The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse.
Open accessAbstract
We report the generation of transgenic mice deficient in the metallothionein MT-I and MT-II genes. The mutations were introduced into embryonic stem cells by homologous recombination. Chimeric mice resulting from the targeted embryonic stem cells transmitted the disrupted alleles through their germ line. Homozygous animals were born alive and appeared phenotypically normal and fertile. Absence of MT proteins was confirmed by direct measurement in liver extracts. Challenging the mutant animals with moderate levels of CdSO4 indicated their greater susceptibility to cadmium toxicity than wild-type animals. These mice should provide a useful model to allow detailed study of the physiological roles of MT-I and MT-II.
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Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
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Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
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An Animal Model for Cystic Fibrosis Made by Gene Targeting
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Cited by
Metallothionein: the multipurpose protein
Coyle, P., Philcox, J. C., Carey, L. C., & Rofe, A. M. (2002) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-002-8454-2 · Cited by 1,304
The Human Obesity Gene Map: The 2005 Update
Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C. (2006) · Obesity · doi:10.1038/oby.2006.71 · Cited by 1,119
REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN
Dalton, T. P., Shertzer, H. G., & Puga, A. (1999) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.67 · Cited by 1,118
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053
The Function of Zinc Metallothionein: A Link between Cellular Zinc and Redox State
Maret, W. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.5.1455s · Cited by 416
Metadata
- Authors
- Michalska, A. E., & Choo, K. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-09
- Volume
- 90
- Issue
- 17
- Pages
- 8088-8092
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2031121245
- Cited by
- 377
- References
- 26
- FWCI
- 20.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Michalska, A. E., & Choo, K. H. (1993). Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.17.8088
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
