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Inositol 1,4,5-trisphosphate releases Ca2+ from a Ca2+-transporting membrane vesicle fraction derived from human platelets.

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O'Rourke, F A, Halenda, S P, Zavoico, G B, Feinstein, M B·1985·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(20)71193-2
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Abstract

Human platelet membrane vesicles that accumulated Ca2+ in the presence of ATP were isolated on an isoosmotic KCl-Percoll gradient. ATP-dependent Ca2+ uptake was stimulated by oxalate and phosphate to steady-state levels of greater than 100 nmol/mg protein, and the accumulated Ca2+ could be largely released by ionophore A23187. Inositol 1,4,5-trisphosphate, in a dose-dependent manner (0.5-5.0 microM), caused the rapid release (less than 5 s) of 40-70% of the total A23187-releasable store of accumulated Ca2+. The membrane vesicles that release accumulated Ca2+ in response to inositol 1,4,5-trisphosphate were enriched in enzymes characteristically found in smooth endoplasmic reticulum. These results support the hypothesis that inositol 1,4,5-trisphosphate, produced by the hydrolysis of phosphatidylinositol 1,4-bisphosphate in response to stimulation of cell surface receptors, is a second messenger mediating the release of Ca2+ from intracellular storage sites.

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Metadata

Authors
O'Rourke, F. A., Halenda, S. P., Zavoico, G. B., & Feinstein, M. B.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1985-01
Volume
260
Issue
2
Pages
956-962
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(20)71193-2
OpenAlex
W1583023128
Cited by
265
References
0
FWCI
25.33
Type
journal article
Language
en
Update notices
erratum (1985-06-25)
Open access
hybrid
Licence

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CoChat. (2026). Citation check: Inositol 1,4,5-trisphosphate releases Ca2+ from a Ca2+-transporting membrane vesicle fraction derived from human platelets. https://app.cochat.ai/papers/10.1016/s0021-9258(20)71193-2
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O'Rourke, F. A., Halenda, S. P., Zavoico, G. B., & Feinstein, M. B. (1985). Inositol 1,4,5-trisphosphate releases Ca2+ from a Ca2+-transporting membrane vesicle fraction derived from human platelets. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(20)71193-2

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