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Physical and Chemical Studies on Ceruloplasmin
Open accessAbstract
Abstract The survival time in plasma of incompletely desialylated ceruloplasmin, labeled with 64Cu or with tritium, was studied in the rat. Removal of less than 20% of the terminal sialic acid, with consequent exposure of the penultimate galactosyl residues, resulted in the rapid disappearance from the circulation of more than 50% of the injected dose. Statistical analysis of the experimental results by means of the Poisson distribution equation supports the estimate that the exposure of no more than 2 galactosyl residues is sufficient to effect prompt clearance of ceruloplasmin from the circulation. Examination of the specificity of the two neuraminidase preparations used in this study revealed that each of the enzymes possessed a preferential affinity for different sialic acid residues, although the results from each were statistically predictable. Consequently, the removal of any 2 sialic acid residues from 1 molecule of ceruloplasmin appears to be incompatible with the continued survival of that molecule in the circulation.
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Cited by
De Duve, C., De Barsy, T., Poole, B., Trouet, A., Tulkens, P., & Van Hoof, F. (1974) · Biochemical Pharmacology · doi:10.1016/0006-2952(74)90174-9 · Cited by 1,901
The role of sialic acid in determining the survival of glycoproteins in the circulation
Morell, A. G., Gregoriadis, G., Scheinberg, I. H., Hickman, J., & Ashwell, G. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76994-4 · Cited by 1,072
Self-citationGalNAc-siRNA conjugates: leading the way for delivery of RNAi therapeutics
Springer, A. D., & Dowdy, S. F. (2018) · Nucleic Acid Therapeutics · doi:10.1089/nat.2018.0736 · Cited by 711
The Isolation and Properties of a Rabbit Liver Binding Protein Specific for Asialoglycoproteins
Hudgin, R. L., Pricer, W. E., Ashwell, G., Stockert, R. J., & Morell, A. G. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)79761-9 · Cited by 615
Self-citationStudies on the Chemical and Enzymatic Modification of Glycoproteins
Van Lenten, L., & Ashwell, G. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62392-0 · Cited by 488
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Metadata
- Authors
- van den Hamer, C. J. A., Morell, A. G., Scheinberg, I. H., Hickman, J., & Ashwell, G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1970-09
- Volume
- 245
- Issue
- 17
- Pages
- 4397-4402
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1661968451
- Cited by
- 183
- References
- 0
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- van den Hamer, C. J. A., Morell, A. G., Scheinberg, I. H., Hickman, J., & Ashwell, G. (1970). Physical and Chemical Studies on Ceruloplasmin. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)63808-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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