. (2013) · International Journal of Immunopathology and Pharmacology · Cited by 60 · see citing works
Theoharides, T. C., Athanassiou, M. C., Panagiotidou, S., & Doyle, R. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.12.003 · Cited by 56 · see citing works
Self-citationBrain cytokines and neuropsychiatric disorders
Theoharides, T. C., Weinkauf, C., & Conti, P. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000148026.86483.4f · Cited by 56 · see citing works
Self-citationDiagnosis and management of autism in childhood
Blenner, S., Reddy, A., & Augustyn, M. C. (2011) · BMJ · doi:10.1136/bmj.d6238 · Cited by 56 · see citing works
Inflammatory Activity in Autism Spectrum Disorder
Tonhajzerová, I., Ondrejka, I., Mestanik, M., Mikolka, P., Hrtánek, I., Mestanikova, A., Bujnakova, I., & Mokrá, D. (2015) · Advances in experimental medicine and biology · doi:10.1007/5584_2015_145 · Cited by 53 · see citing works
Kempuraj, D., Konstantinidou, A. D., BOSCOLO, P., Ferro, F., Giannantonio, M. D., Conti, C. M., Merlitti, D., Petrarca, C., Castellani, M. L., Doyle, R., et al. (2004) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200401700301 · Cited by 52 · see citing works
Self-citationCorticotropin-Releasing Hormone, Microglia and Mental Disorders
Kritas, S. K., Saggini, A., Cerulli, G. G., Caraffa, A., Antinolfi, P., Pantalone, A., Rosati, M., Tei, M. M., Speziali, A., Saggini, R., et al. (2014) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201402700203 · Cited by 45 · see citing works
Luteolin and Thiosalicylate Inhibit HGCL 2 and Thimerosal-Induced VEGF Release from Human Mast Cells
Asadi, S., Zhang, B.-H., Weng, Z., Angelidou, A., Kempuraj, D., Alysandratos, K., & Theoharides, T. C. (2010) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201002300406 · Cited by 40 · see citing works
Self-citationCocchiara, R., Bongiovanni, A., Albeggiani, G., Azzolina, A., & Geraci, D. (1998) · Neuroreport · doi:10.1097/00001756-199801050-00019 · Cited by 26 · see citing works
Toxicity Study of Ethanolic Extract of Chrysanthemum morifolium in Rats
Li, L., Gu, L., Chen, Z., Wang, R., Ye, J., & Jiang, H. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01702.x · Cited by 26 · see citing works
Unwanted Interactions Among Psychotropic Drugs and Other Treatments for Autism Spectrum Disorders
Theoharides, T. C., & Asadi, S. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31825e00e4 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Kandere-Grzybowska K, Kempuraj D, Letourneau L, Asare A, Athanasiou A, Theoharides TC. IL-1 induces differential release of IL-6 form human mast cells. FASEB J 2002; 16: A332.
