The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
Abstract
The E6 protein encoded by the oncogenic human papillomavirus types 16 and 18 is one of two viral products expressed in HPV-associated cancers. E6 is an oncoprotein which cooperates with E7 to immortalize primary human keratinocytes. Insight into the mechanism by which E6 functions in oncogenesis is provided by the observation that the E6 protein encoded by HPV-16 and HPV-18 can complex the wild-type p53 protein in vitro. Wild-type p53 gene has tumor suppressor properties, and is a target for several of the oncoproteins encoded by DNA tumor viruses. In this study we demonstrate that the E6 proteins of the oncogenic HPVs that bind p53 stimulate the degradation of p53. The E6-promoted degradation of p53 is ATP dependent and involves the ubiquitin-dependent protease system. Selective degradation of cellular proteins such as p53 with negative regulatory functions provides a novel mechanism of action for dominant-acting oncoproteins.
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Human papillomavirus protein E6 induces interactions between TP53 and E6-associated protein (E6-AP).
“Studying the human papillomavirus protein E6, they discovered that E6 induces interactions between two host proteins: TP53, involved in viral surveillance, and one that they named E6-associated protein (E6-AP).”
From Chasing molecular glue degraders: screening approaches (2022) · cites this paper as [93]
Cites
The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
Dyson, N., Howley, P. M., Münger, K., & Harlow, E. (1989) · Science · doi:10.1126/science.2537532 · Cited by 3,017 · see citing works
Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53
Werness, B. A., Levine, A. J., & Howley, P. M. (1990) · Science · doi:10.1126/science.2157286 · Cited by 2,562 · see citing works
Self-citationT antigen is bound to a host protein in SY40-transformed cells
Lane, D. P., & Crawford, L. V. (1979) · Nature · doi:10.1038/278261a0 · Cited by 2,443 · see citing works
Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas
Baker, S. J., Fearon, E. R., Nigro, J. M., Hamilton, S. R., Preisinger, A. C., Jessup, J. M., vanTuinen, P., Ledbetter, D. H., Barker, D. F., Nakamura, Y., et al. (1989) · Science · doi:10.1126/science.2649981 · Cited by 2,067 · see citing works
The p53 proto-oncogene can act as a suppressor of transformation
Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987 · see citing works
Self-citationLinzer, D. I. H., & Levine, A. J. (1979) · Cell · doi:10.1016/0092-8674(79)90293-9 · Cited by 1,814 · see citing works
Self-citationSuppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53
Baker, S. J., Markowitz, S. D., Fearon, E. R., Willson, J. K. V., & Vogelstein, B. (1990) · Science · doi:10.1126/science.2144057 · Cited by 1,742 · see citing works
Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
Schwarz, E., Freese, U. K., Gissmann, L., Mayer, W., Roggenbuck, B., Stremlau, A., & Hausen, H. Z. (1985) · Nature · doi:10.1038/314111a0 · Cited by 1,483 · see citing works
DeCaprio, J. A., Ludlow, J. W., Figge, J., Shew, J.-Y., Huang, C.-M., Lee, W.-H., Marsilio, E., Paucha, E., & Livingston, D. M. (1988) · Cell · doi:10.1016/0092-8674(88)90559-4 · Cited by 1,459 · see citing works
Whyte, P., Buchkovich, K. J., Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A., & Harlow, E. (1988) · Nature · doi:10.1038/334124a0 · Cited by 1,403 · see citing works
Münger, K., Phelps, W. C., Bubb, V. J., Howley, P. M., & Schlegel, R. (1989) · Journal of Virology · doi:10.1128/jvi.63.10.4417-4421.1989 · Cited by 1,335 · see citing works
Self-citationAllelotype of Colorectal Carcinomas
Vogelstein, B., Fearon, E. R., Kern, S. E., Hamilton, S. R., Preisinger, A. C., Nakamura, Y., & White, R. L. (1989) · Science · doi:10.1126/science.2565047 · Cited by 1,302 · see citing works
Münger, K., Werness, B. A., Dyson, N. J., Phelps, W. C., Harlow, E. E., & Howley, P. M. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08594.x · Cited by 1,204 · see citing works
Self-citationp53: A Frequent Target for Genetic Abnormalities in Lung Cancer
Takahashi, T., Nau, M. M., Chiba, I., Birrer, M. J., Rosenberg, R. K., Vinocour, M., Levitt, M. L., Pass, H. I., Gazdar, A. F., & Minna, J. D. (1989) · Science · doi:10.1126/science.2554494 · Cited by 1,196 · see citing works
Finlay, C. A., Hinds, P. W., Tan, T., Eliyahu, D., Oren, M., & Levine, A. J. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.2.531 · Cited by 1,144 · see citing works
Self-citationHPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.
