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Solubilization of the Cytoplasmic Membrane of Escherichia coli by the Ionic Detergent Sodium-Lauryl Sarcosinate
Open accessAbstract
The sensitivity of the outer and cytoplasmic membranes of Escherichia coli to detergent was examined by isopycnic sucrose density gradient centrifugation. Sodium lauryl sarcosinate (Sarkosyl) was found to disrupt the cytoplasmic membrane selectively under conditions in which Triton X-100 and dodecyl sodium sulfate solubilized all membrane protein. These results were verified by gel electrophoresis; membrane proteins solubilized by Sarkosyl were identical to those of the cytoplasmic membrane. The presence of Mg 2+ during treatment with Sarkosyl was found to afford partial protection of the cytoplasmic membrane from dissolution.
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Citations
Cited by
Hussain, M., Ichihara, S., & Mizushima, S. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85762-9 · Cited by 272
Drazek, E. S., Hammack, C. A., Sr, & Schmitt, M. P. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01818.x · Cited by 128
Metadata
- Authors
- Filip, C., Fletcher, G., Wulff, J. L., & Earhart, C. F.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1973-09
- Volume
- 115
- Issue
- 3
- Pages
- 717-722
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1943943023
- Cited by
- 953
- References
- 0
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Solubilization of the Cytoplasmic Membrane of Escherichia coli by the Ionic Detergent Sodium-Lauryl Sarcosinate. https://app.cochat.ai/papers/10.1128/jb.115.3.717-722.1973
- The paper
- Filip, C., Fletcher, G., Wulff, J. L., & Earhart, C. F. (1973). Solubilization of the Cytoplasmic Membrane of Escherichia coli by the Ionic Detergent Sodium-Lauryl Sarcosinate. Journal of Bacteriology. https://doi.org/10.1128/jb.115.3.717-722.1973
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