Cited by
Sorted by citations
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
Rajman, L., Chwalek, K., & Sinclair, D. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.011 · Cited by 865 · see citing works
Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies
Aziz, N., Kim, M., & Cho, J. Y. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.05.019 · Cited by 654 · see citing works
Feeding the microbiota–gut–brain axis: Diet, microbiome, and neuropsychiatry
Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Translational Research · doi:10.1016/j.trsl.2016.10.002 · Cited by 491 · see citing works
The influence of neuroinflammation in Autism Spectrum Disorder
Matta, S. M., Hill‐Yardin, E. L., & Crack, P. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.037 · Cited by 414 · see citing works
Neuroinflammation and Oxidative Stress in the Pathogenesis of Autism Spectrum Disorder
Usui, N., Kobayashi, H., & Shimada, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065487 · Cited by 267 · see citing works
Saghazadeh, A., Ataeinia, B., Keynejad, K., Abdolalizadeh, A., Hirbod‐Mobarakeh, A., & Rezaei, N. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.019 · Cited by 239 · see citing works
Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders
Theoharides, T. C., Tsilioni, I., Patel, A., & Doyle, R. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.77 · Cited by 231 · see citing works
Self-citationLong‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue
Theoharides, T. C., Cholevas, C., Polyzoidis, K. S., & Politis, A. M. (2021) · BioFactors · doi:10.1002/biof.1726 · Cited by 219 · see citing works
Self-citationRole of diet and its effects on the gut microbiome in the pathophysiology of mental disorders
Horn, J., Mayer, D. E., Chen, S., & Mayer, E. A. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01922-0 · Cited by 193 · see citing works
Zawadzka, A., Cieślik, M., & Adamczyk, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111516 · Cited by 190 · see citing works
Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration
Molina-Gonzalez, I., Holloway, R. K., Jiwaji, Z., Dando, O., Kent, S. A., Emelianova, K., Lloyd, A. F., Forbes, L. H., Mahmood, A., Skripuletz, T., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39046-8 · Cited by 176 · see citing works
“The established safety pro fi le ofLuteolininhumans 51 – 53 anditsavailabilityasadietarysupplement 51,53 highlight it asa promising regenerative therapy, in addition to drugs in clinical trial which directly impact the oligodendrocyte lineage 48,54 – 56 .”
The microbiota, immunoregulation, and mental health: implications for public health
Lowry, C. A., Smith, D. G., Siebler, P. H., Schmidt, D., Stamper, C. E., Hassell, J. E., Yamashita, P. S., Fox, J. H., Reber, S. O., Brenner, L. A., et al. (2016) · Current Environmental Health Reports · doi:10.1007/s40572-016-0100-5 · Cited by 172 · see citing works
Antiviral activity of luteolin against Japanese encephalitis virus
Fan, W., Qian, S., Qian, P., & Li, X. (2016) · Virus Research · doi:10.1016/j.virusres.2016.04.021 · Cited by 168 · see citing works
Wang, Z., Zeng, M., Wang, Z., Qin, F., Chen, J., & He, Z. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c08085 · Cited by 162 · see citing works
Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome?
Theoharides, T. C. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02696-0 · Cited by 154 · see citing works
Self-citationPolyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?
Mamun, A. A., Shao, C., Geng, P., Wang, S., & Xiao, J. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.90982 · Cited by 134 · see citing works
Immune Abnormalities in Autism Spectrum Disorder—Could They Hold Promise for Causative Treatment?
Gładysz, D., Krzywdzińska, A., & Hozyasz, K. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0822-x · Cited by 130 · see citing works
Theoharides, T. C., Tsilioni, I., & Ren, H. L. (2019) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2019.1596800 · Cited by 124 · see citing works
Self-citationPatel, A., Tsilioni, I., Leeman, S. E., & Theoharides, T. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604992113 · Cited by 121 · see citing works
Self-citationThe path toward using microbial metabolites as therapies
Descamps, H. C., Herrmann, B. I., Wiredu, D., & Thaiss, C. A. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.05.063 · Cited by 121 · see citing works
Niu, W., Wu, F., Cao, W.-Y., Wu, Z., Chao, Y.-C., Peng, F., & Liang, C. (2020) · Bioscience Reports · doi:10.1042/bsr20202583 · Cited by 111 · see citing works
Association of Peripheral Blood Levels of Cytokines With Autism Spectrum Disorder: A Meta-Analysis
