Involvement of Sialic Acid on Endothelial Cells in Organ-Specific Lymphocyte Recirculation

Rosen, Steven D.; Singer, Mark S.; Yednock, Ted A.; Stoolman, Lloyd M.

doi:10.1126/science.4001928

Cited by 235Cell Adhesion Molecules ResearchGlycosylation and Glycoproteins ResearchT-cell and B-cell Immunology

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Involvement of Sialic Acid on Endothelial Cells in Organ-Specific Lymphocyte Recirculation

Rosen, Steven D., Singer, Mark S., Yednock, Ted A., Stoolman, Lloyd M.·1985·Science

DOI 10.1126/science.4001928

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Abstract

Mouse lymphocytes incubated on cryostat-cut sections of lymphoid organs (lymph nodes and Peyer's patches) specifically adhere to the endothelium of high endothelial venules (HEV), the specialized blood vessels to which recirculating lymphocytes attach as they migrate from the blood into the parenchyma of the lymphoid organs. Treatment of sections with sialidase eliminated the binding of lymphocytes to peripheral lymph node HEV, had no effect on binding to Peyer's patch HEV, and had an intermediate effect on mesenteric lymph node HEV. These results suggest that sialic acid on endothelial cells may be an organ-specific recognition determinant for lymphocyte attachment.

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Authors: Rosen, S. D., Singer, M. S., Yednock, T. A., & Stoolman, L. M.
Affiliations: University of California, San Francisco (US)
University of Michigan (US)
ORCID: Rosen, Steven D.
Yednock, Ted A.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1985-05-24
Volume: 228
Issue: 4702
Pages: 1005-1007
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.4001928
OpenAlex: W1985157666
Cited by: 235
References: 19
Citations by year: 2025: 1 · 2023: 1 · 2020: 3 · 2019: 3 · 2018: 4 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 2
FWCI: 8.39
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2k08ca000959-04)
National Cancer Institute (1K08CA00959)
National Institute of General Medical Sciences (GM235472)
Topics: Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: sialic acid, endothelial cells, high endothelial venules, lymphocyte recirculation, lymphocyte adhesion, neuraminidase, lymph nodes, Peyer's patches, lymphocyte homing, lymphoid organs
MeSH terms: Animals, Cell Adhesion, Endothelium, Lymph Nodes, Lymphocytes, Neuraminidase, Organ Specificity, Peyer's Patches, Sialic Acids, Venules, Mice

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Involvement of Sialic Acid on Endothelial Cells in Organ-Specific Lymphocyte Recirculation

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