The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
A novel group of very long chain polyenoic fatty acids in dipolyunsaturated phosphatidylcholines from vertebrate retina
Open accessAbstract
Dipolyunsaturated phosphatidylcholines from bovine retina contain a whole series of unusual fatty acids. Methyl esters from these acids are very strongly retained on polar and nonpolar gas-liquid chromatography stationary phases. On thin layers of silica-AgNO3, they separate as tetra-, penta-, and hexaenoic fatty acid methyl esters. After hydrogenation, the three polyunsaturated fractions give the same series of saturated methyl esters, having 20 (or 22)-36 carbon atoms. High pressure liquid chromatography, as well as gas-liquid chromatography, indicates that the new components of the three fractions are even-carbon homologs of well known polyenoic fatty acids of the n-6 and n-3 families, since they behave as series of 20-36-carbon tetraenoic (n-6), pentaenoic (n-3 and n-6), and hexaenoic (n-3) fatty acids. Their occurrence in phospholipid molecules also having docosahexaenoate (22:6) explains the separation of major dipolyunsaturated phosphatidylcholines from retina into dodecaenoic, undecaenoic, and decaenoic fractions after argentation thin layer chromatography. Using high pressure liquid chromatography, the latter are resolved into individual species having 10-12 double bonds and 42-58 carbon atoms. The unusual PCs are thus endowed not only with the highest degree of unsaturation, but with the longest hydrocarbon chains yet reported for vertebrate glycerophospholipids. It is shown that phosphatidylcholines containing the novel fatty acids are highly concentrated in photoreceptor membranes and that they occur in the retina of vertebrates so distant in evolution as fish, birds, and various mammals.
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“After VLC-PUFAs are generated via ELOVL4, they are incorporated into phospholipids in the PRC inner segment, where they become part of the PRC outer membrane biogenesis (Aveldaño, 1987) and tightly interact with rhodopsin (Aveldaño, 1988),”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Aveldaño, 1987
In the citing paper
“ELOVL4 synthesizes VLC-PUFAs in the retina (Agbaga et al., 2010, 2008; Aveldaño, 1987) and testes (Oresti et al., 2010), and it synthesizes very-long-chain saturated fatty acids (VLC-SFAs) in the skin and brain (Cameron et al., 2007; Monroig et al., 2010).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Aveldaño, 1987
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Cites
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
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Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol
Morrison, W. R., & Smith, L. M. (1964) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40190-7 · Cited by 6,005
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Structural and Metabolic Heterogeneity of Rat Liver Glycerophosphatides
Arvidson, G. (1968) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1968.tb00237.x · Cited by 457
Membrane Fatty Acids Associated with the Electrical Response in Visual Excitation
Benolken, R. M., Anderson, R. E., & Wheeler, T. G. (1973) · Science · doi:10.1126/science.182.4118.1253 · Cited by 321
[8] Preparation of retinal rod outer segments
Papermaster, D. S. (1982) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(82)81010-0 · Cited by 281
Aveldaño, M. I., VanRollins, M., & Horrocks, L. A. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38027-5 · Cited by 201
Miljanich, G. P., Sklar, L. A., White, D. L., & Dratz, E. A. (1979) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(79)90284-0 · Cited by 161
ACKMAN, R. G. (1963) · Journal of the American Oil Chemists Society · doi:10.1007/bf02822466 · Cited by 147
Aveldaño, M. I., & Sprecher, H. W. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75768-8 · Cited by 145
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The Essentiality Of N-3 Fatty Acids For The Development And Function Of The Retina And Brain
Neuringer, M., Anderson, G. J., & Connor, W. E. (1988) · Annual Review of Nutrition · doi:10.1146/annurev.nu.08.070188.002505 · Cited by 739
Castro, L. F. C., Tocher, D. R., & Monroig, Ó. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.01.001 · Cited by 461
The cell biology of the retinal pigment epithelium
Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100846 · Cited by 422
Agbaga, M., Brush, R. S., Mandal, M. N. A., Henry, K. R., Elliott, M. H., & Anderson, R. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802607105 · Cited by 276
Silver ion chromatography of lipids and fatty acids
Dobson, G., Christie, W. W., & Nikolova‐Damyanova, B. (1995) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(95)00157-e · Cited by 208
Metadata
- Authors
- Aveldaño, M. I.
- Corresponding author
- Aveldaño, M I
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1987-01
- Volume
- 262
- Issue
- 3
- Pages
- 1172-1179
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1567065116
- Cited by
- 142
- References
- 19
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 2 · 2012: 2
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- vertebrate retina, photoreceptor membranes, docosahexaenoic acid, omega-6 fatty acids, omega-3 fatty acids, fatty acid methyl esters, HPLC, gas-liquid chromatography, glycerophospholipids, fish retina, birds, mammals
- MeSH terms
- Animals, Cattle, Chromatography, Gas, Chromatography, High Pressure Liquid, Chromatography, Thin Layer, Fatty Acids, Unsaturated, Phosphatidylcholines, Photoreceptor Cells, Retina
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