Zhao, H., Zhang, H., Liu, S., Luo, W., Jiang, Y., & Gao, J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.670200 · Cited by 111 · see citing works
Yang, S., Chen, P., Chang, S.-H., Weng, Y., Chang, F., Chang, K.-Y., Chen, C.-Y., Kao, T., & Hwang, T. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.06.003 · Cited by 106 · see citing works
mTOR Signaling Disruption and Its Association with the Development of Autism Spectrum Disorder
Thomas, S. D., Jha, N. K., Ojha, S. K., & Sadek, B. S. (2023) · Molecules · doi:10.3390/molecules28041889 · Cited by 100 · see citing works
Tartaglione, A. M., Villani, A., Ajmone‐Cat, M. A., Minghetti, L., Ricceri, L., Pazienza, V., Simone, R. D., & Calamandrei, G. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02149-9 · Cited by 94 · see citing works
Das, S., Pahari, S., Sarmah, S., Rohman, M. A., Paul, D., Jana, M., & Roy, A. S. (2019) · Physical Chemistry Chemical Physics · doi:10.1039/c9cp01128e · Cited by 86 · see citing works
Luteolin: A promising natural agent in management of pain in chronic conditions
Ntalouka, F., & Tsirivakou, A. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1114428 · Cited by 84 · see citing works
Cytokine profile in autistic patients
Eftekharian, M. M., Ghafouri‐Fard, S., Noroozi, R., Omrani, M. D., Arsang‐Jang, S., Ganji, M., Gharzi, V., Noroozi, H., Komaki, A., Mazdeh, M., et al. (2018) · Cytokine · doi:10.1016/j.cyto.2018.03.034 · Cited by 82 · see citing works
Bioavailability and Pharmaco-therapeutic Potential of Luteolin in Overcoming Alzheimer’s Disease
Ali, F. R., & Siddique, Y. H. (2019) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527318666190319141835 · Cited by 82 · see citing works
Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum Disorders?
Pangrazzi, L., Balasco, L., & Bozzi, Y. (2020) · Antioxidants · doi:10.3390/antiox9121186 · Cited by 75 · see citing works
Nadeem, A., Ahmad, S. F., Al-Harbi, N. O., AL-Ayadhi, L. Y., Sarawi, W. S., Attia, S. M., Bakheet, S. A., Alqarni, S. A., Ali, N., & AsSobeai, H. M. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.12.009 · Cited by 75 · see citing works
Microglia mediated neuroinflammation in autism spectrum disorder
Liao, X., Yang, J., Wang, H., & Li, Y. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.07.013 · Cited by 74 · see citing works
Nadeem, A., Ahmad, S. F., Attia, S. M., AL-Ayadhi, L. Y., Al-Harbi, N. O., & Bakheet, S. A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109783 · Cited by 72 · see citing works
Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy
Marchezan, J., Winkler dos Santos, E. G. A., Deckmann, I., & Riesgo, R. D. S. (2018) · Neuroimmunomodulation · doi:10.1159/000492225 · Cited by 70 · see citing works
Luteolin for neurodegenerative diseases: a review
Jayawickreme, K., Ekwosi, C., Anand, A., Andres‐Mach, M., Właź, P., & Socała, K. (2024) · Pharmacological Reports · doi:10.1007/s43440-024-00610-8 · Cited by 68 · see citing works
Nadeem, A., Ahmad, S. F., Attia, S. M., AL-Ayadhi, L. Y., Bakheet, S. A., & Al-Harbi, N. O. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.12.002 · Cited by 63 · see citing works
NAD+ in COVID-19 and viral infections
Zheng, M., Schultz, M. B., & Sinclair, D. A. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.02.001 · Cited by 62 · see citing works
Hatziagelaki, E., Adamaki, M., Tsilioni, I., Dimitriadis, G., & Theoharides, T. C. (2018) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.250845 · Cited by 62 · see citing works
Self-citationElmazoğlu, Z., Sağlam, A. S. Y., Sonmez, C., & Karasu, Ç. (2018) · Drug and Chemical Toxicology · doi:10.1080/01480545.2018.1504961 · Cited by 62 · see citing works
Juszczak, A. M., Wölfle, U., Končić, M. Z., & Tomczyk, M. (2022) · Medicinal Research Reviews · doi:10.1002/med.21880 · Cited by 61 · see citing works
Role of dietary phenols in mitigating microglia-mediated neuroinflammation
Rangarajan, P., Karthikeyan, A., & Dheen, S. T. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8430-x · Cited by 61 · see citing works
Tsilioni, I., Patel, A., Pantazopoulos, H., Berretta, S., Conti, P., Leeman, S. E., & Theoharides, T. C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906817116 · Cited by 61 · see citing works
Self-citationSarmah, S., Pahari, S., Belwal, V. K., Jana, M., & Roy, A. S. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.114147 · Cited by 59 · see citing works
Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS‐CoV ‐2
Gour, A., Manhas, D., Bag, S., Gorain, B., & Nandi, U. (2021) · Phytotherapy Research · doi:10.1002/ptr.7092 · Cited by 57 · see citing works
Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?