Hawley‐Nelson, P., Vousden, K. H., Hubbert, N. L., Lowy, D. R., & Schiller, J. T. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08570.x · Cited by 914 · see citing works
Sarnow, P., Ho, Y.-S., Williams, J., & Levine, A. J. (1982) · Cell · doi:10.1016/0092-8674(82)90356-7 · Cited by 836 · see citing works
Self-citationPresence of a Potent Transcription Activating Sequence in the p53 Protein
Fields, S., & Jang, S. K. (1990) · Science · doi:10.1126/science.2144363 · Cited by 790 · see citing works
Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation
Parada, L. F., Land, H., Weinberg, R. A., Wolf, D., & Rotter, V. (1984) · Nature · doi:10.1038/312649a0 · Cited by 731 · see citing works
Cellular targets for transformation by the adenovirus E1A proteins
Whyte, P., Williamson, N. M., & Harlow, E. (1989) · Cell · doi:10.1016/0092-8674(89)90984-7 · Cited by 729 · see citing works
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells
Eliyahu, D., Raz, A., Gruß, P., Givol, D., & Oren, M. (1984) · Nature · doi:10.1038/312646a0 · Cited by 706 · see citing works
Wild-type p53 can inhibit oncogene-mediated focus formation.
Eliyahu, D., Michalovitz, D., Eliyahu, S., Pinhasi-Kimhi, O., & Oren, M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8763 · Cited by 681 · see citing works
Heterogeneity of the human papillomavirus group
de Villiers, E. M. (1989) · Journal of Virology · doi:10.1128/jvi.63.11.4898-4903.1989 · Cited by 668 · see citing works
Smotkin, D., & Wettstein, F. O. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4680 · Cited by 661 · see citing works
Phelps, W. C., Yee, C., Münger, K., & Howley, P. M. (1988) · Cell · doi:10.1016/0092-8674(88)90570-3 · Cited by 641 · see citing works
Self-citationTranscriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene
Raycroft, L., Wu, H., & Lozano, G. (1990) · Science · doi:10.1126/science.2144364 · Cited by 620 · see citing works
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Yee, C., Krishnan-Hewlett, I., Baker, C. C., et al. (1985) · PubMed · Cited by 607 · see citing works
Hinds, P. W., Finlay, C. A., & Levine, A. J. (1989) · Journal of Virology · doi:10.1128/jvi.63.2.739-746.1989 · Cited by 595 · see citing works
Self-citationCellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53
Jenkins, J. R., Rudge, K., & Currie, G. A. (1984) · Nature · doi:10.1038/312651a0 · Cited by 538 · see citing works
Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.
Oren, M., Maltzman, W., & Levine, A. J. (1981) · Molecular and Cellular Biology · doi:10.1128/mcb.1.2.101 · Cited by 489 · see citing works
Self-citationThe immunochemical detection and quantitation of intracellular ubiquitin-protein conjugates.
Haas, A. L., & Bright, P. M. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38895-6 · Cited by 382 · see citing works
Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus
Mowat, M. R. A., Cheng, A., Kimura, N., Bernstein, A., & Benchimol, S. (1985) · Nature · doi:10.1038/314633a0 · Cited by 320 · see citing works
Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53.
Reich, N. C., Oren, M., & Levine, A. J. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.12.2143 · Cited by 310 · see citing works
Self-citationComparison of the in vitro transforming activities of human papillomavirus types.
Storey, A., Pim, D. C., Murray, A., Osborn, K., Banks, L., & Crawford, L. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03013.x · Cited by 301 · see citing works
The Role of Papillomaviruses in Human Anogenital Cancer
Hausen, H. Z., & Schneider, A. (1987) · Springer eBooks · doi:10.1007/978-1-4757-0584-3_9 · Cited by 272 · see citing works
Wolf, D., Harris, N., & Rotter, V. (1984) · Cell · doi:10.1016/0092-8674(84)90532-4 · Cited by 245 · see citing works
Meth A fibrosarcoma cells express two transforming mutant p53 species.
Eliyahu, D., Goldfinger, N., Pinhasi-Kimhi, O., Shaulsky, G., Skurnik, Y. D., Arai, N., Rotter, V., & Oren, M. (1988) · PubMed · Cited by 233 · see citing works
Ewen, M. E., Ludlow, J. W., Marsilio, E., DeCaprio, J. A., Millikan, R. C., Cheng, S. H., Paucha, E., & Livingston, D. M. (1989) · Cell · doi:10.1016/0092-8674(89)90840-4 · Cited by 228 · see citing works
Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.
