The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor.
Open accessAbstract
Experiments based on interaction in free solution between basic fibroblast growth factor (FGF-2) and saccharides related to heparin/heparan sulfate showed that the growth factor binds to heparin and to selectively glucosaminyl 6-O-desulfated heparin but poorly to iduronosyl 2-O-desulfated heparin. 2-O-sulfate groups thus are essential to the interaction, whereas 6-O-sulfates are not required nor do they interfere with FGF-2 binding. Comparison of various bound/nonbound oligosaccharides implicated a minimal pentasaccharide sequence for FGF-2 binding, with the structure: -hexuronic acid-glucosamine N-sulfate-hexuronic acid-glucosamine N-sulfate-iduronic acid 2-O-sulfate- (reducing terminus to the right). Such (overlapping) sequences are abundant in heparin, albeit heavily obscured by irrelevant O-sulfate groups, and occur also in heparan sulfate, with or without additional O-sulfates.
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Cites
Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., & Ornitz, D. M. (1991) · Cell · doi:10.1016/0092-8674(91)90512-w · Cited by 2,440
Cited by
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate
Esko, J. D., & Selleck, S. B. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135458 · Cited by 1,495
Heparin and heparan sulfate: Structure and function
Rabenstein, D. L. (2002) · Natural Product Reports · doi:10.1039/b100916h · Cited by 870
Regulated Diversity of Heparan Sulfate
Lindahl, U., Kusche-Gullberg, M., & Kjellén, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.24979 · Cited by 678
Self-citationTaylor, K. R., & Gallo, R. L. (2006) · The FASEB Journal · doi:10.1096/fj.05-4682rev · Cited by 639
Microbial adherence to and invasion through proteoglycans
Rostand, K. S., & Esko, J. D. (1997) · Infection and Immunity · doi:10.1128/iai.65.1.1-8.1997 · Cited by 490
Metadata
- Authors
- Maccarana, M., Casu, B., & Lindahl, U.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1993-11
- Volume
- 268
- Issue
- 32
- Pages
- 23898-23905
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1494551606
- Cited by
- 454
- References
- 1
- FWCI
- 12.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Maccarana, M., Casu, B., & Lindahl, U. (1993). Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(20)80470-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
