The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors.
Open accessAbstract
The Ca(2+)-dependent K+ channel of human red cells was inhibited with high affinity by several imidazole antimycotics which are potent inhibitors of cytochrome P-450. IC50 values were (in microM): clotrimazole, 0.05; tioconazole, 0.3; miconazole, 1.5; econazole, 1.8. Inhibition of the channel was also found with other drugs with known cytochrome P-450 inhibitory effect. However, no inhibition was obtained with carbon monoxide (CO). This suggests that, given the high selectivity of the above inhibitors for the heme moiety, a different but closely related to cytochrome P-450 kind of hemoprotein may be involved in the regulation of the red cell Ca(2+)-dependent K+ channel. Clotrimazole also inhibited two other charybdotoxin-sensitive Ca(2+)-dependent K+ channels, those of rat thymocytes (IC50 = 0.1-0.2 microM) and of Ehrlich ascites tumor cells (IC50 = 0.5 microM). Imidazole antimycotics inhibit also receptor-operated Ca2+ channels (Montero, M., Alvarez, J. and García-Sancho, J. (1991) Biochem. J. 277, 73-79). This suggests that both Ca2+ and Ca(2+)-dependent K+ channels might have a similar regulatory mechanism involving a cytochrome.
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UBIQUITIN-DEPENDENT PROTEIN DEGRADATION
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Metadata
- Authors
- Alvarez, J., Montero, M., & Garcia-Sancho, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-06
- Volume
- 267
- Issue
- 17
- Pages
- 11789-11793
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1601900247
- Cited by
- 281
- References
- 39
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Alvarez, J., Montero, M., & Garcia-Sancho, J. (1992). High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)49767-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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