Bacterial Fatty Acid Biosynthesis: Targets for Antibacterial Drug Discovery
Abstract
The increase in drug-resistant pathogenic bacteria has created an urgent demand for new antibiotics. Among the more attractive targets for the development of new antibacterial compounds are the enzymes of fatty acid biosynthesis. Although a number of potent inhibitors of microbial fatty acid biosynthesis have been discovered, few of these are clinically useful drugs. Several of these fatty acid biosynthesis inhibitors have potential as lead compounds in the development of new antibacterials. This review encompasses the known inhibitors and prospective targets for new antibacterials.
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The lipid profile of resting cells shows reorganisation after treatment with essential oil compounds.
“The lipid profile of resting cells shows reorganisation after treatment with EO compounds, and many authors have described the bacterial fatty acid synthesis pathway as an optimal target of many antibacterial agents [73,74,75].”
From Effect of essential oils on pathogenic bacteria (2013) · cites this paper as [73]
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Effect of essential oils on pathogenic bacteria
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Membrane toxicity of antimicrobial compounds from essential oils
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Host Fatty Acid Utilization by Staphylococcus aureus at the Infection Site
Frank, M. W., Yao, J., Batte, J. L., Gullett, J. M., Subramanian, C., Rosch, J. W., & Rock, C. O. (2020) · mBio · doi:10.1128/mbio.00920-20 · Cited by 57 · see citing works
- Authors
- Campbell, J. W., & Cronan, J. E.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- ORCID
- Cronan, John E.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2001-10
- Volume
- 55
- Issue
- 1
- Pages
- 305-332
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2131039226
- Cited by
- 479
- References
- 129
- Citations by year
- 2026: 14 · 2025: 12 · 2024: 15 · 2023: 15 · 2022: 15 · 2021: 12 · 2020: 21 · 2019: 11 · 2018: 18 · 2017: 21 · 2016: 26 · 2015: 25 · 2014: 27 · 2013: 18 · 2012: 25
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Keywords
- antibiotic discovery, antibiotic resistance, lead compounds, bacterial enzymes, antibiotic targets
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Enzyme Inhibitors, Fatty Acids, Molecular Structure, Drug Delivery Systems
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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