Cited by 479Lipid metabolism and biosynthesisCancer, Lipids, and MetabolismMicrobial Natural Products and Biosynthesis

Bacterial Fatty Acid Biosynthesis: Targets for Antibacterial Drug Discovery

Campbell, John W., Cronan, John E.·2001·Annual Review of Microbiology

Abstract

The increase in drug-resistant pathogenic bacteria has created an urgent demand for new antibiotics. Among the more attractive targets for the development of new antibacterial compounds are the enzymes of fatty acid biosynthesis. Although a number of potent inhibitors of microbial fatty acid biosynthesis have been discovered, few of these are clinically useful drugs. Several of these fatty acid biosynthesis inhibitors have potential as lead compounds in the development of new antibacterials. This review encompasses the known inhibitors and prospective targets for new antibacterials.

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Crossref · 10.1146/annurev.micro.55.1.305

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129 of 129 references verified0 citation errors · 0 not checkable

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  • The lipid profile of resting cells shows reorganisation after treatment with essential oil compounds.

    “The lipid profile of resting cells shows reorganisation after treatment with EO compounds, and many authors have described the bacterial fatty acid synthesis pathway as an optimal target of many antibacterial agents [73,74,75].”

    From Effect of essential oils on pathogenic bacteria (2013) · cites this paper as [73]

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Authors
Campbell, J. W., & Cronan, J. E.
Affiliations
University of Illinois Urbana-Champaign (US)
Venue
Annual Review of Microbiology
Published
2001-10
Volume
55
Issue
1
Pages
305-332
ISSN
  • 0066-4227 (ISSN-L)
  • 1545-3251
OpenAlex
W2131039226
Cited by
479
References
129
Citations by year
2026: 14 · 2025: 12 · 2024: 15 · 2023: 15 · 2022: 15 · 2021: 12 · 2020: 21 · 2019: 11 · 2018: 18 · 2017: 21 · 2016: 26 · 2015: 25 · 2014: 27 · 2013: 18 · 2012: 25
FWCI
1.41
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
Keywords
antibiotic discovery, antibiotic resistance, lead compounds, bacterial enzymes, antibiotic targets
MeSH terms
Anti-Bacterial Agents, Bacteria, Enzyme Inhibitors, Fatty Acids, Molecular Structure, Drug Delivery Systems

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