The collαgen III fibril has a “flexi-rod” structure of flexible sequences interspersed with rigid bioactive domains including two with hemostatic roles
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Collagen III is critical to the integrity of blood vessels and distensible organs, and in hemostasis. Examination of the human collagen III interactome reveals a nearly identical structural arrangement and charge distribution pattern as for collagen I, with cell interaction domains, fibrillogenesis and enzyme cleavage domains, several major ligand-binding regions, and intermolecular crosslink sites at the same sites. These similarities allow heterotypic fibril formation with, and substitution by, collagen I in embryonic development and wound healing. The collagen III fibril assumes a "flexi-rod" structure with flexible zones interspersed with rod-like domains, which is consistent with the molecule's prominence in young, pliable tissues and distensible organs. Collagen III has two major hemostasis domains, with binding motifs for von Willebrand factor, α2β1 integrin, platelet binding octapeptide and glycoprotein VI, consistent with the bleeding tendency observed with COL3A1 disease-causing sequence variants.
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The human COLLIII interactome revealed a nearly identical structural arrangement and functional domains as for COLLI, including cell interaction, fibrillogenesis and enzyme cleavage domains, intermolecular crosslink sites, and several MLBRs for different ECM components.
“More recently, the definition of the human COLLIII interactome revealed a nearly identical structural arrangement and functional domains as for COLLI, including cell interaction, fibrillogenesis and enzyme cleavage domains, intermolecular crosslink sites, and several MLBRs for different ECM components, such as other COLLs, PGs, and FN [24].”
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Flagged first, then by citations
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Cited by
Sorted by citations
Chiarelli, N., Carini, G., Zoppi, N., Ritelli, M., & Colombi, M. (2018) · PLOS ONE · doi:10.1371/journal.pone.0191220 · Cited by 45 · see citing works
- Authors
- Parkin, J. D., San Antonio, J. D., Persikov, A. V., Dagher, H., Dalgleish, R., Jensen, S. T., Jeunemaitre, X., & Savige, J.
- Affiliations
- The University of Melbourne (AU)
- Princeton University (US)
- University of Leicester (GB)
- University of Pennsylvania (US)
- Corresponding author
- Parkin, J. Des
- Persikov, Anton V.
- Dagher, Hayat
- Dalgleish, Raymond
- Jensen, Shane T.
- Savige, Judy
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-07-13
- Volume
- 12
- Issue
- 7
- Pages
- e0175582
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5509119
- OpenAlex
- W2734776539
- Cited by
- 39
- References
- 123
- Citations by year
- 2026: 8 · 2025: 1 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 1
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Leicester Research Archive (University of Leicester) (submittedVersion, cc-by)
- Funders
- Stryker
- Topics
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Keywords
- type III collagen, collagen fibril structure, hemostasis, von Willebrand factor binding, alpha2beta1 integrin, glycoprotein VI, COL3A1, fibril formation, ligand-binding domain, wound healing, embryonic development
- MeSH terms
- Amino Acid Sequence, Binding Sites, Hemostasis, Humans, Platelet Membrane Glycoproteins, Protein Binding, von Willebrand Factor, Collagen Type III, Integrin alpha2beta1, Protein Stability, Protein Interaction Maps
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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