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Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid.
Open accessAbstract
Rabbit peritoneal polymorphonuclear leukocytes, elicited with glycogen, metabolized added [1-14C]arachidonic acid to the 5-lipoxygenase products 5-hydroxy-6,8,11,14-eicosatetraenoic acid and 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid (leukotriene B) and the 15-lipoxygenase product 15-hydroxy-5,8,11,13-eicosatetraenoic acid. These metabolites were isolated by high pressure liquid chromatography and converted to the trimethylsilyl-ether methyl ester derivatives, and the structures were confirmed by gas chromatography-mass spectrometry. When polymorphonuclear leukocytes were preincubated with 15-HETE (16 microM), the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid and 5,12-dihydroxy-6,8,10,14-eicostatetraenoic acid from [1-14C]arachidonic acid was strongly suppressed. The concentration required for 50% inhibition of the 5-lipoxygenase pathway in these cells was approximately 6 microM, which is comparable to the concentrations (0.20 to 1.8 microM) of 15-hydroxy-5,8,11,13-eicosatetraenoic acid produced in incubations of polymorphonuclear leukocytes with arachidonic acid alone. Recent reports indicate that slow-reacting substance of anaphylaxis (leukotriene C/D) and chemotactic substance leukotriene B are arachidonic acid metabolites formed via the 5-lipoxygenase pathway. Our observations thus suggest that 15-hydroxy-5,8,11,13-eicosatetraenoic acid can regulate the formation of these vasoactive and inflammatory mediators intracellularly.
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Citations
Cited by
Meade, E. A., Smith, W. L., & DeWitt, D. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53294-4 · Cited by 1,256
Release of Prostaglandin D2into Human Airways during Acute Antigen Challenge
Murray, J. J., Tonnel, A. B., Brash, A. R., Roberts, L. J., Gosset, P., Workman, R., Capron, A., & Oates, J. A. (1986) · New England Journal of Medicine · doi:10.1056/nejm198609253151304 · Cited by 469
Hydroxyeicosatetraenoic acids (HETEs)
Spector, A. A., Gordon, J. A., & Moore, S. A. (1988) · Progress in Lipid Research · doi:10.1016/0163-7827(88)90009-4 · Cited by 302
The pathogenesis of chronic obstructivepulmonary disease of horses
Robinson, N. E., Derksen, F. J., Olszewski, M. A., & Buechner-Maxwell, V. A. (1996) · British Veterinary Journal · doi:10.1016/s0007-1935(96)80101-1 · Cited by 261
Johnson, M. M., Swan, D. D., Surette, M. E., Stegner, J., Chilton, T., Fonteh, A. N., & Chilton, F. H. (1997) · The Journal of Nutrition · doi:10.1093/jn/127.8.1435 · Cited by 195
Metadata
- Authors
- Vanderhoek, J. Y., Bryant, R. W., & Bailey, J. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1980-11
- Volume
- 255
- Issue
- 21
- Pages
- 10064-10066
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1517088677
- Cited by
- 325
- References
- 0
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid. https://app.cochat.ai/papers/10.1016/s0021-9258(19)70428-1
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- Vanderhoek, J. Y., Bryant, R. W., & Bailey, J. M. (1980). Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)70428-1
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