The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mammalian Deoxyribonucleic Acid-dependent Ribonucleic Acid Polymerases
Open accessAbstract
Abstract A procedure is described for the purification of DNA-dependent RNA polymerase II of the human tissue culture cell lines HeLa and KB. The enzyme has a molecular weight of approximately 500,000 and in sodium dodecyl sulfate polyacrylamide gels invariably shows 3 subunits with molecular weights of 220,000, 140,000, and 35,000. In addition there perhaps is a fourth subunit of about 25,000 daltons or less in mass and a subunit of 170,000 daltons occurring in variable amounts. RNA polymerase II has a strong preference for single-stranded over double-stranded DNA as template and is most active in the presence of 1.5 to 3 mm Mn++ as divalent cation. We also describe the partial purification of two stimulatory factors (SF-A and SF-B) which specifically stimulate the activity of RNA polymerase II in the presence of double-stranded DNA as template.
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Citations
Cites
Amino acid metabolism in Mammalian cell cultures
Eagle, H. (1959) · Science · doi:10.1126/science.130.3373.432 · Cited by 4,011
Degradation of DNA RNA Hybrids by Ribonuclease H and DNA Polymerases of Cellular and Viral Origin
Keller, W., & Crouch, R. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.11.3360 · Cited by 222
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Metadata
- Authors
- Sugden, B., & Keller, W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1973-06
- Volume
- 248
- Issue
- 11
- Pages
- 3777-3788
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1499988740
- Cited by
- 158
- References
- 2
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sugden, B., & Keller, W. (1973). Mammalian Deoxyribonucleic Acid-dependent Ribonucleic Acid Polymerases. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)43802-7
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