Palaniyappan, L. K., Park, M. T. M., Jeon, P., Limongi, R., Yang, K., Sawa, A., & Théberge, J. (2021) · Antioxidants · doi:10.3390/antiox10111703 · Cited by 57 · see citing works
Therapeutic Opportunities of Interleukin-33 in the Central Nervous System
Sun, Y. T., Wen, Y., Wang, L., Wen, L., You, W., Wei, S., Mao, L., Wang, H., Chen, Z., & Yang, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.654626 · Cited by 55 · see citing works
Mast Cells, Stress, Fear and Autism Spectrum Disorder
Theoharides, T. C., Kavalioti, M., & Tsilioni, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153611 · Cited by 55 · see citing works
Self-citationThe psychopharmacology of autism spectrum disorder and Rett syndrome
Persico, A. M., Ricciardello, A., & Cucinotta, F. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64012-3.00024-1 · Cited by 53 · see citing works
Gelabert-Rebato, M., Wiebe, J. C., Martin-Rincon, M., Galvan-Alvarez, V., Curtelin, D., Perez-Valera, M., Juan Habib, J., Pérez-López, A., Vega, T., Morales-Alamo, D., et al. (2019) · Nutrients · doi:10.3390/nu11020344 · Cited by 49 · see citing works
Tomarken, A. J., Han, G. T., & Corbett, B. A. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.08.016 · Cited by 49 · see citing works
Pistollato, F., Forbes-Hernández, T. Y., Iglesias, R. C., Ruíz, R., Elexpuru-Zabaleta, M., Cianciosi, D., Giampieri, F., & Battino, M. A. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104579 · Cited by 48 · see citing works
A pilot dose finding study of pioglitazone in autistic children
Capano, L., Dupuis, A., Brian, J. A., Mankad, D., Genore, L., Adams, R. H., Smile, S., Lui, T., Odrobina, D., Foster, J. A., et al. (2018) · Molecular Autism · doi:10.1186/s13229-018-0241-5 · Cited by 47 · see citing works
Review of Clinical Studies Targeting Inflammatory Pathways for Individuals With Autism
Hafizi, S., Tabatabaei, D., & Lai, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00849 · Cited by 47 · see citing works
The Contribution of Inflammation to Autism Spectrum Disorders: Recent Clinical Evidence
Prata, J., Machado, A. S., von Doellinger, O., Almeida, M. I., Barbosa, M. A., Coelho, R. C., & Santos, S. G. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9554-7_29 · Cited by 46 · see citing works
Polyphenols in the management of brain disorders: Modulation of the microbiota-gut-brain axis
Serra, D., Almeida, L. M., & Dinis, T. C. P. (2019) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2019.08.001 · Cited by 46 · see citing works
Neuroinflammation in Alzheimer's disease and beneficial action of luteolin
Delgado, A., Cholevas, C., & Theoharides, T. C. (2021) · BioFactors · doi:10.1002/biof.1714 · Cited by 46 · see citing works
Self-citationSingh, R., Kisku, A., Kungumaraj, H. J., Nagaraj, V., Pal, A., Kumar, S., & Sulakhiya, K. (2023) · Biomedicines · doi:10.3390/biomedicines11010115 · Cited by 45 · see citing works
Pioglitazone abolishes autistic-like behaviors via the IL-6 pathway
Kirsten, T. B., Casarin, R. C. V., Bernardi, M. M., & Felício, L. F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197060 · Cited by 44 · see citing works
Schomberg, J., Wang, Z., Farhat, A. M., Guo, K. L., Xie, J., Zhou, Z., Liu, J., Kovacs, B., & Liu, F. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114025 · Cited by 44 · see citing works
Hadrich, F., Chamkha, M., & Sayadi, S. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112752 · Cited by 43 · see citing works
Wang, X., Hu, R., Lin, F. H., Yang, T., Lu, Y., Sun, Z., Li, T., & Chen, J. (2024) · Food Research International · doi:10.1016/j.foodres.2024.115212 · Cited by 42 · see citing works
Microglial contribution to the pathology of neurodevelopmental disorders in humans
Matulevičiūtė, R., Akinluyi, E. T., Muntslag, T. A. O., Dewing, J. M., Long, K. R., Vernon, A. C., Tremblay, M., & Menassa, D. A. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02629-2 · Cited by 41 · see citing works
Targeting STATs in neuroinflammation: The road less traveled!
