The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Release of Prostaglandin D2into Human Airways during Acute Antigen Challenge
Abstract
Among the many possible mediators of the early asthmatic response, prostaglandin D2, a bronchoconstrictor, is the principal cyclooxygenase metabolite of arachidonic acid that is released upon the activation of mast cells and is also synthesized by human alveolar macrophages. We performed bronchoalveolar lavage in five patients with chronic stable asthma, before and up to nine minutes after local provocative challenge with Dermatophagoides pteronyssinus. The lavage fluid was analyzed for products of arachidonic acid metabolism. Prostaglandin D2 levels in all five patients rose an average of 150-fold, from less than 8 to 332 +/- 114 pg per milliliter (mean +/- SEM; P less than 0.050), after local instillation of the antigen. Levels of 15-hydroxyeicosatetraenoic acid, which may also have a role in the pulmonary allergic response, were detectable in lavage fluid before challenge and increased after provocation with the antigen in four of the five patients. The activity of beta-glucuronidase, an enzyme released by macrophages and mast cells upon stimulation, tended to increase in the lavage fluid after provocation in all patients. These studies provide evidence that the release of prostaglandin D2 into the airways is an early event after the instillation of D. pteronyssinus in patients who are sensitive to this antigen.
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Cites
Local Effects of Synthetic Leukotrienes (LTC4, LTD4, and LTB4) in Human Skin
Soter, N. A., Lewis, R. A., Corey, E. J., & Austen, K. F. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12531738 · Cited by 589
Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.
Lewis, R. A., Soter, N. A., Diamond, P. T., Austen, K. F., Oates, J. A., & Roberts, L. J. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.4.1627 · Cited by 584
Self-citationIncreased production of prostaglandin D2 in patients with systemic mastocytosis
Roberts, L. J., Sweetman, B. J., Lewis, R. A., Austen, K. F., & Oates, J. A. (1980) · New England Journal of Medicine · doi:10.1056/nejm198012113032405 · Cited by 423
Self-citationVanderhoek, J. Y., Bryant, R. W., & Bailey, J. M. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70428-1 · Cited by 325
The Bronchoconstrictor Effect of Inhaled Prostaglandin D2 in Normal and Asthmatic Men
Hardy, C. C., Robinson, C., Tattersfield, A. E., & Holgate, S. T. (1984) · New England Journal of Medicine · doi:10.1056/nejm198407263110401 · Cited by 316
Effects of Leukotriene D on the Airways in Asthma
Griffin, M. P., Weiss, J. W., Leitch, A. G., McFadden, E. R., Corey, E. J., Austen, K. F., & Drazen, J. M. (1983) · New England Journal of Medicine · doi:10.1056/nejm198302243080807 · Cited by 284
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GASTRIC CANCER IN PATIENTS WHO HAVE TAKEN CIMETIDINE
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Self-citationPreparation and assay of monohydroxy-eicosatetraenoic acids
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Cited by
Lewis (1990) · doi:10.1056/nejm199009063231006 · Cited by 1,200
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis
Schwartz, L. B., Metcalfe, D. D., Miller, J. S., Earl, H., & Sullivan, T. (1987) · New England Journal of Medicine · doi:10.1056/nejm198706253162603 · Cited by 784
Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor
Monneret, G., Gravel, S., Diamond, M., Rokach, J., & Powell, W. S. (2001) · Blood · doi:10.1182/blood.v98.6.1942 · Cited by 326
Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases
Pettipher, R., Hansel, T. T., & Armer, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2266 · Cited by 317
Evidence That Histamine Is the Causative Toxin of Scombroid-Fish Poisoning
Morrow, J. D., Margolies, G. R., Rowland, J., & Roberts, L. J. (1991) · New England Journal of Medicine · doi:10.1056/nejm199103143241102 · Cited by 313
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Metadata
- Authors
- Murray, J. J., Tonnel, A. B., Brash, A. R., Roberts, L. J., Gosset, P., Workman, R., Capron, A., & Oates, J. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1986-09-25
- Volume
- 315
- Issue
- 13
- Pages
- 800-804
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2331980604
- Cited by
- 469
- References
- 20
- FWCI
- 19.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Murray, J. J., Tonnel, A. B., Brash, A. R., Roberts, L. J., Gosset, P., Workman, R., Capron, A., & Oates, J. A. (1986). Release of Prostaglandin D2into Human Airways during Acute Antigen Challenge. New England Journal of Medicine. https://doi.org/10.1056/nejm198609253151304
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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