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Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides
Open accessAbstract
Remnants of triglyceride-rich lipoproteins (TRL) have been implicated in the early development of atherosclerosis. We tested this hypothesis by quantifying the plasma concentration of remnant-like particle cholesterol (RLP-C) in a cohort of healthy 50-year-old men in whom the common carotid artery intima-media thickness (CCA-IMT) was assessed by B-mode ultrasound as a surrogate marker for atherosclerosis. The subjects were given a fat-rich meal to study the generation of RLP-C during postprandial lipemia. Fasting plasma RLP-C and other major fasting plasma lipids and lipoproteins were determined twice, and the mean RLP-C concentration was strongly correlated with CCA-IMT (r = 0.32, P = 0.002). In addition, low density lipoprotein (LDL) cholesterol (r = 0.25, P = 0.01) and plasma triglycerides (r = 0.20, P = 0.05) were significantly related to CCA-IMT. Multivariate analyses showed a triglyceride-independent contribution of RLP-C to CCA-IMT. After fat intake, the median plasma RLP-C concentration was doubled after 3 h. The increase was strongly related to the postprandial generation of TRL apolipoprotein (apo)B-48, and large (S(f) 60;-400) TRL apoB-100. The association with CCA-IMT was somewhat stronger for the 3-h RLP-C level than for the fasting RLP-C concentration [r = 0.27, P < 0.01 (3 h) compared with r = 0.22, P < 0.05 (0 h)]. We conclude that the plasma concentration of RLP-C is related to CCA-IMT, independent of plasma triglycerides and LDL cholesterol, in a healthy middle-aged male population. - Karpe, F., S. Boquist, R. Tang, G. M. Bond, U. de Faire, and A. Hamsten. Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides. J. Lipid Res. 2001. 42: 17;-21.
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“As a result, elevated levels of cholesterol-enriched remnant lipoproteins contribute to the development of premature coronary [22,23,24] and peripheral [25,26] atherosclerosis.”
From Spectrum and Prevalence of Rare APOE Variants and Their Association with Familial Dysbetalipoproteinemia (2024) · cites this paper as [25]
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Cites
Carlson, K. (1973) · Journal of Clinical Pathology · doi:10.1136/jcp.s1-5.1.32 · Cited by 420
Nakajima, K., SAITO, T., Tamura, A., Suzuki, M., Nakano, T., Adachi, M., Tanaka, A., Tada, N., Nakamura, H., Campos, E. M., et al. (1993) · Clinica Chimica Acta · doi:10.1016/0009-8981(93)90062-9 · Cited by 417
Phillips, A. N., & Smith, G. D. (1991) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(91)90155-3 · Cited by 275
Boquist, S., Ruotolo, G., Tang, R., Björkegren, J., Bond, M. G., Fairé, U. D., Karpe, F., & Hamsten, A. (1999) · Circulation · doi:10.1161/01.cir.100.7.723 · Cited by 258
Self-citationCampos, E. M., Nakajima, K., Tanaka, A., & Havel, R. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41527-5 · Cited by 185
Karpe, F., & Hamsten, A. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39974-0 · Cited by 182
Self-citationKarpe, F., Fairé, U. D., Mercuri, M. F., BOND, M., Hellénius, M.-L., & Hamsten, A. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00184-1 · Cited by 110
Self-citationKarpe, F., Hellénius, M.-L., & Hamsten, A. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90076-8 · Cited by 97
Self-citationTriglycerides are more important in atherosclerosis than epidemiology has suggested
Durrington, P. N. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00219-6 · Cited by 72
Björkegren, J., Boquist, S., Samnegård, A., Lundman, P., Tornvall, P., Ericsson, C.-G., & Hamsten, A. (2000) · Circulation · doi:10.1161/01.cir.101.3.227 · Cited by 70
Self-citationAlterations of VLDL composition during alimentary lipemia
Björkegren, J., Hamsten, A., Milne, R. W., & Karpe, F. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37443-5 · Cited by 66
Self-citationMarcoux, C., Tremblay, M., Nakajima, K., Davignon, J., & Cohn, J. S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32142-8 · Cited by 61
Marcoux, C., Tremblay, M., Fredenrich, A., Jacques, H., Krimbou, L., Nakajima, K., Davignon, J., & Cohn, J. S. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00042-2 · Cited by 45
Mercuri, M. F., Tang, R., Phillips, R. M., & Bond, M. G. (1996) · PubMed · Cited by 23
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Research works printed but not linked: 1
- Nakajima, 1996, Separation and determination of remnant-like particles in human serum using monoclonal antibodies to apo B and apo A-I, J. Clin. Ligand Assay, 19, 177
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Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease
Varbo, A., Benn, M., Tybjærg-Hansen, A., Jørgensen, A. B., Frikke-Schmidt, R., & Nordestgaard, B. G. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.08.1026 · Cited by 1,115
Lipid and lipoprotein dysregulation in insulin resistant states
Avramoglu, R. K., Basciano, H., & Adeli, K. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.12.026 · Cited by 326
Haidari, M., Leung, N., Mahbub, F., Uffelman, K., Kohen-Avramoglu, R., Lewis, G., & Adeli, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200544200 · Cited by 191
Varbo, A., Benn, M., & Nordestgaard, B. G. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.11.008 · Cited by 251
Nakajima, K., Nakano, T., & Tanaka, A. (2006) · Clinica chimica acta; international journal of clinical chemistry · doi:10.1016/j.cca.2005.12.013 · Cited by 205
Metadata
- Authors
- Karpe, F., Boquist, S., Tang, R., Bond, G. M., de Faire, U., & Hamsten, A.
- Affiliations
- Karolinska Institutet (SE)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Karpe, Fredrik
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 42
- Issue
- 1
- Pages
- 17-21
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W1936800019
- Cited by
- 174
- References
- 14
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 6
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- remnant-like particle cholesterol, remnant lipoproteins, triglyceride-rich lipoproteins, carotid intima-media thickness, atherosclerosis, LDL cholesterol, plasma triglycerides, postprandial lipemia, apolipoprotein B-48, apolipoprotein B-100, high-fat meal, middle-aged men
- MeSH terms
- Apolipoproteins, Arteriosclerosis, Carotid Arteries, Cholesterol, Fasting, Humans, Lipoproteins, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Ultrasonography, Cohort Studies, Linear Models, Tunica Intima
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