The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.
Open accessAbstract
Administration of Cd, Zn, Cu, or Hg increases the rate of transcription from the metallothionein-I gene in mouse liver and kidney. Maximal transcription rates occur 1 h after Cd administration in both tissues. Metallothionein-I mRNA levels, measured by cDNA hybridization, and metallothionein protein synthesis, measured by [35S]cysteine incorporation, increase simultaneously, reaching maximal levels about 4 h after Cd administration. Cd also induces metallothionein-I mRNA in all other tissues examined (spleen, heart, skeletal muscle, brain, and intestine) except testes. Comparison of the inductions by Cd and Hg shows that the kinetics of metallothionein-I mRNA accumulation as well as the stability of the resultant metallothioneins differ.
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Cites
A simple, rapid, and sensitive DNA assay procedure
Labarca, C., & Paigen, K. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90165-7 · Cited by 4,901
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McKnight, G. S., & Palmiter, R. D. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86807-2 · Cited by 929
Self-citationStanley McKnight, G. (1978) · Cell · doi:10.1016/0092-8674(78)90125-3 · Cited by 199
Isolation and characterization of the mouse metallothionein-I gene.
Durnam, D. M., Perrin, F., Gannon, F., & Palmiter, R. D. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.11.6511 · Cited by 196
Self-citationIsolation of an intestinal metallothionein induced by parenteral zinc
Richards, M. P., & Cousins, R. J. (1977) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(77)91041-5 · Cited by 101
Shapiro, S. G., Squibb, K. S., Markowitz, L. A., & Cousins, R. J. (1978) · Biochemical Journal · doi:10.1042/bj1750833 · Cited by 78
Synthesis of metallothionein in a polysomal cell-free system
Squibb, K. S., & Cousins, R. J. (1977) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(77)91544-3 · Cited by 77
Studies on the appearance of a hepatic copper-binding protein in normal and zinc-deficient rats
Bremner, I., & Davies, N. T. (1976) · British Journal Of Nutrition · doi:10.1079/bjn19760061 · Cited by 66
Kinetics of cadmium-induced hepatic and renal metallothionein synthesis in the mouse
Probst, G. S., Bousquet, W. F., & Miya, T. S. (1977) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(77)90176-4 · Cited by 65
Cited by
CpG-rich islands and the function of DNA methylation
Bird, A. P. (1986) · Nature · doi:10.1038/321209a0 · Cited by 3,777
Regulation of metallothionein gene expression by oxidative stress and metal ions
Andrews, G. K. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00301-9 · Cited by 834
Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice
Palmiter, R. D., Norstedt, G., Gelinas, R. E., Hammer, R. E., & Brinster, R. L. (1983) · Science · doi:10.1126/science.6356363 · Cited by 676
Self-citationDNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells
Compere, S. J., & Palmiter, R. D. (1981) · Cell · doi:10.1016/0092-8674(81)90248-8 · Cited by 465
Self-citationMichalska, A. E., & Choo, K. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8088 · Cited by 377
Metadata
- Authors
- Durnam, D. M., & Palmiter, R. D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1981-06
- Volume
- 256
- Issue
- 11
- Pages
- 5712-5716
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1604713610
- Cited by
- 585
- References
- 11
- FWCI
- 29.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Durnam, D. M., & Palmiter, R. D. (1981). Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)69264-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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