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Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin, an inhibitor of processing glucosidases
Open accessAbstract
H3G I Y6Glucosidase activities which remove glucose residues from GlcZMangGlcNAcz and GlclManyGlcNAcz oligosaccharides were obtained in soluble form from Saccharomyces cerevisiae X-2180 without detergent.These two enzyme activities were clearly separated from the GlcsMangGlcNAcz oligosaccharide glucosidase which was shown previously to remove the terminal glucose residue from GlcsMan9GlcNAcz oligosaccharide (Kilker,
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“GII inhibitors include the pyranose sugar analogues 1-deoxynojirimycin, N-5-carboxypentyl-dNM, and castanospermine, all iminosugars [218,376,377].”
From GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review (2022) · cites this paper as [377]
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Metadata
- Authors
- Saunier, B., Kilker, R. D., Tkacz, J. S., Quaroni, A., & Herscovics, A.
- Affiliations
- Harvard University (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1982-12
- Volume
- 257
- Issue
- 23
- Pages
- 14155-14161
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1515555384
- Cited by
- 283
- References
- 26
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 1 · 2019: 3 · 2018: 7 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- 1-deoxynojirimycin, glucosidase inhibitors, Saccharomyces cerevisiae, oligosaccharide processing
- MeSH terms
- Glucosamine, Glucosidases, Glycoproteins, Kinetics, Oligosaccharides, Saccharomyces cerevisiae, Sucrase, 1-Deoxynojirimycin
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