Zakut, R., Bienz-Tadmor, B., Givol, D., & Oren, M. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03768.x · Cited by 218 · see citing works
Watanabe, S., Kanda, T., & Yoshiike, K. (1989) · Journal of Virology · doi:10.1128/jvi.63.2.965-969.1989 · Cited by 174 · see citing works
Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells
Bedell, M. A., Jones, K. H., Grossman, S. R., et al. (1989) · Journal of Virology · doi:10.1128/jvi.63.3.1247-1255.1989 · Cited by 169 · see citing works
Immortalization of rat embryo fibroblasts by the cellular p53 oncogene.
Rovinski, B., & Benchimol, S. (1988) · PubMed · Cited by 156 · see citing works
Cis-trans recognition and subunit-specific degradation of short-lived proteins
Johnson, E. S., Gonda, D. K., & Varshavsky, A. (1990) · Nature · doi:10.1038/346287a0 · Cited by 152 · see citing works
Analysis of human p53 proteins and mRNA levels in normal and transformed cells
Matlashewski, G., Banks, L., Pim, D., & Crawford, L. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09449.x · Cited by 137 · see citing works
The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene.
Kh, V., Doniger, J., DiPaolo, J. A., et al. (1988) · PubMed · Cited by 129 · see citing works
How are substrates recognized by the ubiquitin-mediated proteolytic system
Ciechanover, A. J., & Schwartz, A. L. (1989) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(89)90180-1 · Cited by 127 · see citing works
Figge, J. J., Webster, T. A., Smith, T. F., & Paucha, E. (1988) · Journal of Virology · doi:10.1128/jvi.62.5.1814-1818.1988 · Cited by 117 · see citing works
Kanda, T., Watanabe, S., & Yoshiike, K. (1988) · Virology · doi:10.1016/0042-6822(88)90694-0 · Cited by 112 · see citing works
Inducible and constitutive enhancer domains in the noncoding region of human papillomavirus type 18
Gius, D. R., Grossman, S. R., Bedell, M. A., et al. (1988) · Journal of Virology · doi:10.1128/jvi.62.3.665-672.1988 · Cited by 93 · see citing works
Wild type human p53 is antiproliferative in SV40-transformed hamster cells.
Mercer, W. E., Amin, M., Sauvé, G. J., Appella, E., Sj, U., & Romano, J. (1990) · PubMed · Cited by 91 · see citing works
Identification of a transforming gene of human papillomavirus type 16
Tanaka, A., Noda, T., Yajima, H., et al. (1989) · Journal of Virology · doi:10.1128/jvi.63.3.1465-1469.1989 · Cited by 71 · see citing works
Transforming collaborations between ras and nuclear oncogenes.
He, R. (1990) · PubMed · Cited by 70 · see citing works
Transformation of rat 3Y1 cells by human papillomavirus type‐18 DNA
Watanabe, S., & Yoshiike, K. (1988) · International Journal of Cancer · doi:10.1002/ijc.2910410622 · Cited by 55 · see citing works
Transcriptional activation by the papillomavirus E6 zinc finger oncoprotein.
Lamberti, C., Morrissey, L. C., Grossman, S. R., et al. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08317.x · Cited by 52 · see citing works
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Sorted by citations
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · see citing works
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047 · see citing works
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,559 · see citing works
The first 30 years of p53: growing ever more complex.
Levine, A. J., & Oren, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2723 · Cited by 1,967 · see citing works
Self-citationZhang, Y., Xiong, Y., & Yarbrough, W. G. (1998) · Cell · doi:10.1016/s0092-8674(00)81401-4 · Cited by 1,626 · see citing works
Kiyono, T., Foster, S. A., Koop, J. I., McDougall, J. K., Galloway, D. A., & Klingelhutz, A. J. (1998) · Nature · doi:10.1038/23962 · Cited by 1,206 · see citing works
ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
Zhao, H., & Piwnica-Worms, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4129-4139.2001 · Cited by 1,091 · see citing works
p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086 · see citing works
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016 · see citing works
The MDM2 gene amplification database
Momand, J. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.15.3453 · Cited by 982 · see citing works
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L., & Bedi, A. (2000) · Genes & Development · doi:10.1101/gad.14.1.34 · Cited by 967 · see citing works
Gain of function mutations in p53
Dittmer, D., Pati, S., Zambetti, G., Chu, S., Teresky, A. K., Moore, M., Finlay, C., & Levine, A. J. (1993) · Nature Genetics · doi:10.1038/ng0593-42 · Cited by 894 · see citing works
Self-citationHuibregtse, J. M., Scheffner, M., & Howley, P. M. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04990.x · Cited by 879 · see citing works
Self-citationThe N-end rule: functions, mysteries, uses
Varshavsky, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12142 · Cited by 859 · see citing works
MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells
Papagiannakopoulos, T., Shapiro, A., & Kosik, K. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1305 · Cited by 705 · see citing works
MDMX: a novel p53‐binding protein with some functional properties of MDM2.