Nabavi, S. M., Ahmed, T., Nawaz, M., Devi, K. P., Balan, D. J., Pittalà, V., Argüelles, S., Testai, L., Khan, H. Z., Sureda, A., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.12.004 · Cited by 41 · see citing works
Tsilioni, I., Pantazopoulos, H., Conti, P., Leeman, S. E., & Theoharides, T. C. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004666117 · Cited by 41 · see citing works
Self-citationNaia, L., Pinho, C. M., Dentoni, G., Liu, J., Leal, N. S., Ferreira, D. M. S., Schreiner, B., Filadi, R., Fão, L., Connolly, N. M. C., et al. (2021) · BMC Biology · doi:10.1186/s12915-021-00979-5 · Cited by 40 · see citing works
Asgharian, P., Quispe, C., Herrera‐Bravo, J., Sabernavaei, M., Hosseini, K., Forouhandeh, H., Ebrahimi, T., Sharafi-Badr, P., Tarhriz, V., Soofiyani, S. R., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.926607 · Cited by 39 · see citing works
Tiwari, P., & Mishra, K. P. (2019) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1694193 · Cited by 39 · see citing works
Medina, M. A., Andrade, V., Caracci, M. O., Ávila, M. E., Verdugo, D. A., Vargas, M. F., Ugarte, G. D., Reyes, A. E., Opazo, C., & Ferrari, G. V. D. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0093-y · Cited by 38 · see citing works
The use of iPSC technology for modeling Autism Spectrum Disorders
Russo, F. B., Brito, A., de Freitas, A. M., Castanha, A. G., Freitas, B. C. D., & Beltrão-Braga, P. C. B. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104483 · Cited by 38 · see citing works
Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey
Kütük, M. Ö., Tufan, A. E., Gökçen, C., Kılıçaslan, F., Karadağ, M., Mutluer, T., Yektaş, Ç., Coban, N., Kandemır, H., Büber, A., et al. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155152 · Cited by 38 · see citing works
Mazahery, H., Conlon, C. A., Beck, K. L., Mugridge, O., Kruger, M. C., Stonehouse, W., Camargo, C. A., Meyer, B. J., Tsang, B., & von Hurst, P. R. (2020) · Nutrients · doi:10.3390/nu12030661 · Cited by 37 · see citing works
Nuclear Factor Kappa B in Autism Spectrum Disorder: A Systematic Review
Liao, X., & Li, Y. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104918 · Cited by 37 · see citing works
Li, H., Liu, H., Chen, X., Zhang, J., Tong, G., & Sun, Y. (2020) · European Journal of Pediatrics · doi:10.1007/s00431-020-03826-x · Cited by 37 · see citing works
Medical Therapies for Children With Autism Spectrum Disorder—An Update
Edwin Williamson, M. D., Sathe, N. A., & Andrews, J. C. (2017) · doi:10.23970/ahrqepccer189 · Cited by 37 · see citing works
Wang, B., Qin, Y., Wu, Q., Li, X., Xie, D., Zhao, Z., & Duan, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.818518 · Cited by 36 · see citing works
The Emerging Role of Flavonoids in Autism Spectrum Disorder: A Systematic Review
Savino, R., Medoro, A., Alì, S., Scapagnini, G., Maes, M. H. J., & Davinelli, S. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12103520 · Cited by 35 · see citing works
Exploring Dietary Interventions in Autism Spectrum Disorder
Pérez-Cabral, I. D., Bernal-Mercado, A. T., Islas-Rubio, A. R., Suárez-Jiménez, G. M., Robles-García, M. Á., Puebla-Duarte, A. L., & Del‐Toro‐Sánchez, C. L. (2024) · Foods · doi:10.3390/foods13183010 · Cited by 35 · see citing works
