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A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II.
Open accessAbstract
Two monoclonal antibodies produced by hybridomas obtained from a mouse immunized with a colorectal carcinoma cell line bind specifically to human gastrointestinal cancer cells. The antigen of this antibody in the carcinoma cell line, a monosialoganglioside, has been isolated. Its carbohydrate structure is probably (formula: see text). This oligosaccharide is a sialyl derivative of lacto-N-fucopentaose II, a hapten of the human Lea blood group antigen. About 30 micrograms of ganglioside is obtained from 1 g of cells, wet weight. The ganglioside was detected by autoradiography in lipid extracts of some carcinomas and of meconium, but not in lipid extracts of normal adult tissues. Antigen was detected by solid phase radioimmunoassay in lipid extracts from 12 out of 21 adenocarcinomas of the colon, from 4 out of 5 gastric adenocarcinomas, and from 4 out of 7 pancreatic carcinomas. Antigen was not detected in lipid extracts from 5 esophageal carcinomas or from normal colon and gastric mucosa, pancreas, kidney, liver, and bone marrow.
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Citations
Cited by
Glycosylation in health and disease
Reily, C., Stewart, T. J., Renfrow, M. B., & Novak, J. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0129-4 · Cited by 2,075
The repertoire of glycan determinants in the human glycome
Cummings, R. D. (2009) · Molecular BioSystems · doi:10.1039/b907931a · Cited by 487
Berg, E. L., Robinson, M. K., Mansson, O., Butcher, E. C., & Magnani, J. L. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98555-8 · Cited by 473
Self-citationBerger, A. C., Garcia, M., Hoffman, J. P., Regine, W. F., Abrams, R. A., Safran, H., Konski, A., Benson, A. B., MacDonald, J., & Willett, C. G. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.6288 · Cited by 371
Involvement of Sialic Acid on Endothelial Cells in Organ-Specific Lymphocyte Recirculation
Rosen, S. D., Singer, M. S., Yednock, T. A., & Stoolman, L. M. (1985) · Science · doi:10.1126/science.4001928 · Cited by 235
Metadata
- Authors
- Magnani, J. L., Nilsson, B., Brockhaus, M., Zopf, D., Steplewski, Z., Koprowski, H., & Ginsburg, V
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1982-12
- Volume
- 257
- Issue
- 23
- Pages
- 14365-14369
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1754937767
- Cited by
- 881
- References
- 0
- FWCI
- 20.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. https://app.cochat.ai/papers/10.1016/s0021-9258(19)45389-1
- The paper
- Magnani, J. L., Nilsson, B., Brockhaus, M., Zopf, D., Steplewski, Z., Koprowski, H., & Ginsburg, V. (1982). A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)45389-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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