Shvarts, A., Steegenga, W. T., Riteco, N., van Laar, T., Dekker, P., Bazuine, M., van Ham, R. C., van der Houven van Oordt, W., Hateboer, G., van der Eb, A. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00919.x · Cited by 648 · see citing works
Wild-type p53 activates transcription in vitro
Farmer, G., Bargonetti, J., Zhu, H., Friedman, P., Prywes, R., & Prives, C. (1992) · Nature · doi:10.1038/358083a0 · Cited by 579 · see citing works
p300/MDM2 complexes participate in MDM2-mediated p53 degradation
Grossman, S. R., Perez, M., Kung, A. L., Joseph, M., Mansur, C., Xiao, Z.-X., Kumar, S., Howley, P. M., & Livingston, D. M. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80140-9 · Cited by 414 · see citing works
Self-citationThe mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.
Finlay, C. A. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.301 · Cited by 311 · see citing works
Regulation of the Human hsp70 Promoter by p53
Agoff, S. N., Hou, J., Linzer, D. I., & Wu, B. (1993) · Science · doi:10.1126/science.8418500 · Cited by 292 · see citing works
Interaction of Papillomavirus E6 Oncoproteins with a Putative Calcium-Binding Protein
Chen, J. J., Reid, C. E., Band, V., & Androphy, E. J. (1995) · Science · doi:10.1126/science.7624774 · Cited by 275 · see citing works
Hara, E., Tsurui, H., Shinozaki, A., Nakada, S., & Oda, K. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91403-y · Cited by 260 · see citing works
DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation
Moiseeva, O., Mallette, F. A., Mukhopadhyay, U. K., Moores, A., & Ferbeyre, G. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-09-0858 · Cited by 252 · see citing works
Keller, J. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(01)00006-x · Cited by 247 · see citing works
Mdm2 binds p73α without targeting degradation
Bálint, E., Bates, S., & Vousden, K. H. (1999) · Oncogene · doi:10.1038/sj.onc.1202781 · Cited by 212 · see citing works
Cancer cell signaling pathways targeted by spice-derived nutraceuticals
Sung, B., Prasad, S., Yadav, V. R., & Aggarwal, B. B. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.630551 · Cited by 204 · see citing works
Chasing molecular glue degraders: screening approaches
Domostegui, A., Nieto-Barrado, L., Perez-Lopez, C., & Mayor-Ruiz, C. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00197g · Cited by 200 · see citing works
Nominé, Y., Masson, M., Charbonnier, S., Zanier, K., Ristriani, T., Deryckère, F., Sibler, A.-P., Desplancq, D., Atkinson, R. A., Weiss, E., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.024 · Cited by 177 · see citing works
The many faces of p53: something for everyone
Levine, A. J. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz026 · Cited by 163 · see citing works
Self-citationMunro, J., Barr, N. I., Ireland, H., Morrison, V., & Parkinson, E. K. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.01.017 · Cited by 141 · see citing works
Brimer, N., Lyons, C., Wallberg, A. E., & Vande Pol, S. B. (2012) · Oncogene · doi:10.1038/onc.2011.589 · Cited by 133 · see citing works
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
LeBron, C., Chen, L., Gilkes, D. M., & Chen, J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601032 · Cited by 122 · see citing works
Wild-Type Human p53 Transactivates the Human Proliferating Cell Nuclear Antigen Promoter
Shivakumar, C. V., Brown, D. R., Deb, S., & Deb, S. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6785 · Cited by 120 · see citing works
P53 and The Immune Response: 40 Years of Exploration—A Plan for the Future
Levine, A. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020541 · Cited by 97 · see citing works
Self-citationVogt Sionov, R., Coen, S., Goldberg, Z., Berger, M., Bercovich, B., Ben-Neriah, Y., Ciechanover, A., & Haupt, Y. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5869-5878.2001 · Cited by 94 · see citing works
Tong, X., O'Kelly, J., Xie, D., Mori, A., Lemp, N., McKenna, R., Miller, C. W., & Koeffler, H. P. (2004) · Oncogene · doi:10.1038/sj.onc.1207628 · Cited by 86 · see citing works
RetractedReplicative senescence revisited.