Ross, F. C., Mayer, D. E., Gupta, A., Gill, C. I. R., Rio, D. D., Cryan, J. F., Lavelle, A., Ross, R. P., Stanton, C., & Mayer, E. A. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.10.018 · Cited by 35 · see citing works
Modeling Inflammation in Autism Spectrum Disorders Using Stem Cells
Freitas, B., Mei, A., Mendes, A. P. D., Beltrão-Braga, P. C. B., & Marchetto, M. C. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00394 · Cited by 34 · see citing works
Dietary interventions for autism spectrum disorder: An updated systematic review of human studies
Amadi, C. N., Orish, C. N., Frazzoli, C., & Orisakwe, O. E. (2022) · Psychiatriki · doi:10.22365/jpsych.2022.073 · Cited by 34 · see citing works
Gelabert-Rebato, M., Wiebe, J. C., Martin-Rincon, M., Gericke, N., Perez-Valera, M., Curtelin, D., Galvan-Alvarez, V., Lopez-Rios, L., Morales-Alamo, D., & Calbet, J. A. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00740 · Cited by 33 · see citing works
Repurposing SGLT2 Inhibitors for Neurological Disorders: A Focus on the Autism Spectrum Disorder
Nakhal, M. M., Aburuz, S., Sadek, B. S., & Akour, A. A. (2022) · Molecules · doi:10.3390/molecules27217174 · Cited by 32 · see citing works
Antioxidant and Anti-Inflammatory Properties of Phytochemicals Found in the Yucca Genus
Bahena-Culhuac, E., Maggiolino, A., Elghandour, M. M. M. Y., Palo, P. D., & Salem, A. Z. M. (2023) · Antioxidants · doi:10.3390/antiox12030574 · Cited by 32 · see citing works
Che, X., Hornig, M., Bresnahan, M., Stoltenberg, C., Magnus, P. M., Surén, P., Mjaaland, S., Reichborn-Kjennerud, T., Susser, E., & Lipkin, W. I. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01415-4 · Cited by 32 · see citing works
Serra, D., Almeida, L. M., & Dinis, T. C. P. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.010 · Cited by 31 · see citing works
A Luteolin-Loaded Electrospun Fibrous Implantable Device for Potential Therapy of Gout Attacks
Wang, Y., Luo, C., Yang, G., Wei, X., Liu, D., & Zhou, S. (2016) · Macromolecular Bioscience · doi:10.1002/mabi.201600123 · Cited by 30 · see citing works
Khoshnan, A., Sabbaugh, A., Calamini, B., Marinero, S., Dunn, D., Yoo, J. H., Ko, J., Lo, D. C., & Patterson, P. H. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx315 · Cited by 30 · see citing works
Microglia as possible therapeutic targets for autism spectrum disorders
Andoh, M., Ikegaya, Y., & Koyama, R. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.06.012 · Cited by 30 · see citing works
Theoharides, T. C. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11090860 · Cited by 29 · see citing works
Self-citationTassinari, M., Mottolese, N., Galvani, G., Ferrara, D., Gennaccaro, L., Loi, M., Medici, G., Candini, G., Rimondini, R., Ciani, E., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158719 · Cited by 29 · see citing works
Alzghoul, L., Abdelhamid, S. S., Yanis, A., Qwaider, Y. Z., Aldahabi, M., & Albdour, S. (2019) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1812-167 · Cited by 29 · see citing works
Yazar, M., Sevindik, М., Polat, A. O., Koçer, O., KARATEPE, H. K., & Uysal, İ. (2024) · Prospects in Pharmaceutical Sciences · doi:10.56782/pps.286 · Cited by 27 · see citing works
