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Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated.
Open accessAbstract
The cardiac ventricular myosin phenotype is developmentally and hormonally regulated. The genes coding for the two myosin heavy chains ( MHCs ), alpha and beta, have been recently isolated and characterized. In this study, we establish the precise temporal expression of these MHC genes in correlation with the myosin phenotype both during cardiac development and in response to different thyroid hormone levels and also document their expression in other muscle tissues. The close correlation observed between the relative abundance of the alpha- and beta-MHC mRNAs and corresponding isozymes demonstrates that the MHC phenotype is produced by the expression of the alpha- and beta-MHC genes and is regulated by changes in the level of their respective mRNAs. The opposite effect of thyroid hormone on the expression of the alpha- and beta-MHC genes in the ventricular myocardium indicates that these genes are regulated in an antithetic fashion. Finally, the MHC mRNAs encoded by the alpha- and beta-MHC genes are also present in the atrial myocardium and in the soleus, respectively.
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Citations
Cited by
Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy
Marian, A. J., & Braunwald, E. (2017) · Circulation Research · doi:10.1161/circresaha.117.311059 · Cited by 1,403
A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance
van Rooij, E., Quiat, D., Johnson, B. A., Sutherland, L. B., Qi, X., Richardson, J. A., Kelm, R. J., & Olson, E. N. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.10.013 · Cited by 960
Watkins, H., Rosenzweig, A., Hwang, D.-S., Levi, T., McKenna, W., Seidman, C. E., & Seidman, J. G. (1992) · New England Journal of Medicine · doi:10.1056/nejm199204233261703 · Cited by 747
Izumo, S., Nadal-Ginard, B., & Mahdavi, V. (1986) · Science · doi:10.1126/science.3945800 · Cited by 621
Self-citationZhang, D., Shadrin, I. Y., Lam, J., Xian, H.-Q., Snodgrass, H. R., & Bursac, N. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.04.026 · Cited by 565
Metadata
- Authors
- Lompré, A. M., Nadal-Ginard, B., & Mahdavi, V
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1984-05
- Volume
- 259
- Issue
- 10
- Pages
- 6437-6446
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1609528353
- Cited by
- 610
- References
- 0
- FWCI
- 18.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated. https://app.cochat.ai/papers/10.1016/s0021-9258(20)82162-0
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- Lompré, A. M., Nadal-Ginard, B., & Mahdavi, V. (1984). Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(20)82162-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