Marcotte, R., & Wang, E. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.7.b257 · Cited by 86 · see citing works
Targeting Therapies for the p53 Protein in Cancer Treatments
Levine, A. J. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055455 · Cited by 84 · see citing works
Self-citationThe G2 DNA Damage Checkpoint Delays Expression of Genes Encoding Mitotic Regulators
Crawford, D. F., & Piwnica-Worms, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103414200 · Cited by 79 · see citing works
Regulation of the p53 Family Proteins by the Ubiquitin Proteasomal Pathway
Bang, S., Kaur, S., & Kurokawa, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010261 · Cited by 69 · see citing works
Sanduja, S., Kaza, V., & Dixon, D. A. (2009) · Aging · doi:10.18632/aging.100086 · Cited by 65 · see citing works
O’Connor, H. F., & Huibregtse, J. M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2529-6 · Cited by 42 · see citing works
Self-citationThe struggle of a good friend getting old: cellular senescence in viral responses and therapy
Kohli, J., Veenstra, I., & Demaria, M. (2021) · The EMBO Reports · doi:10.15252/embr.202052243 · Cited by 52 · see citing works
Ali, D., Mohammad, D. K., Mujahed, H., Jonson‐Videsäter, K., Nore, B., Paul, C., & Lehmann, S. (2016) · British Journal of Haematology · doi:10.1111/bjh.14036 · Cited by 49 · see citing works
Viral hijacking of host caspases: an emerging category of pathogen–host interactions
Connolly, P. F., & Fearnhead, H. O. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.59 · Cited by 44 · see citing works
Insights into regulators of p53 acetylation
Nagasaka, M., Miyajima, C., Aoki, H., Aoyama, M., Morishita, D., Inoue, Y., & Hayashi, H. (2022) · Cells · doi:10.3390/cells11233825 · Cited by 45 · see citing works
Small-molecule correctors and stabilizers to target p53
Fallatah, M. M. J., Law, F. V., Chow, W. A., & Kaiser, P. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.02.007 · Cited by 44 · see citing works
Tong, W. W. Y., Shepherd, K., Garland, S., Meagher, A., Templeton, D. J., Fairley, C. K., Jin, F., Poynten, I. M., Zaunders, J., Hillman, R. J., et al. (2015) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu461 · Cited by 36 · see citing works
p53 is dispensable for UV-induced cell cycle arrest at late G1 in mammalian cells
Al-Mohanna, M. A., Al-Khodairy, F. M., Krezolek, Z., Bertilsson, P.-A., Al-Houssein, K. A., & Aboussekhra, A. (2001) · Carcinogenesis · doi:10.1093/carcin/22.4.573 · Cited by 30 · see citing works
Human papilloma virus, papanicolaou smears, and the college female
Moscicki, A.-B. (2005) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2004.10.005 · Cited by 24 · see citing works
Interleukin-1α associates with the tumor suppressor p53 following DNA damage
Novak, J., Zamostna, B., Vopalensky, V., Buryskova, M., Burysek, L., Doleckova, D., & Pospisek, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-63779-x · Cited by 3 · see citing works
- Authors
- Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., & Howley, P. M.
- Affiliations
- National Cancer Institute (US)
- Princeton University (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1990-12
- Volume
- 63
- Issue
- 6
- Pages
- 1129-1136
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2039382131
- Cited by
- 3,995
- References
- 54
- Citations by year
- 2026: 68 · 2025: 62 · 2024: 68 · 2023: 87 · 2022: 85 · 2021: 87 · 2020: 98 · 2019: 91 · 2018: 97 · 2017: 103 · 2016: 102 · 2015: 105 · 2014: 107 · 2013: 112 · 2012: 156
- FWCI
- 39.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- E6 oncoprotein, HPV16, HPV 18, p53 degradation, ubiquitin-mediated proteolysis, tumor suppressor proteins, HPV-associated cancers, keratinocyte immortalization
- MeSH terms
- Antigens, Polyomavirus Transforming, DNA-Binding Proteins, Humans, Oncogene Proteins, Viral, Endopeptidases, Protein Binding, RNA, Messenger, Transcription, Genetic, Protein Biosynthesis, Ubiquitins, Blotting, Western, Tumor Suppressor Protein p53, Papillomaviridae
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