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Cited by 272

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Accumulation of glyceride-containing precursor of the outer membrane lipoprotein in the cytoplasmic membrane of Escherichia coli treated with globomycin.

Open access
Hussain, M., Ichihara, S., Mizushima, S.·1980·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(19)85762-9
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Abstract

The protein accumulated in the cell envelope of Escherichia coli treated with globomycin was identified as the precursor of the outer membrane lipoprotein. The prolipoprotein was almost exclusively localized in the cytoplasmic membrane. The prolipoprotein could be immunoprecipitated with antilipoprotein immunoglobulin and could be chased to the lipoprotein in both in vivo and in vitro. Globomycin inhibited the chase. The prolipoprotein contained glycerol and fatty acid residues, whereas no free sulfhydryl group was detected in it. From these results, it is concluded that the prolipoprotein possesses a glyceride which is covalently bound to the cysteine residue in the peptide as the lipoprotein does and that the removal of signal peptide takes place after the modification. The inhibition of bacterial growth with increasing concentrations of globomycin was accompanied by a gradual increase in the accumulation of the prolipoprotein. Furthermore, growth of the lipoprotein-negative mutant was highly resistant to globomycin. These results strongly indicate that the accumulation of the prolipoprotein in the cytoplasmic membrane causes the death of cells.

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Crossref · 10.1016/s0021-9258(19)85762-9

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Metadata

Authors
Hussain, M., Ichihara, S., & Mizushima, S.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1980-04
Volume
255
Issue
8
Pages
3707-3712
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(19)85762-9
OpenAlex
W1600437556
Cited by
272
References
27
FWCI
11.68
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Accumulation of glyceride-containing precursor of the outer membrane lipoprotein in the cytoplasmic membrane of Escherichia coli treated with globomycin. https://app.cochat.ai/papers/10.1016/s0021-9258(19)85762-9
The paper
Hussain, M., Ichihara, S., & Mizushima, S. (1980). Accumulation of glyceride-containing precursor of the outer membrane lipoprotein in the cytoplasmic membrane of Escherichia coli treated with globomycin. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)85762-9

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.