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The Solubility of Amino Acids, Diglycine, and Triglycine in Aqueous Guanidine Hydrochloride Solutions
Open accessAbstract
Abstract The solubilities of amino acids, diglycine, and triglycine have been measured in water and 1 m to 6 m guanidine hydrochloride solutions. Free energies of transfer of amino acid side chains and backbone peptide units from water to guanidine hydrochloride solutions have been calculated from these data. The results show similarity between the patterns of solubilizing effects of guanidine hydrochloride and urea, although guanidine hydrochloride is 2 to 3 times more effective than urea at the same concentrations.
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Citations
Cited by
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 46,426
Wang, A., & Bolen, D. W. (1997) · Biochemistry · doi:10.1021/bi970247h · Cited by 451
Jeganathan, S., von Bergen, M., Mandelkow, E.-M., & Mandelkow, E. (2008) · Biochemistry · doi:10.1021/bi800783d · Cited by 286
Metadata
- Authors
- Nozaki, Y., & Tanford, C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1970-04
- Volume
- 245
- Issue
- 7
- Pages
- 1648-1652
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1935984619
- Cited by
- 351
- References
- 0
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: The Solubility of Amino Acids, Diglycine, and Triglycine in Aqueous Guanidine Hydrochloride Solutions. https://app.cochat.ai/papers/10.1016/s0021-9258(19)77141-5
- The paper
- Nozaki, Y., & Tanford, C. (1970). The Solubility of Amino Acids, Diglycine, and Triglycine in Aqueous Guanidine Hydrochloride Solutions. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)77141-5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
