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The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core.
Open accessAbstract
The three-dimensional structures of the snake venom postsynaptic neurotoxins and of the domains in wheat germ agglutinin show a remarkably similar overall folding pattern, consisting of equivalently placed, but variably sized loops which are held together by four similarly positioned disulfide bonds. Furthermore, occurrence of this wheat germ agglutinin-neurotoxin domain fold is predicted not only in the snake venom cardiotoxins and cytotoxins with neurotoxin-matched half-cystine sequence positions, but also for two small plant proteins, hevein and ragweed pollen allergen Ra5, on the basis of a nearly exact match of their half-cystine, sequence positions with those of the wheat germ agglutinin domain.
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Cited by
The Anatomy and Taxonomy of Protein Structure
Richardson, J. S. (1981) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60520-3 · Cited by 3,375
Self-citationFranco, B., Guioli, S., Pragliola, A., Incerti, B., Bardoni, B., Tonlorenzi, R., Carrozzo, R., Maestrini, E., Pieretti, M., Taillon-Miller, P., et al. (1991) · Nature · doi:10.1038/353529a0 · Cited by 846
Seminara, S. B., Hayes, F. J., & Crowley, W. F. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.5.0344 · Cited by 414
Kirchhoff, C., Habben, I., Ivell, R., & Krull, N. (1991) · Biology of Reproduction · doi:10.1095/biolreprod45.2.350 · Cited by 395
Metadata
- Authors
- Drenth, J., Low, B. W., Richardson, J. S., & Wright, C. S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1980-04
- Volume
- 255
- Issue
- 7
- Pages
- 2652-2655
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1569916771
- Cited by
- 158
- References
- 0
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core. https://app.cochat.ai/papers/10.1016/s0021-9258(19)85783-6
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- Drenth, J., Low, B. W., Richardson, J. S., & Wright, C. S. (1980). The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)85783-6
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