Autism Associated With Anti-NMDAR Encephalitis: Glutamate-Related Therapy
Tzang, R., Chang, C., Chang, Y., & Lane, H. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00440 · Cited by 27 · see citing works
Miao, L., Liu, C., Cheong, M. S., Zhong, R., Tan, Y., Rengasamy, K. R. R., Leung, S. W. S., Cheang, W. S., & Xiao, J. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2095349 · Cited by 27 · see citing works
Increased Expression of miR‐155p5 in Amygdala of Children With Autism Spectrum Disorder
Almehmadi, K., Tsilioni, I., & Theoharides, T. C. (2019) · Autism Research · doi:10.1002/aur.2205 · Cited by 26 · see citing works
Self-citationAre there early inflammatory biomarkers that affect neurodevelopment in infancy?
Voltas, N., Arija, V., Hernández‐Martínez, C., Jiménez‐Feijoo, R., Ferré, N., & Canals, J. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.01.017 · Cited by 23 · see citing works
Akhtar, A., & Rahaman, S. B. (2025) · Brain Sciences · doi:10.3390/brainsci15080853 · Cited by 21 · see citing works
Cathepsin B inhibition ameliorates leukocyte‐endothelial adhesion in the BTBR mouse model of autism
Wang, H., Yin, Y., Gong, D., Hong, L., Wu, G., Jiang, Q., Wang, C., Blinder, P., Long, S., Han, F., et al. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13074 · Cited by 20 · see citing works
Do Alarmins Have a Potential Role in Autism Spectrum Disorders Pathogenesis and Progression?
Salvo, E. D., Casciaro, M., Quartuccio, S., Genovese, L., & Gangemi, S. (2018) · Biomolecules · doi:10.3390/biom9010002 · Cited by 20 · see citing works
Shehnaz, S. I., Roy, A., Vijayaraghavan, R., & Sivanesan, S. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04544-4 · Cited by 19 · see citing works
- Authors
- Tsilioni, I., Taliou, A., Francis, K., & Theoharides, T. C.
- Affiliations
- Tufts University (US)
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Theoharides, T C
- Venue
- Translational Psychiatry
- Published
- 2015-09-29
- Volume
- 5
- Issue
- 9
- Pages
- e647-e647
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC5545641
- OpenAlex
- W2207328331
- Cited by
- 199
- References
- 87
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 24 · 2023: 24 · 2022: 21 · 2021: 24 · 2020: 20 · 2019: 23 · 2018: 19 · 2017: 4 · 2016: 10 · 2015: 1
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Translational Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Brenen Hornstein Autism Research & Education Foundation
- Autism Research Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, luteolin, diet formulation, interleukin-6, TNF-α, serum cytokines, corticotropin-releasing factor, neurotensin, neuroinflammation, microglial activation, prognostic factors, children
- MeSH terms
- Autism Spectrum Disorder, Behavioral Symptoms, Child, Child, Preschool, Corticotropin-Releasing Hormone, Diet Therapy, Female, Food, Formulated, Humans, Inflammation, Male, Neurotensin, Prognosis, Tumor Necrosis Factor-alpha, Reproducibility of Results, Interleukin-6, Treatment Outcome, Diagnostic and Statistical Manual of Mental Disorders, Luteolin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review