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Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin, an inhibitor of processing glucosidases
Open accessAbstract
H3G I Y6Glucosidase activities which remove glucose residues from GlcZMangGlcNAcz and GlclManyGlcNAcz oligosaccharides were obtained in soluble form from Saccharomyces cerevisiae X-2180 without detergent.These two enzyme activities were clearly separated from the GlcsMangGlcNAcz oligosaccharide glucosidase which was shown previously to remove the terminal glucose residue from GlcsMan9GlcNAcz oligosaccharide (Kilker,
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“GII inhibitors include the pyranose sugar analogues 1-deoxynojirimycin, N-5-carboxypentyl-dNM, and castanospermine, all iminosugars [218,376,377].”
From GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review (2022) · cites this paper as [377]
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“Regarding interactions, unlike the UGGT that does not have an identified inhibitor (apart from its product, UDP) [319], GII inhibitors include the pyranose sugar analogues 1-deoxynojirimycin, N-5-carboxypentyl-dNM, and castanospermine, all iminosugars [218,376,377].”
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Metadata
- Authors
- Saunier, B., Kilker, R. D., Tkacz, J. S., Quaroni, A., & Herscovics, A.
- Affiliations
- Harvard University (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1982-12
- Volume
- 257
- Issue
- 23
- Pages
- 14155-14161
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1515555384
- Cited by
- 283
- References
- 26
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 1 · 2019: 3 · 2018: 7 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- 1-deoxynojirimycin, glucosidase inhibitors, Saccharomyces cerevisiae, oligosaccharide processing
- MeSH terms
- Glucosamine, Glucosidases, Glycoproteins, Kinetics, Oligosaccharides, Saccharomyces cerevisiae, Sucrase, 1-Deoxynojirimycin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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