Amino acid metabolism in Mammalian cell cultures
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Basal media such as DMEM, F-12, or DMEM/F-12 combinations are inherently xeno-free, protein-free, and chemically defined.
“Basal media such as Dulbecco’s Modified Eagle Medium (DMEM), Ham’s F-12 (F-12), or DMEM/F-12 combinations are inherently xeno-free, protein-free, and chemically defined (Eagle, 1959; Ham, 1965).”
From Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays (2026) · cites this paper as Eagle, 1959
Cites
The growth response of mammalian cells in tissue culture to L-glutamine and L-glutamic acid
Eagle, H., Oyama, V. I., Levy, M., Horton, C. L., & Fleischman, R. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65826-0 · Cited by 354 · see citing works
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The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works
Cao, J. Y., & Dixon, S. J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2194-1 · Cited by 1,515 · see citing works
Established eurythermic line of fish cells in vitro
Wolf, K., & Quimby, M. C. (1962) · Science · doi:10.1126/science.135.3508.1065 · Cited by 638 · see citing works
Edmonds, M., Vaughan, M. H., & Nakazato, H. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.6.1336 · Cited by 510 · see citing works
Morphologic changes accompanying senescence of cultured human diploid cells
Robbins, E., Levine, E. M., & Eagle, H. (1970) · The Journal of Experimental Medicine · doi:10.1084/jem.131.6.1211 · Cited by 247 · see citing works
Self-citationPOLIOVIRUS-INDUCED RNA POLYMERASE AND THE EFFECTS OF VIRUS-SPECIFIC INHIBITORS ON ITS PRODUCTION
Baltimore, D., Eggers, H. J., Franklin, R. M., & Tamm, I. (1963) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.49.6.843 · Cited by 228 · see citing works
RNA polymerase activity in purified infectious vaccinia virus.
Munyon, W., Paoletti, E., & Grace, J. T. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.58.6.2280 · Cited by 211 · see citing works
Animal tissue culture principles and applications
Verma, A., Verma, M., & Singh, A. (2020) · Animal Biotechnology · doi:10.1016/b978-0-12-811710-1.00012-4 · Cited by 161 · see citing works
“Eagle (1959) developed a “minimal essential medium” composed of balanced salts, glucose, amino acids, and vitamins.”
Virus-Specific Double-Stranded RNA in Poliovirus-Infected Cells
Baltimore, D., Becker, Y., & Darnell, J. E. (1964) · Science · doi:10.1126/science.143.3610.1034 · Cited by 130 · see citing works
Structure of the poliovirus replicative intermediate RNA
Baltimore, D. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90015-6 · Cited by 123 · see citing works
Berns, K. I., & Adler, S. (1972) · Journal of Virology · doi:10.1128/jvi.9.2.394-396.1972 · Cited by 101 · see citing works
Cohen, E. P., & Eagle, H. (1961) · The Journal of Experimental Medicine · doi:10.1084/jem.113.2.467 · Cited by 59 · see citing works
Self-citationMITOCHONDRIAL PROTEIN SYNTHESIS IN H<scp>E</scp>L<scp>A</scp> CELLS
Galper, J. B. (1974) · The Journal of Cell Biology · doi:10.1083/jcb.60.3.755 · Cited by 23 · see citing works
Spänle, J. V., Haiber, L. M., & Seeger, B. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1800157 · Cited by 1 · see citing works
- Authors
- Eagle, H.
- Affiliations
- Chief of the laboratory of cell biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
- Venue
- Science
- Published
- 1959-08-21
- Volume
- 130
- Issue
- 3373
- Pages
- 432-437
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 3,079
- References
- 1
- Language
- en
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