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Specific cleavage of human type III collagen by human polymorphonuclear leukocyte elastase.
Open accessAbstract
Purified polymorphonuclear leukocyte elastase degraded native human liver type III collagen at 27 degrees C by making a cleavage through the triple helix. The enzyme had no effect on human type I collagen. The reaction was inhibited by phenylmethanesulfonyl fluoride (PhCH2SO2F) but not by EDTA. The collagen reaction products were identical with those generated by human rheumatoid synovial collagenase when analyzed by polyacrylamide gel electrophoresis and gel filtration. NH2-trminal sequence analysis indicated that the enzyme cleaved at an isoleucyl-threonyl bond located 4 residues on the carboxyl side of the established cleavage site for animal collagenases. Therefore, it is likely that in pathologic states, type III collagen can be selectively depleted from the matrix by this enzyme.
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Cited by
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Fields, G. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.451211 · Cited by 205
Leukocyte proteinases in wound healing: roles in physiologic and pathologic processes
Barrick, B., Campbell, E. J., & Owen, C. A. (1999) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1999.00410.x · Cited by 134
Parkin, J. D., San Antonio, J. D., Persikov, A. V., Dagher, H., Dalgleish, R., Jensen, S. T., Jeunemaitre, X., & Savige, J. (2017) · PLOS ONE · doi:10.1371/journal.pone.0175582 · Cited by 39
Metadata
- Authors
- Mainardi, C. L., Hasty, D. L., Seyer, J. M., & Kang, A. H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1980-12
- Volume
- 255
- Issue
- 24
- Pages
- 12006-12010
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1570767037
- Cited by
- 159
- References
- 0
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Specific cleavage of human type III collagen by human polymorphonuclear leukocyte elastase. https://app.cochat.ai/papers/10.1016/s0021-9258(19)70234-8
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- Mainardi, C. L., Hasty, D. L., Seyer, J. M., & Kang, A. H. (1980). Specific cleavage of human type III collagen by human polymorphonuclear leukocyte elastase. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)70234-8
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
