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Beta-ketoacyl-acyl carrier protein synthase II of Escherichia coli. Evidence for function in the thermal regulation of fatty acid synthesis.
Open accessAbstract
Cvc- mutants of Escherichia coli are deficient in the synthesis of cis-vaccenic acid and in the temperature control of fatty acid synthesis. In this communication, it is demonstrated that these mutants lack beta-ketoacyl-acyl carrier protein synthase II. The deficiencies in cis-vaccenate synthesis and synthase II are shown to be due to a lesion in the same gene, fabF. Lesions in the fabF gene are found to affect growth only when the strain also carries a lesion in the fabB gene, the structural gene for beta-ketoacyl-acyl carrier protein synthase I.
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Citations
Cited by
Linkage map of Escherichia coli K-12, edition 7
Bachmann, B. (1983) · Microbiological Reviews · doi:10.1128/mmbr.47.2.180-230.1983 · Cited by 1,438
Membrane lipid homeostasis in bacteria
Zhang, Y.-M., & Rock, C. O. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1839 · Cited by 1,393
Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters
Cimermancic, P., Medema, M. H., Claesen, J., Kurita, K., Wieland Brown, L. C., Mavrommatis, K., Pati, A., Godfrey, P. A., Koehrsen, M., Clardy, J., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.034 · Cited by 981
Regulation of fatty acid biosynthesis in Escherichia coli
Magnuson, K. S., Jackowski, S., Rock, C. O., & Cronan, J. E. (1993) · Microbiological Reviews · doi:10.1128/mmbr.57.3.522-542.1993 · Cited by 654
Self-citationBacterial Fatty Acid Biosynthesis: Targets for Antibacterial Drug Discovery
Campbell, J. W., & Cronan, J. E. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.305 · Cited by 479
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Metadata
- Authors
- Garwin, J. L., Klages, A. L., & Cronan, J. E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1980-04
- Volume
- 255
- Issue
- 8
- Pages
- 3263-3265
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1510623452
- Cited by
- 195
- References
- 0
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Beta-ketoacyl-acyl carrier protein synthase II of Escherichia coli. Evidence for function in the thermal regulation of fatty acid synthesis. https://app.cochat.ai/papers/10.1016/s0021-9258(19)85692-2
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- Garwin, J. L., Klages, A. L., & Cronan, J. E. (1980). Beta-ketoacyl-acyl carrier protein synthase II of Escherichia coli. Evidence for function in the thermal regulation of fatty acid synthesis. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)85692-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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